Publications by authors named "Junki Jinno"
Acta Neuropathol
November 2020
Article Synopsis
- Mislocalization of the TDP-43 protein in neurons is a key feature in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but its role in disease mechanisms is not well understood.
- Researchers hypothesized that TDP-43's failure to transport mRNA to axons could contribute to neurodegeneration and found that TDP-43 binds to and helps transport ribosomal protein (RP) mRNAs necessary for local protein synthesis in axons.
- Their study demonstrated that reduced levels of RP mRNAs in ALS cases with TDP-43 pathology could impair the function of axonal ribosomes, revealing a crucial role for TDP-43 in maintaining axonal health and its relation to neuro
