DDAM-Net: A Difference-Directed Multi-Scale Attention Mechanism Network for Cultivated Land Change Detection.

Declining cultivated land poses a serious threat to food security. However, existing Change Detection (CD) methods are insufficient for overcoming intra-class differences in cropland, and the accumulation of irrelevant features and loss of key features leads to poor detection results. To effectively identify changes in agricultural land, we propose a Difference-Directed Multi-scale Attention Mechanism Network (DDAM-Net).

Early short-term hypoxia promotes epidermal cell migration by activating the CCL2-ERK1/2 pathway and epithelial-mesenchymal transition during wound healing.

Background: Due to vasculature injury and increased oxygen consumption, the early wound microenvironment is typically in a hypoxic state. We observed enhanced cell migration ability under early short-term hypoxia. CCL2 belongs to the CC chemokine family and was found to be increased in early hypoxic wounds and enriched in the extracellular signal-regulated kinase (ERK)1/2 pathway in our previous study.

Engineering an Almost All-Waterborne System for Transparent yet Superhydrophobic Surfaces with High Liquid Impalement Resistance.

Realistically, green manufacturing of transparent superhydrophobic surfaces (SHSs) and high liquid impalement resistance for outdoor engineering are very necessary but pretty challenging. To address this, an almost all-waterborne system composed of synthesized partially open-cage fluorinated polyhedral oligomeric silsesquioxane bearing a pair of -OH (poc-FPOSS-2OH), silica sol, and resin precursor is engineered. The transparent SHSs facilely formed by this system are featured with the exclusive presence of wrapped silica nanoparticle (SiNP) dendritic networks at solid-gas interfaces.

[Screening of pathogenic molecular markers of in children based on whole genome sequencing technology].

Objectives: To explore the molecular characteristics of () in children, and to compare the molecular characteristics of different types of strains (infection and colonization strains) so as to reveal pathogenic molecular markers of .

Methods: A cross-sectional study design was used to conduct nasopharyngeal swab sampling from healthy children in the community and clinical samples from infected children in the hospital. Whole genome sequencing was used to detect antibiotic resistance genes and virulence genes.

DNMT3A-mediated epigenetic silencing of SOX17 contributes to endothelial cell migration and fibroblast activation in wound healing.

Background: Wound healing, especially impaired chronic wound healing, poses a tremendous challenge for modern medicine. Understanding the molecular mechanisms underlying wound healing is essential to the development of novel therapeutic strategies.

Methods: A wound-healing mouse model was established to analyze histopathological alterations during wound healing, and the expression of SRY-box transcription factor 17 (SOX17), DNA methyltransferase 3 alpha (DNMT3A), and a specific fibroblast marker S100 calcium-binding protein A4 (S100A4) in wound skin tissues was tested by immunofluorescence (IF) assay.

Regeneration of Activated Sludge into SiO-Decorated Heteroatom-Doped Porous Carbon as Advanced Electrodes for Li-S Batteries.

The regeneration of harmful activated sludge into an energy source is an important strategy for municipal sludge treatment and recycling. Herein, SiO-modified N,S auto-doped porous carbon (NSC@SiO) with high conductivity (70 S m) is successfully obtained through a simple calcination method of the activated sludge from wastewater treatment. Further, P-doped NSC@SiO (NSPC@SiO) is designed to achieve a higher surface area (891 m g vs 624 m g), a larger pore volume (0.

Nasopharyngeal aspirates in children with severe community-acquired pneumonia collected within 3 days before bronchoscopy can partially reflect the pathogens in bronchoalveolar lavage fluids.

Background: There is little evidence about consistency between nasopharyngeal and pulmonary pathogens in children with severe pneumonia. This study aims to compare the difference of pathogens between nasopharyngeal aspirates (NPAs) collected before bronchoscopy and bronchoalveolar lavage fluids (BALFs) in children with severe community-acquired pneumonia (SCAP).

Methods: NPAs and BALFs were collected form pediatric SCAP cases hospitalized from January 2018 to March 2019.

Autophagy promotes directed migration of HUVEC in response to electric fields through the ROS/SIRT1/FOXO1 pathway.

Endogenous electric fields (EFs) have been confirmed to facilitate angiogenesis through guiding directional migration of endothelial cells (ECs), but the underlying mechanisms remain obscure. Recent studies suggest that the directed migration of ECs in angiogenesis is correlated with autophagy, and the latter of which could be augmented by EFs. We hypothesize that autophagy may participate in the EFs-guided migration of ECs during angiogenesis.

Co-carriage of and among preschool children and its influencing factors.

Objectives: To investigate the carriage status of () and () in preschool children and the influencing factors for the carriage status.

Methods: The stratified cluster sampling method was used to select 2 031 healthy children from seven kindergartens in Shunde District of Foshan in Guangdong, China. Nasal swabs were collected from all children for the isolation and identification of and .

Multivariate Strategy Preparation of Nanoscale Ru-Doped Metal-Organic Frameworks with Boosted Photoactivity for Bioimaging and Reactive Oxygen Species Generation.

How to incorporate chromophores into MOFs is a key for the development of multifunctional photoactive systems. The poor internalization by cancer cells and low efficiency of ROS generation hamper the potential clinic application of Ru-based molecular agents. In this work, a nanoscale Ru-doped metal-organic framework Hf-UiO-Ru (Hf-Ru) with framework-boosted photoactivities was prepared a multivariate strategy for use in bioimaging and ROS generation.

Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy.

Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice.

Efficacy of Low-Dose rhGM-CSF Treatment in a Patient With Severe Congenital Neutropenia Due to CSF3R Deficiency: Case Report of a Novel Biallelic CSF3R Mutation and Literature Review.

