Publications by authors named "Junko Wakao"
Article Synopsis
- * Researchers prepared dMBs by modifying human fibroblasts and implanted silicon tubes under the skin of mice to create biosheets, which were then seeded with dMBs and a nanogel or Matrigel.
- * Results showed that the combination of dMBs with the nanogel led to better muscle cell development and expression, indicating potential for using these tissues for regenerative medicine.
The skeletal muscle consists of contractile myofibers and plays essential roles for maintenance of body posture, movement, and metabolic regulation. During the development and regeneration of the skeletal muscle tissue, the myoblasts fuse into multinucleated myotubes that subsequently form myofibers. Transplantation of myoblasts may make possible a novel regenerative therapy against defects or dysfunction of the skeletal muscle.
View Article and Find Full Text PDFBackground: A recent study reported that relapsed neuroblastomas had frequent RAS-ERK pathway mutations. We herein investigated the effects and pathways of MEK inhibitors, which inhibit the RAS-ERK pathway, as a new molecular-targeted therapy for refractory neuroblastomas.
Method: Five neuroblastoma cell lines were treated with trametinib (MEK inhibitor) or CH5126766 (RAF/MEK inhibitor).
Background: Human mesenchymal stem cells (hMSCs) are multipotent stem-like cells that are reported to have tumor-suppression effects and migration ability toward damaged tissues or tumors. The aim of this study was to analyze the tumor-homing ability of hMSCs and antitumor potency in a transgenic TH-MYCN mouse model of neuroblastoma (NB).
Methods: hMSCs (3×10) labeled with DiR, a lipophilic near-infrared dye, were intraperitoneally (i.
Article Synopsis
- - The study investigates the effectiveness of the neuropeptide bombesin (BBS) in improving lung development in a rat model of congenital diaphragmatic hernia (CDH), a condition that can lead to underdeveloped lungs due to fetal complications.
- - Pregnant rats were treated with nitrofen to induce CDH and then received daily BBS injections; findings showed that BBS treatment significantly improved the lung-to-body weight ratio and cell proliferation compared to untreated rats.
- - Results indicate that BBS may help rescue lung hypoplasia associated with fetal CDH, highlighting its potential role in promoting lung maturity and development.