Publications by authors named "Junjie Luo"

Background: Angiogenesis is one of the important factors related to tumorigenesis, invasion, and metastasis. Cancer-secreted exosomes are essential mediators of intercellular cross-talk and participate in angiogenesis and metastasis. Unveiling the mechanism of angiogenesis is an important way to develop anti-angiogenesis therapeutic strategies to against cancer progression.

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Pneumatic oscillators, incorporating soft non-electrical logic gates, offer an efficient means of actuating robots to perform tasks in extreme environments. However, the current design paradigms for these devices typically feature uniform structures with low rigidity, which restricts their oscillation frequency and limits their functions. Here, we present a pneumatic hybrid oscillator that integrates a snap-through buckling beam, fabric chambers, and a switch valve into its hybrid architecture.

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The Simulator of Human Intestinal Microbial Ecosystem (SHIME) has hindered widespread adoption due to its high cost. This study founded biomimetic multilink fermentation equipment (BMLFE), priced at half or even lower than SHIME. It was improved based on multilink fermentation equipment (MLFE) by modifying materials, peristaltic pumps, fermentation time, and dietary habits while calculating transfer time and volumes and conducted anaerobic fermentation for 15 days followed by monitoring changes in intestinal microbial composition and short-chain fatty acids (SCFAs).

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: Polyphenol is considered to exert a favorable impact on cardiovascular health. : To summarize the role of polyphenol antioxidant supplements in cardiovascular disease, we searched for randomized controlled trials up to 10th November 2024 that reported estimates of the effects of polyphenol antioxidant supplements on cardiometabolic risk factors. : Of the 17,126 participants in the 281 studies, weighted mean differences [95% confidence intervals] were derived for the intervention condition utilizing random effects modeling.

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The pigmentation of various components leads to different colors of roses. However, the intricate molecular machinery and metabolic pathways underlying rose pigmentation remain largely unexplored. In this study, we determined that pink and black-red petals contain abundant anthocyanins, reaching concentrations of 800 μg/g and 1400 μg/g, respectively, significantly surpassing those in white and yellow petals.

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Article Synopsis
  • The study aimed to analyze the significance of high-intensity signals in interspinous ligaments in patients with degenerative lumbar spondylolisthesis (DLS) and to identify the best diagnostic methods for assessing segmental instability.
  • A total of 73 patients were assessed, divided into two groups based on the presence of high-intensity signals, with Group H showing more functional impairment and longer 5-repetition sit-to-stand test times compared to Group NH.
  • The results indicated that instability was more prevalent in Group H (77.3%) compared to Group NH (37.3%), suggesting that high-intensity signals correlate with more severe segmental instability in DLS.
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  • * It introduces a method called Two-step Progressive Registration (TSPR), which uses specific anatomical features and contours to accurately register clinical CT/MRI datasets with the Chinese Visible Human (CVH) dataset for ROI localization.
  • * TSPR is adaptable to the real-world conditions of clinical data, effectively handles problems like organ deformation, and promotes better learning and access to medical services for students, researchers, and patients, enhancing digital public health and education.
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The efficacy of functional lipids with antioxidant properties in reducing cardiovascular risk has not been consistent. Randomized controlled trials (RCTs) reporting estimates for the effects of antioxidant functional lipid supplementations on cardiometabolic risk factors were searched up to 1 May 2024. Overall, antioxidant lipid supplementations, compared with placebo, had favorable effects on systolic blood pressure (lycopene: -1.

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  • Natural hybridization is important for biodiversity, especially in ferns, but there's still a lack of understanding of how it works in these plants.
  • The study uses advanced genetic techniques to analyze the hybridization origins of the fern species M. matthewii and its potential parental species, looking at nuclear and chloroplast genetic markers.
  • Results indicate that M. matthewii shows a mixed genetic profile from its parent species, with significant evidence of gene flow, suggesting it is a hybrid that does not follow a 1:1 parentage ratio and exhibits complex hybridization dynamics.
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  • Animals make decisions based on both innate sensory cues and learned information, but the interaction between these two types of memory is not fully understood.
  • The study investigates how dopamine neurons in the Drosophila brain manage both innate and learned sensory valences, affecting memory processes during olfactory conditioning.
  • Findings indicate that specific dopamine neurons regulate short- and long-term memory formation, with implications for understanding memory dynamics in other species.
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Yu Liu, Zhengyang Zhang, Yongting Luo, Peng An, Jingyi Qi, Xu Zhang, Shuaishuai Zhou, Yongzhi Li, Chong Xu, Junjie Luo, and Jiaping Wang. Product of traditional Chinese medicine longgui yangxinwan protects the human body from altitude sickness damage by reducing oxidative stress and preventing mitochondrial dysfunction. 26:20-29, 2025.

