Publications by authors named "Junki Mori"
Increased expression of thioredoxin-interacting protein (TXNIP) has recently been proved to be a crucial event for irremediable endoplasmic reticulum (ER) stress resulting in the programmed cell death (apoptosis) of pancreatic β-cells. The present study demonstrated that treatment with 1-10 μg/ml tunicamycin, a potent revulsant of ER stress, drastically induced TXNIP expression accompanied by the generation of cleaved caspase-3 as an indicator of apoptosis in SK-N-SH human neuroblastoma cells. This result substantiated that TXNIP is also involved in neurodegeneration triggered by ER stress.
View Article and Find Full Text PDFCharacteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
Biochem Biophys Res Commun
February 2013
Article Synopsis
- Nobiletin, a flavonoid found in citrus peels, shows potential benefits against cancer, hyperlipidemia, hyperglycemia, and dementia.
- In a study, it was found to significantly alter gene expression in rat fibroblasts and human cancer cells, increasing certain stress-response genes and decreasing cell cycle and oxidative stress-related genes.
- The results suggest that nobiletin may produce its diverse effects by inducing endoplasmic reticulum stress and reducing oxidative stress and cell proliferation.