Publications by authors named "Junjie Tony Hua"
Prostate cancer is the second most commonly diagnosed malignancy among men worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes a pioneer transcription factor involved in disease onset and progression through both androgen receptor-dependent and androgen receptor-independent mechanisms. Despite its oncogenic properties however, the regulation of FOXA1 expression remains unknown.
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- The study analyzed the complex transcriptome of localized prostate cancer using ultra-deep RNA sequencing on 144 tumors, uncovering a subtype linked to aggressive cancer behavior and distinct fusion patterns differentiating localized from metastatic disease.* -
- Researchers discovered a significant prevalence of circular RNAs (circRNAs) in tumors, with an average of 7,232 circRNAs per tumor, and found that circRNA production levels correlated with disease progression across various patient groups.* -
- Functional screening revealed that about 11% of the highly expressed circRNAs were crucial for cancer cell proliferation, with some circRNAs, like circCSNK1G3, specifically promoting cell growth through interactions with microRNAs.*
Neuroendocrine prostate cancer (NEPC), a lethal form of the disease, is characterized by loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which results in resistance to AR-targeted therapy. Clinically, genomically and epigenetically, NEPC resembles other types of poorly differentiated neuroendocrine tumors (NETs). Through pan-NET analyses, we identified ONECUT2 as a candidate master transcriptional regulator of poorly differentiated NETs.
View Article and Find Full Text PDFN6-Methyladenosine (m6A) accounts for approximately 0.2% to 0.6% of all adenosine in mammalian mRNA, representing the most abundant internal mRNA modifications.
View Article and Find Full Text PDFThe prostate cancer (PCa) risk-associated SNP rs11672691 is positively associated with aggressive disease at diagnosis. We showed that rs11672691 maps to the promoter of a short isoform of long noncoding RNA PCAT19 (PCAT19-short), which is in the third intron of the long isoform (PCAT19-long). The risk variant is associated with decreased and increased levels of PCAT19-short and PCAT19-long, respectively.
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