Immune-related thyroid dysfunction as a positive prognostic factor for patients with lung cancer in China: a real-world retrospective study.

Introduction: The relationship between immune-related thyroid dysfunction (irTD) and survival rates in cancer patients remains unclear. Furthermore, the impact of variations in immunotherapy line numbers and pathological types among lung cancer patients on this relationship has not been fully elucidated. This study aims to evaluate the potential of irTD as a prognostic marker for immunotherapy in Chinese patients with lung cancer.

Construction of a prognostic model for extensive-stage small cell lung cancer patients undergoing immune therapy in northernmost China and prediction of treatment efficacy based on response status at different time points.

Background And Purpose: Recently, the emergence of immune checkpoint inhibitors has significantly improved the survival of patients with extensive-stage small cell lung cancer. However, not all patients can benefit from immunotherapy; therefore, there is an urgent need for precise predictive markers to screen the population for the benefit of immunotherapy. However, single markers have limited predictive accuracy, so a comprehensive predictive model is needed to better enable precision immunotherapy.

Enhanced fiber-coupling efficiency via high-order partially coherent flat-topped beams for free-space optical communications.

The fiber-coupling efficiency of signal beams is crucial in free space optical (FSO) communications. Herein, we derived an analytical expression for the fiber-coupling efficiency of partially coherent flat-topped beams propagating through atmospheric turbulence based on the cross-spectral density function. Our numerical calculation results showed that the fiber-coupling efficiency of partially coherent flat-topped beams in a turbulent atmosphere could be enhanced by increasing the beam order.