Publications by authors named "Junjie Qiu"

Background: Hawthorn fruit, renowned as both a functional food and herbal medicine with lipid-lowering effects, is abundant in polysaccharides. However, there is limited research on the effects and mechanisms of hawthorn fruit polysaccharides (HP) in addressing non-alcoholic fatty liver disease (NAFLD).

Purpose: This study aims to investigate the effects of HP on NAFLD both in vivo and in vitro, and to elucidate the underlying mechanisms by which HP exerts its anti-NAFLD activity.

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α-Terpineol and 1,8-cineole are two important compounds in essential oils. This study developed an efficient method to recover α-terpineol from model oil (MO) based on association extraction by in situ formations of deep eutectic solvent (DES) between α-terpineol and some quaternary ammonium salts (QASs) by hydrogen-bond (HB) interaction. Such interaction could be broken almost completely by the introduction of water, due to the stronger HB interaction between water and QASs, which could release α-terpineol by liquid-liquid separation and save the organic solvents consumption.

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Article Synopsis
  • The study investigates the effectiveness of expansive open-door laminoplasty (ELAP) for treating multilevel cervical spondylotic myelopathy (CSM) in Chinese patients, focusing on short-term prognostic factors.
  • The research involved 98 patients who underwent ELAP, measuring outcomes like pain and functional improvement one year post-surgery through various clinical scales and imaging analyses.
  • Results showed significant improvements in both clinical scores and imaging indicators after surgery, along with age, duration of disease, and pre-operative scores identified as key factors influencing recovery.
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Exploring the transfer ability of proton carriers at different relative humidity (RH) is vital for the rational design and development of high-performance proton exchange membranes (PEMs). However, the highly humidity-dependent transfer channel and random carrier distribution disqualify most membrane materials. Herein, a series of MIL-53 metal-organic framework (MOF) nanosheets with stable, quantifiable pore structures and different conducting groups are prepared through postsynthetic ligand exchange, followed by spin coating to assemble lamellar membranes.

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  • Researchers improved lipid nanoparticles (LNPs) for targeted mRNA delivery to specific organs, like the lungs and liver.
  • They created a library of new cationic lipids and optimized LNP compositions, finding that cholesterol and phospholipids are not essential for effectiveness.
  • This strategy enhances mRNA accumulation and translation in the target organs, potentially advancing mRNA therapy for various diseases.
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A regular tetrahedron model was established to pierce the fractionation of dissolved organic matter (DOM) among quaternary components by using high-resolution mass spectrometry. The model can stereoscopically visualize molecular formulas of DOM to show the preference to each component according to the position in a regular tetrahedron. A classification method was subsequently developed to divide molecular formulas into 15 categories related to fractionation ratios, the relative change of which was demonstrated to be convergent with the uncertainty of mass peak area.

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To address the inherent limitations of conventional carbon nanotubes (CNTs), such as their tendency to agglomerate and scarcity of catalytic sites, the development of branched carbon nanotubes (BCNTs) with a unique hierarchical structure has emerged as a promising solution. Herein, gram scale quantities of densely branched and structurally consistent Ni-Fe decorated branched CNTs (Ni-Fe@BCNT) have been prepared. This uniform and densely branched architecture ensures excellent dispersibility and superior electrical conductivity.

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Ethnopharmacological Relevance: Shaoyao Gancao Fuzi Decoction (SGFD), has been employed for thousands of years in the treatment of rheumatoid arthritis (RA) with remarkable clinical efficacy. However, the material basis underlying the effectiveness of SGFD still remains unclear.

Aim Of The Review: This study aims to elucidate the material basis of SGFD through the application of network pharmacology and biological affinity ultrafiltration.

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Polysaccharides have a significant impact on the physicochemical properties of starch, and the objective of this study was to examine the effect of incorporating soluble soybean polysaccharide (SSPS) on the gelatinization and retrogradation of corn starches (CS) with varying amylose content. In contrast to high-amylose corn starch (HACS), the degree of gelatinization of waxy corn starch (WCS) and normal corn starch (NCS) decreased with the addition of SSPS. The inclusion of SSPS resulted in reduced swelling power in all CS, and led to a decrease in gel hardness of the starches.

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Article Synopsis
  • The extraction of polysaccharides from Bletilla striata was optimized using advanced methods like Box-Behnken design and a genetic algorithm, resulting in improved yields and antioxidant activity.
  • Optimal parameters for extraction were determined: a liquid-to-solid ratio of 15 mL/g, extraction power of 450 W, and an extraction time of 34 minutes, yielding 8.29% polysaccharide content.
  • The purified polysaccharide (pBSP1) demonstrated good structural and thermal stability and showed potential protective effects on intestinal cells against stress induced by lipopolysaccharides.
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Based on network pharmacology and molecular docking, this study seeks to investigate the mechanism of Taohong Siwu decoction (THSWD) in the treatment of avascular necrosis of the femoral head (AVNFH). The Traditional Chinese Medicine Systems Pharmacology database was used in this investigation to obtain the active ingredients and related targets for each pharmaceutical constituent in THSWD. To find disease-related targets, the terms "avascular necrosis of the femoral head," "necrosis of the femoral head," "steroid-induced necrosis of the femoral head," "osteonecrosis," and "avascular necrosis of the bone" were searched in the databases DisGeNET, GeneCards, Comparative Toxicogenomics Database, and MalaCards.

