Basic Science and Pathogenesis.

Background: Alzheimer's disease (AD) is pathologically defined by the presence of extracellular Aβ plaque and intracellular tau inclusions. Emerging evidence shows that tau aggregates contain pathogenic bioactivities of templating monomeric tau into filamentous fibrils and propagating through cells. Based on these findings, assays have been developed to detect minute amounts of pathogenic tau in human samples.

Nested hollow-core anti-resonant fiber with elliptical cladding for 2 µm laser transmission.

In this work, a nested hollow-core anti-resonant fiber (HC-ARF) with an elliptical cladding for high-power lasers for 2 µm laser transmission was proposed and theoretically investigated. The dual-layer elliptical tubes nested within the fiber enable the low-loss single-mode transmission. The finite element method (FEM) was employed to analyze and optimize the structure of fiber, with a total loss of less than 5 × 10dB/m across the wavelength range of 1920nm to 2040nm.

Mental Fatigue in Parkinson's Disease: Systematic Review and Evaluation of Self-Reported Fatigue Scales.

Fatigue is a common and debilitating symptom affecting a significant proportion of individuals with Parkinson's disease (PD), often overshadowing even motor symptoms in its impact on quality of life. The accurate definition and assessment of mental fatigue in PD is crucial for both clinical management and research, yet it remains a challenge due to the subjective nature of the symptom and the heterogeneity of assessment scales. This systematic review examined the existing measures of self-reported mental fatigue in PD by searching through PubMed, Embase, and Scopus databases using specific keywords from 2001 to 2024.