Publications by authors named "Junliang Wan"
Article Synopsis
- Hibernation helps animals conserve energy by lowering their metabolic rate and aids survival in tough conditions, but the details of energy adaptation in hibernating ectotherms are still debated.
- The study found decreased lipid levels and metabolism-related gene expression during hibernation, leading to reduced fat cell sizes and lipid content in the liver, along with lower serum lipid levels and increased glucose.
- Transcriptomic and lipidomic analyses showed a suppression of lipid metabolism pathways and genes tied to fat breakdown (lipolysis) during hibernation, enhancing our understanding of how these animals adapt their energy use for survival.
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that lack a 1-hydroxyl group as a result of the utilization of l-alanine or glycine instead of l-serine, resulting in the formation of 1-deoxy- or 1-desoxymethylsphingoid bases, respectively. Elevated production of "atypical" sphingolipids has been associated with human disease, but 1-deoxysphingoid bases have also been found to have potential as anticancer compounds, hence, the importance of knowing more about the occurrence of these compounds in food.
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