Current Understanding and Translational Prospects of Tetrahedral Framework Nucleic Acids.

Tetrahedral framework nucleic acids (tFNAs) represent a promising advancement in nucleic acid nanotechnology due to their unique structural properties, high biocompatibility, and multifaceted biomedical applications. Constructed through a one-pot annealing method, four single-stranded DNAs self-assemble into stable, three-dimensional tetrahedral nanostructures with enhanced mechanical robustness and physiological stability, resisting enzymatic degradation. Their ability to permeate mammalian cells without transfection agents, coupled with modifiable surfaces, positions tFNAs as versatile carriers for drug and gene delivery systems.

Advances of microalgae-based enhancement strategies in industrial flue gas treatment: From carbon sequestration to lipid production.

The acceleration of industrial development and urban expansion has led to a significant increase in flue gas emissions, posing a significant risk to human health and ecosystems. Recent studies have elucidated the significant potential of microalgae in the domain of sustainable industrial flue gas treatment. However, the inherent multifaceted factors within flue gas exert inhibitory effects on microalgal growth, thereby diminishing the overall system efficacy.

Fumonisins in maize and its products from Dalian region, China, and risk assessment by deterministic and probabilistic approaches.

A total of 76 samples of maize and its products were collected in 2022-2023 to estimate dietary exposure of fumonisins (FBs) in Dalian region, China. The identification of FBs was performed by ultrahigh performance liquid chromatography coupled with mass spectrometry (UPLC-MS/MS). The occurrences of FB, FB, FB, FB + FB + FB were 89.

Integrating Ultra-High-Performance Liquid Chromatography and Orbitrap High-Resolution Mass Spectrometry, Feature-Based Molecular Networking, and Network Medicine to Unlock Harvesting Strategies for Endangered Sinocalycanthus Chinensis.

Evaluating the practical utility of endangered plant species is crucial for their conservation. Nevertheless, numerous endangered plants, including Sinocalycanthus chinensis, lack historical usage data, leading to a paucity of guidance in traditional pharmacological research. This gap impedes their development and potential utilization.

Atezolizumab plus bevacizumab in patients with unresectable or metastatic mucosal melanoma: 3-year survival update and multi-omics analysis.

Background: Atezolizumab plus bevacizumab has shown promising efficacy in advanced mucosal melanoma in the multi-centre phase II study. This report updates 3-year survival outcomes and multi-omics analysis to identify potential response biomarkers.

Methods: Forty-three intention-to-treat (ITT) patients received intravenous administration of atezolizumab and bevacizumab every 3 weeks.

Two new species of Interphasma Chen & He, 2008 (Phasmatodea: Phasmatidae: Clitumninae) from Yunnan, China.

Two new species of Interphasma Chen & He, 2008 are described in this article from Yunnan, China. Interphasma monticola sp. nov.

Expression of integrin α4β1 and α4β7 on B cells correlates with autoimmune responses in Graves' disease.

Background: Integrins are upregulated on endothelial cells and T-lymphocytes in autoimmune thyroid disease (AITD), potentially contributing to immune response localization. The role of integrins on B-cells in AITD remains unclear.

Methods: Peripheral blood samples were collected from healthy controls (n = 56), patients with Graves' disease (GD) (n = 37) and Hashimoto's thyroiditis (HT) (n = 52).

New Genera and Species of Trigonidiidae (Orthoptera: Grylloidea) from the Mid-Cretaceous of Myanmar with a Redescription of .

The abundance of insects in Burmese amber illustrates a highly diverse insect community from the mid-Cretaceous period; yet, records of crickets (Grylloidea) are notably scarce. In this study, we describe two new genera with three new species, gen. et sp.

Systematics Review and Phylogeny of Cyrtophyllitinae Zeuner, 1935 Gorochov, Jarzembowski & Coram, 2006 (Ensifera, Haglidae), with Description of Two New Species.

A phylogeny of Cyrtophyllitinae Zeuner, 1935 Gorochov, Jarzembowski & Coram, 2006, based on wing morphology, is presented including all genera. Cyrtophillitinae is found to be paraphyletic. Except for Oppenheim, 1888, all other species were moved from the subfamily Cyrtophyllitinae (Hagloidea, Haglidae).

Evolving cancer resistance to anti-PD-1/PD-L1 antibodies in melanoma: Comprehensive insights with future prospects.

Immunotherapy has transformed the treatment of advanced melanoma. However, up to two-thirds of patients experience disease progression after initially achieving a response to immunotherapy. Furthermore, most research has focused on cutaneous melanoma rather than acral or mucosal melanoma, although the latter predominates in Asian populations.

PPARγ Antagonists Exhibit Antitumor Effects by Regulating Ferroptosis and Disulfidptosis.

Oral squamous cell carcinoma (OSCC) stands as a prevalent subtype of head and neck squamous cell carcinoma, leading to disease recurrence and low survival rates. PPARγ, a ligand-dependent nuclear transcription factor, holds significance in tumor development. However, the role of PPARγ in the development of OSCC has not been fully elucidated.