This study reports the clinical manifestations, genetics, and efficacy of treatment with the efficacy of recombinant human granulocyte macrophage colony-stimulating factor (rhGM-GSF) of a 2-year-old female patient with severe congenital neutropenia (SCN) type 7 (SCN7) caused by novel biallelic mutations in the colony-stimulating factor 3 receptor () gene. Genetic diagnosis of the patient was performed by whole-exome and Sanger sequencing. Expression of the gene in the peripheral neutrophils of the patient was detected by real-time PCR and Western blotting.

Clinical and molecular characteristics of Wiskott-Aldrich Syndrome in five unrelated Chinese families.

Wiskott-Aldrich syndrome (WAS) also called the eczema-thrombocytopenia-immunodeficiency syndrome is a primary immunodeficiency disease with X-linked recessive inheritance caused by mutations in the WAS protein (WASp) gene and characterized by thrombocytopenia with reduced platelet volume, eczema, immunodeficiency, and increased risk of malignant tumours. The mutations will lead to separate WAS severity which can be typical severe 'classical' WAS or less severe 'non-classical' WAS. This article will review and analyse clinical and immune characteristics of five unrelated Chinese families harbouring classical and non-classical WAS.

Structural diversity of nanoscale zirconium porphyrin MOFs and their photoactivities and biological performances.

Photoactive MOF-based delivery systems are highly attractive for photodynamic therapy (PDT), but the fundamental interplay among structural parameters and photoactivity and biological properties of these MOFs remains unclear. Herein, porphyrinic MOF isomers (TCPP-MOFs), constructing using the same building blocks into distinct topologies, have been selected as ideal models to understand this problem. Both the intramolecular distances and molecular polarization within TCPP-MOFs isomers collectively contribute to the photoactivity of generating reactive oxygen species.

Defect Engineering of Nanoscale Hf-Based Metal-Organic Frameworks for Highly Efficient Iodine Capture.

With the rapid development of the nuclear industry, how to deal with radioactive iodine waste in a timely and effective manner has become an important issue to be solved urgently. Herein, the defect-engineering strategy has been applied to develop a metal-organic framework (MOF)-based solid adsorbent by using the classical UiO-type Hf-UiO-66 as an example. After simple acid treatment, the produced defect-containing Hf-UiO-66 (DHUN) not only retains its topological structure, high crystallization, and regular shape but also shows a great increase in the Brunauer-Emmett-Teller value and pore size in comparison with the original Hf-UiO (HUN).

Merocyanine-paclitaxel conjugates for photothermal induced chemotherapy.

Small molecular nanomedicines that integrate the flexibility of self-assembly strategies and the advantages of a precise molecular structure, a high drug content and controlled drug release are effective diagnostic and therapeutic modalities. Herein, merocyanine-paclitaxel conjugates (MC-PTX) were developed and fabricated by using the degradable ester bonds as the linker. The as-prepared MC-PTX could self-assemble into nanoparticles (MC-PTX NPs) using the non-covalent molecular interaction via the nanoprecipitation method.

Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes.

This study aimed to explore the effects and possible mechanisms of intravenous lidocaine in postherpetic neuralgia (PHN) rats. Mechanical withdrawal thresholds and thermal withdrawal latencies were measured. Open field test, elevated plus maze test, and tail suspension test were used to assess anxiety- and depressive-like behaviors.

Interconnected NiCoO nanosheet arrays grown on carbon cloth as a host, adsorber and catalyst for sulfur species enabling high-performance Li-S batteries.

Li-S batteries are a promising next-generation electrochemical energy-storage system due to their high energy density, as well as the abundance and low cost of sulfur. However, the low conductivity of sulfur and LiS/LiS, as well as the dissolution and shuttling of intermediate lithium polysulfides, is a great challenge for high-performance Li-S batteries. Herein, interconnected NiCoO nanosheet arrays grown on carbon cloth (CC) are applied as the cathode (S/NiCoO/CC) in Li-S batteries for accommodating sulfur.

Insights into the epidemiology of methicillin-resistant coagulase-negative Staphylococci carriage in community-based drug users.

Background: Coagulase-negative Staphylococci (CoNS) are opportunistic pathogens. Methicillin-resistant CoNS (MRCoNS) remain a major cause of nosocomial infections, but limited information is available in communities. We, therefore, aimed to investigate the epidemiology of CoNS nasal carriage, especially MRCoNS in community-based drug users.

Zoster sine herpete: a review.

Zoster sine herpete (ZSH) is one of the atypical clinical manifestations of herpes zoster (HZ), which stems from infection and reactivation of the varicella-zoster virus (VZV) in the cranial nerve, spinal nerve, viscera, or autonomic nerve. Patients with ZSH display variable symptoms, such as neuralgia, however, different from HZ, ZSH show no zoster, which makes clinical diagnosis difficult. ZSH not only causes initial symptoms, such as neuropathic pain in the affected nerve, Bell palsy, and Ramsay Hunt syndrome, but also postherpetic neuralgia and fatal complications such as VZV encephalitis and stroke.

Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy.

The developing nanoparticle therapeutic agents triggered by tumor microenvironment are a feasible strategy for the substantial elevation of accuracy of diagnosis and the reduction of side effects in cancer treatments. Dysregulated HS production from the enzyme system of overexpressed cystathionine β-synthase has long been considered to act as an autocrine and paracrine factor for the tumor growth and proliferation of colon cancer. Herein, for the first time, an endogenous HS-activated copper metal-organic framework (Cu-MOF; HKUST-1) nanoenzyme has been demonstrated to synergistically mediate HS-activated near-infrared photothermal therapy and chemodynamic therapy in the effective treatment of colon cancer.