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Background: Sarcopenia is an age-related condition characterized by progressive loss of muscle mass, strength, and function. The occurrence of sarcopenia has a huge impact on physical, psychological, and social health. Therefore, the prevention and treatment of sarcopenia is becoming an important public health issue.

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  • - The study assessed the effects of high-quality protein supplements (soy, milk, whey, and casein) on cardiovascular disease (CVD) risk factors through a comprehensive search of multiple scientific databases.
  • - Results showed that all protein types contributed to lowering systolic blood pressure, total cholesterol, and LDL cholesterol, with whey showing the most significant improvements in cardiometabolic health.
  • - Specifically, soy and milk proteins were effective in reducing blood pressure and cholesterol, while whey protein also positively influenced triglycerides and fasting blood insulin levels, with variations depending on individuals' health status (such as hypertension and obesity).
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The liver plays a crucial role in maintaining systemic iron homeostasis by secreting hepcidin, which is essential for coordinating iron levels in the body. Imbalances in iron homeostasis are associated with various clinical disorders related to iron deficiency or iron overload. Despite the clinical significance, the mechanisms underlying how hepatocytes sense extracellular iron levels to regulate hepcidin synthesis and iron storage are not fully understood.

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Background And Objectives: The current widely utilized clinical approach for severe intraventricular hemorrhage involves ventriculostomy with supportive drainage. The aim of our study was to evaluate the overall efficacy of neuroendoscopic hematoma removal combined with ventricular lavage as a treatment approach for severe intraventricular hemorrhage.

Methods: A prospective randomized controlled study was conducted, selecting a total of 98 patients with severe intraventricular hemorrhage at our hospital from February 2021 to November 2022.

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Background: The discovery of traditional plants' medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant polysaccharide (DOP) on atherosclerosis is still not elucidated.

Purpose: This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE) mice.

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Background: Bones undergo a constant remodeling, a process involving osteoclast-mediated bone resorption and osteoblast-mediated bone formation, crucial for maintaining healthy bone mass. We previously observed that miR-185 depletion may promote bone formation by regulating Bgn expression and the BMP/Smad signaling pathway. However, the effects of miR-185-5p on the osteoclasts and bone remodeling have not been elucidated, warranting further exploration.

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Soft grippers due to their highly compliant material and self-adaptive structures attract more attention to safe and versatile grasping tasks compared to traditional rigid grippers. However, those flexible characteristics limit the strength and the manipulation capacity of soft grippers. In this paper, we introduce a hybrid-driven gripper design utilizing origami finger structures, to offer adjustable finger stiffness and variable grasping range.

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Mutations of the gene lead to Marfan syndrome (MFS), which is an autosomal dominant connective tissue disorder featured by thoracic aortic aneurysm risk. There is currently no effective treatment for MFS. Here, we studied the role of mitochondrial dysfunction in the phenotypic transformation of human smooth muscle cells (SMCs) and whether a mitochondrial boosting strategy can be a potential treatment.

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Distant metastasis is the main cause of death in patients with colorectal cancer (CRC). A better understanding of the mechanisms of metastasis can greatly improve the outcome of patients with CRC. Accumulating evidence suggests that circRNA plays pivotal roles in cancer progression and metastasis, especially acting as a miRNA sponge to regulate the expression of the target gene.

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Inconsistent findings exist regarding the relationship between heme iron intake and type 2 diabetes (T2D) among Western and Eastern populations. Easterners tend to consume a plant-based diet which is abundant in antioxidant minerals. To examine the hypothesis that antioxidant mineral may modify the relationship between iron and T2D, we performed a case-control study by measuring the serum mineral levels in 2198 Chinese subjects.

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Liquid-liquid phase separation (LLPS) impact immune signaling in cancer and related genes have shown prognostic value in breast cancer (BRCA). However, the crosstalk between LLPS and immune infiltration in BRCA remain unclear. Therefore, we aimed to develop a novel prognostic model of BRCA related to LLPS and immune infiltration.

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Background: Patients with triple-negative breast cancer (TNBC) often have a poor prognostic outcome. Current treatment strategies cannot benefit all TNBC patients. Previous findings suggested pyroptosis as a novel target for suppressing cancer development, although the relationship between TNBC and pyroptosis-related genes (PRGs) was still unclear.

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Background And Aims: Stanford type A aortic dissection (AD) is a degenerative aortic remodelling disease marked by an exceedingly high mortality without effective pharmacologic therapies. Smooth muscle cells (SMCs) lining tunica media adopt a range of states, and their transformation from contractile to synthetic phenotypes fundamentally triggers AD. However, the underlying pathomechanisms governing this population shift and subsequent AD, particularly at distinct disease temporal stages, remain elusive.

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