Knockdown of in Pancreatic Cancer Helps Ameliorate Gemcitabine Resistance.

Background: The gene is a gemcitabine (GEM) resistance gene; however, the mechanism by which it regulates GEM resistance in pancreatic cancer remains unclear.

Methods: The cell line was treated with GEM and then stimulated with . Subsequently, we constructed GEM-resistant pancreatic cancer cell lines, knocked down in these cell lines, and detected changes in the proliferation and apoptosis of drug-resistant cancer cells.

Sphincter of Oddi Dysfunction Induces Gallstone by Inhibiting the Expression of ABCB11 via PKC-α.

The abnormal increase of Oddi sphincter pressure and total bile duct pressure may play an important role in the formation of cholesterol stones, but the specific molecular mechanism is still unclear. This study aims to investigate it through in vitro and in vivo experiments. A mouse model of Oddi sphincter dysfunction was constructed by stone-inducing diet.

The KLF4-p62 axis prevents vascular endothelial cell injury via the mTOR/S6K pathway and autophagy in diabetic kidney disease.

Introduction: Diabetic kidney disease (DKD) is a complication of systemic diabetic microangiopathy, which has a high risk of developing into end-stage renal disease and death. This study explored the mechanism underlying autophagy in DKD vascular endothelial cell injury.

Material And Methods: DKD and vascular endothelial cell injury models were established using Sprague Dawley rats and human umbilical vein endothelial cells (HUVECs).

Hot electron prompted highly efficient photocatalysis based on 3D graphene/non-precious metal nanoparticles.

High dispersibility and rapid electron transfer are required for a highly efficient catalyst. In this work, such materials have been designed using a scalable hydrothermal method from graphene oxide and a metal-organic framework. A cross-linked three-dimensional graphene (3DGraphene) material loaded with mono-dispersed nitrogen-doped carbon-coated metallic Co (NC@Co) nanoparticles with uniform size of 12.

Controlling and optimizing the morphology and microstructure of 3D interconnected activated carbons for high performance supercapacitors.

For an active electrode material, the morphology, microstructure and the effective specific surface area derived from them, have a dominant effect for the high performance supercapacitors. In this study, 3D interconnected activated carbons with controlled and optimized morphologies and porous structures were prepared from accessible carbon source and graphene oxide by a hydrothermal carbonization and following an activation method. Through optimizing the ratios of the precursors and reaction conditions, an electrode material with excellent specific surface area of 2318 m g, meso-/macro-pore ratio of 63.

Multiple metallic foreign bodies accidentally detected in different body cavities: a case report.

We accidentally found an unusual case of a middle aged Tibetan woman who had eight metallic foreign bodies (eight needles) in her head, chest and abdomen. These needles were not related to any surgical intervention or trauma. The diagnosis "metallic foreign bodies" cannot usually be made in an acute setting.

μ-4,4'-Bipyridine-κ2N:N'-bis[tetraaqua(4,4'-bipyridine-κN)dimanganese(II)] bis(4-aminobenzoate) bis(perchlorate)-4,4'-bipyridine-water (1/2/4): a supramolecular system constructed by π-π and hydrogen-bond interactions.

The title dinuclear manganese compound, [Mn(2)(C(10)H(8)N(2))(3)(H(2)O)(8)](C(7)H(6)NO(2))(2)(ClO(4))(2)·2C(10)H(8)N(2)·4H(2)O, (I), has an inversion center located midway between the Mn(II) ions. Each Mn(II) ion has a distorted octahedral coordination environment, defined by two mutually cis N atoms from two different 4,4'-bipyridine (4,4'-bipy) ligands and four O atoms from four water molecules. The asymmetric unit contains cationic [Mn(4,4'-bipy)(1.

μ-4,4'-Bipyridine-κ2N:N'-bis[triaqua(4,4'-bipyridine-κN)cadmium(II)] bis(3-aminobenzoate) bis(perchlorate) dihydrate: a novel supramolecular system constructed by π-π and hydrogen-bonding interactions.

The title dicadmium compound, [Cd(2)(C(10)H(8)N(2))(5)(H(2)O)(6)](C(7)H(6)NO(2))(2)(ClO(4))(2)·2H(2)O, is located around an inversion centre. Each Cd(II) centre is coordinated by three N atoms from three different 4,4'-bipyridine ligands and three O atoms from three coordinating water molecules in a distorted octahedral coordination environment. In the dicadmium cation unit, one 4,4'-bipyridine (4,4'-bipy) molecule acts as a bidentate bridging ligand between two Cd metal ions, while the other four 4,4'-bipy molecules act only as monodentate terminal ligands, resulting in a rare `H-type' [Cd(2)(C(10)H(8)N(2))(5)(H(2)O)(6)] host unit.

catena-Poly[tris-(μ(2)-1H-benzimidazole-5-carboxyl-ato)europium(III)].

In the title one-dimensional coordination polymer, [Eu(C(8)H(5)N(2)O(2))(3)](n), the Eu(III) ion is eight-coordinated by the carboxyl-ate O atoms of six ligands in a distorted monocapped penta-gonal-bipyramidal geometry. The ligands link Eu(III) ions, forming helical chains parallel to the c axis, with Eu⋯Eu separations of 4.0678 (11) Å.