A new genus and a new species of pygmy mole cricket from mid-Cretaceous amber in North Myanmar (Orthoptera: Caelifera: Tridactyloidea).

This paper describes a new genus with a new species from Burmese amber, namely: Latedactylus longapedi gen. et sp. nov.

A new genus and a new species of Trigonidiidae (Orthoptera: Grylloidea) from north Myanmar amber.

We present the description of a new genus and new species of Trigonidiidae, Qiongqi crinalis gen. et sp. nov.

Pteronemobius yuani Ma & Wang sp. nov. and Metiochodes tianfuensis Ma, Yuan & Gu sp. nov., new species of Trigonidiidae from China (Orthoptera: Trigonidiidae; Trigonidiinae).

The article describes two new species of Trigonidiidae Saussure, 1874, namely Pteronemobius yuani Ma & Wang sp. nov. and Metiochodes tianfuensis Ma, Yuan & Gu sp.

Flocculation under combined effects of hydrodynamic and subaqueous biomass in the bottom boundary layer (BBL) of a microtidal estuary.

The flocculation dynamics within the bottom boundary layer (BBL) of tidal estuaries constitute a pivotal and intricate aspect entwined with hydrodynamics and morphodynamics. In microtidal estuaries, where saltwater intrusion occurs, the ensuing impacts on ecosystems, biological habitats, and human activities underscore necessity for comprehensive understanding. In pursuit of elucidating flocculation dynamics within estuarine BBLs, an extensive 25-hour survey was conducted throughout a complete tidal-cycle in the Huangmaohai estuary, China.

Reactive Matrices for MALDI-MS of Cholesterol.

Cholesterol is a critical molecule whose dysregulation in certain brain regions is related to multiple neurological disorders. It is of pathological importance to map the distribution of cholesterol in brain. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been widely used in the molecular imaging of metabolites at a high spatial resolution.

A new method for examining the co-occurrence network of fossil assemblages.

Currently, studies of ancient faunal community networks have been based mostly on uniformitarian and functional morphological evidence. As an important source of data, taphonomic evidence offers the opportunity to provide a broader scope for understanding palaeoecology. However, palaeoecological research methods based on taphonomic evidence are relatively rare, especially for body fossils in lacustrine sediments.

A new species of the genus Burmadactylus Heads, 2009 from mid-Cretaceous amber in north Myanmar (Orthoptera: Caelifera: Tridactyloidea).

This paper describes a new species of the genus Burmadactylus Heads, 2009 (Tridactylidae: Dentridactylinae) from Burmese amber, namely: Burmadactylus tenuicerci sp. nov. This new species is similar to Burmadactylus grimaldi Heads, 2009, but differs from latter by mesotibia basally inflated and almost as long as mesofemur; the second segment of cercus distinctly slender; paraproctal lobe covered with sparse and slender setae, one of the setae near the apex distinct thick and long.

Remote cardiac rehabilitation program during the COVID-19 pandemic for patients with stable coronary artery disease after percutaneous coronary intervention: a prospective cohort study.

Objective: The coronavirus disease-19 (COVID-19) pandemic restricts rapid implementation of in-person delivery of cardiac rehabilitation (CR) at the center for coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI), thus enabling a cohort comparison of in-person vs. remote CR program. This study aims to investigate outcomes of exercise capacity, health-related quality of life (HRQL), mental health, and family burden of stable CAD patients undergoing PCI in low-to-moderate risk after different delivery models of CR program.

Effect of mindfulness-based stress reduction in patients with acute myocardial infarction after successful primary percutaneous coronary intervention: a retrospective study.

Objective: This study aimed to examine the effects of mindfulness-based stress reduction (MBSR) in patients with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PPCI).

Methods: A retrospective study was conducted with data collected from AMI patients who underwent successful PPCI. The study included 61 cases that received 8-week MBSR intervention (MBSR group) and 61 cases that received weekly health education (control group) over the same period.

Ni electrodes with 3D-ordered surface structures for boosting bubble releasing toward high current density alkaline water splitting.

The performance of alkaline water electrolysis (AWE) at high current densities is limited by gas bubble generation on the surface of electrodes, which covers active sites and blocks mass transfer, resulting in lower AWE efficiency. Here, we utilize electro-etching to construct Ni electrodes with hydrophilic and aerophobic surfaces to improve the efficiency of AWE. Ni atoms on the Ni surface can be exfoliated orderly along the crystal planes by electro-etching, forming micro-nano-scale rough surfaces with multiple crystal planes exposed.

Efficacy of dynamic interpersonal therapy for major depressive disorder in China: results of a multicentered, three-arm, randomized, controlled trial.

Background: Dynamic interpersonal therapy (DIT) is a brief, structured psychodynamic psychotherapy with demonstrated efficacy in treating major depressive disorder (MDD). The aim of the study was to determine whether DIT is an acceptable and efficacious treatment for MDD patients in China.

Method: Patients were randomized to 16-week treatments with either DIT plus antidepressant medication (DIT + ADM; = 66), general supportive therapy plus antidepressant medication (GST + ADM; = 75) or antidepressant medication alone (ADM; = 70).