Publications by authors named "Junko Yoshida Garcon"
Article Synopsis
- Scientists studied how sleep is regulated in male mice, especially after staying awake for a long time.
- They found that a special protein called CaMKII helps control certain brain cells (called PV neurons) that are important for sleep.
- When these PV neurons become more active, it leads to more rebound sleep, which happens after being awake for too long.
The reduced sleep duration previously observed in Camk2b knockout mice revealed a role for Ca2+/calmodulin-dependent protein kinase II (CaMKII)β as a sleep-promoting kinase. However, the underlying mechanism by which CaMKIIβ supports sleep regulation is largely unknown. Here, we demonstrate that activation or inhibition of CaMKIIβ can increase or decrease sleep duration in mice by almost 2-fold, supporting the role of CaMKIIβ as a core sleep regulator in mammals.
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