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  • The study presents an advanced distributed acoustic sensor that utilizes time-frequency-multiplexing (TFM) with optical frequency domain reflectometry (OFDR) for improved spatial resolution.
  • TFM enhances the frequency response and reduces crosstalk, while high sensitivity is achieved through phase demodulation and end effects are mitigated using linear interpolation.
  • Experimental results demonstrate the system's effectiveness, measuring a 10.5 kHz vibration with a spatial resolution of 22 cm and good performance at a 33 kHz vibration with a sampling rate up to 200 kHz over a 1 km fiber.
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Osteoporosis is a prevalent age-related disease that poses a significant public health concern as the population continues to age. While current treatments have shown some therapeutic benefits, their long-term clinical efficacy is limited by a lack of stable curative effects and significant adverse effects. Traditional Chinese Medicine has gained attention due to its positive curative effects and fewer side effects.

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The state of polarization is essential for a full description of ultrashort pulses. We experimentally observe the transient vector dynamics of pulsating vector solitons with rotating polarizations in a single-wall carbon nanotube mode-locked fiber laser. We acquire the single-shot polarization evolution of two different dual soliton pulsations using a homemade real-time wavelength-resolved state of polarization measurement system.

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Based on network pharmacology methods, we explored the mechanism of the classic Chinese medicine formula Coix seed decoction (CSD) in treating knee osteoarthritis (KOA). We searched each single drug in the CSD in the traditional Chinese medicine systematic pharmacology database in turn to obtain information on the active ingredients and target proteins of the CSD, and obtain the name of the genes corresponding to the target proteins through the UniProt database. We collected KOA-related genes from DisGeNET, GeneCards, comparative toxicogenomics database, and MalaCards database.

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  • The study investigates the clinical use of Akebiae Caulis, specifically differentiating between two varieties: Akebia quinata (SAQ) and Akebia trifoliata (SAT).
  • Various scientific techniques, including organoleptic evaluation, microscopic observation, and machine learning models, were employed to analyze and identify key physical and chemical characteristics of the two plant types.
  • Results showed distinct differences in composition and antioxidant properties, with SAQ and SAT exhibiting varying levels of effectiveness, thus highlighting the importance of accurate identification in clinical applications.
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  • Atractylodis Macrocephalae Rhizoma (AMR) is a plant widely used in health products, containing many polysaccharides that have yet to be fully utilized.
  • The study optimized extraction methods for Atractylodis Macrocephalae Rhizoma polysaccharide (AMRP) using various neural network models and found that the best extraction conditions yielded 31.31% AMRP.
  • Characterization techniques revealed AMRP's structure, showing it has a rough outer surface, porous interior, high levels of glucose, arabinose, and galactose, and demonstrated its potential as an antioxidant in lab experiments.
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Osteoarthritis (OA) causes pain and disability in the elderly and has placed a severe burden on healthcare worldwide. Excessive death and decreased density of chondrocytes are recognized as the major pathological characteristic of OA. Chondrocytes have been shown to have multiple forms of death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

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As a clinical empirical prescription for ophthalmology, compound chrysanthemum has been used gradually and has a good effect on eye fatigue. However, the detailed mechanisms of antiasthenopia have not been studied. In order to clarify the mechanisms of the compound chrysanthemum in the treatment of asthenopia, network pharmacology was combined with experimental study in this paper.

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It is the key to control bio-derived dissolved organic matters (DOM) in order to reduce the effluent concentration of wastewater treatment, especially for waste leachate with high organic contaminants. In the present study, the anaerobic degradation of aerobically stabilized DOM was investigated with DOM substrate isolated through electrodialysis. The degradation of bio-derived DOM was confirmed by reduction of 15% of total organic carbon in 100 days.

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The processes combining biological treatment with membrane separation technologies have been widely adopted for leachate treatment. However, dissolved organic matter (DOM) of leachate membrane concentrates generated from various membrane separation technologies has not been systematically investigated in field scale. Therefore, substance flow analysis based on DOM molecular information of leachate membrane concentrates from primary membrane systems (i.

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A 4-set Venn diagram model oriented to high-resolution mass spectrometry (HRMS) data was developed to decipher the fate of dissolved organic matters (DOM) in three-stage continuous wastewater treatment processes. In total, 24 typical wastewater treatment modes conceptualized into a combination of three stages were generalized so that this model can be applied to all common types of actual wastewater treatment processes. As a result, eight kinds of native DOM and seven kinds of wastewater-produced (WW-produced) DOM separately represented by each proper subset of the 4-set Venn diagram could be identified so as to offer a molecular profile of DOM transformation.

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Currently, interventional therapy has been widely used in clinical practice as a treatment method for hepatocellular carcinoma (HCC). The limitations of interventional therapy lie mainly in the intolerable pain felt by the patients during the treatment process. Hence, the selection of the anesthetic methods and drugs, as well as the precise control of the dosages, are particularly crucial before the initiation of the treatment.

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Previous study suggests that gratitude intervention evokes indebtedness among people from an interdependent society. This study furtherly hypothesized that perceived social distance moderates the effect of gratitude intervention on felt indebtedness. A total of 275 adolescents were randomly assigned to three gratitude intervention conditions, namely, writing gratitude to significant others, the health of one's own, or nothing.

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C-reactive protein (CRP) participates in human inflammatory responses and is an important indicator in clinical diagnoses. At present, the use of monoclonal antibodies to detect CRP in the human body is high, but they are unstable and expensive. Understanding the CRP expression pathway is of great significance for developing CRP tests and reagents.

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