Extracellular Vesicle-Like Nanovesicle for Skin Photoaging Therapy.

Ultraviolet (UV) irradiation leads to the degradation of the extracellular matrix and collagen, thereby accelerating skin aging and imposing substantial psychological burden on patients. Current anti-aging strategies are limited and often associated with high costs or strong side effects. Plant-derived extracellular vesicle-like nanovesicles, with advantages such as natural availability and cost-effectiveness, show potential in anti-aging interventions.

Involvement of copper in cell death and cancer.

Copper (cu) is an essential micronutrient required for numerous metabolic processes. It plays a crucial role in cellular respiration by participating in the electron transport chain and facilitating numerous biological reactions. Various diseases, including cancer, demonstrate localized elevation of copper levels and/or alterations in the overall distribution of copper.

Elongation and branching of stem channels produced by positive streamers in long air gaps.

The elongation and branching of long positive spark discharges in the laboratory and in lightning have been attributed to the formation of thermalized channels inside a diffuse, glow-like streamer section at the leader head. It is experimentally shown here that the structured morphology of streamers produce low-density stem channels that elongate and branch well before a new leader channel section is formed. These non-thermalized stems are also shown to develop ahead of a developing leader channel.

Prevalence and risk analysis of mobile colistin resistance and extended-spectrum -lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study.

Mobile colistin resistance gene and extended-spectrum -lactamase gene are highly prevalent in human - and pet-derived bacteria. Isolation of identical strains of -positive (MCRPEC) or -positive (CTX-MPEC) from pets and humans highlighted the potential for co-colonization of antibiotic-resistant bacteria which can be a risk for dissemination of resistance genes. In this study, the prevalence of and carriage from rectal swabs in 299 families (dogs and their owners) were 2.

Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms.

The discovery of plasmid-mediated tet(X) variants and efflux pump gene tmexCD1-toprJ1 conferring bacteria resistance to tigecycline has compromised glycylcycline as the last line of defense against infection, which poses serious threat to public health. Herein, real-time quantitative PCR was used to detect the abundance of seven tigecycline resistance genes (TRGs), including six tet(X) variants and tmexCD1-toprJ1, and insertion sequences ISCR2 and IS26. Then, the concentrations of nine antibiotics were quantified in fecal samples collected from 157 livestock farms in four Chinese provinces.

Prevalence, etiology, and economic impact of clinical mastitis on large dairy farms in China.

This study investigated the continuous monthly prevalence of bovine clinical mastitis (CM) and the distribution of causative pathogens among 36,619 CM milk samples from large dairy farms across seven Chinese provinces from 2015 to 2017 using data from routine CM recording systems. Based on treatment period and cost per cow, withdrawal period, daily milk production, and milk value data from each farm in 2017, we calculated the economic impact of CM at the farm level with 2578-9044 lactating cows per farm. Results showed a wide variation in monthly prevalence of CM (0.

Co-existence of two novel phosphoethanolamine transferase gene variants in Aeromonas jandaei from retail fish.

Two novel phosphoethanolamine transferase genes, eptAv7 and eptAv3, were identified in the chromosome of an Aeromonas jandaei isolate from retail fish. The variants showed 79.9% and 80.

Inter-host Transmission of Carbapenemase-Producing among Humans and Backyard Animals.

Background: The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied.

Objectives: We investigated the prevalence, risk factors, and drivers of CRE transmission between humans and their backyard animals in rural China.

Integrated aquaculture contributes to the transfer of mcr-1 between animals and humans via the aquaculture supply chain.

Background: Since its discovery in 2015, the mobile colistin resistance gene mcr-1 has been reported in bacteria from >50 countries. Although aquaculture-associated bacteria may act as a significant reservoir for colistin resistance, systematic investigations of mcr-1 in the aquaculture supply chain are scarce.

Objectives: We investigated the presence of colistin resistance determinants in the aquaculture supply chain in south China and determined their characteristics and relationships.

Characterization of multiresistance gene cfr(C) variants in Campylobacter from China.

Objectives: To investigate the occurrence, the genetic environment and the functionality of novel variants of the MDR gene cfr(C) in Campylobacter from China.

Methods: A total of 370 Campylobacter isolates of porcine and chicken origin collected from three regions of China in 2015 were screened for cfr(C) by PCR. The phenotypes and genotypes of cfr(C)-positive isolates were investigated by antimicrobial susceptibility testing, PFGE, MLST, S1-PFGE, Southern blotting and WGS.

A New Denoising Method for UHF PD Signals Using Adaptive VMD and SSA-Based Shrinkage Method.

Noise suppression is one of the key issues for the partial discharge (PD) ultra-high frequency (UHF) method to detect and diagnose the insulation defect of high voltage electrical equipment. However, most existing denoising algorithms are unable to reduce various noises simultaneously. Meanwhile, these methods pay little attention to the feature preservation.

Association of colistin residues and manure treatment with the abundance of mcr-1 gene in swine feedlots.

Background: The extensive use of colistin in swine production may have contributed to the recent emergence of corresponding mobile resistance gene mcr-1. The use of colistin as a feed additive was banned in China in April 2017.

Objectives: To examine the occurrence of colistin and dissemination of mcr-1 in swine feedlots before and after the colistin ban and effects of different manure treatments.

Genetic environment of colistin resistance genes mcr-1 and mcr-3 in Escherichia coli from one pig farm in China.

The aim of this study was to assess the presence of mobile colistin resistance in bacteria isolated from the swine production environment and to analyze the genomic environment of the new colistin resistance gene mcr-3. Anal swabs and environmental samples were collected from a commercial pig farm. Direct sample testing (DST) for mcr genes and isolation of colistin-resistant isolates was performed.

Research on ultra-fast vacuum mechanical switch driven by repulsive force actuator.

In order to meet the fast operation demands of DC circuit breakers, a high-speed vacuum mechanical switch (VMS) driven by a repulsive force actuator is focused. To improve the drive speed and energy conversion efficiency (ECE) of the actuators, the dynamic characteristics of the double sided coil repulsive force actuators are investigated, and two generalized optimization design methods focusing on the aspect ratio of the driving coils (defined as ARF) and the electrical parameters (defined as EF) are developed. FEM simulation models' simulation and tests of VMS prototypes are conducted to verify the optimization methods.

Digital time-resolved optical measurement of discharge currents in long air gaps.

Shortcomings in the dynamic range and the frequency bandwidth of current diagnostic methods mean that measurement of the time-resolved discharge current in a long air gap discharge is still a serious problem. This work presents data from a novel discharge current sensor that takes the parameters required to determine the accuracy of the current measurement into account. The design of a coaxial current sensor with ±0.

On-line estimation of laser-drilled hole depth using a machine vision method.

The paper presents a novel method for monitoring and estimating the depth of a laser-drilled hole using machine vision. Through on-line image acquisition and analysis in laser machining processes, we could simultaneously obtain correlations between the machining processes and analyzed images. Based on the machine vision method, the depths of laser-machined holes could be estimated in real time.

[Development of a nitric oxide supply system for respiratory distress treatments].

College of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan,430074 Inhaled nitric oxide (INO) is increasingly being used in medical treatments of high blood pressure, acute respiratory distress syndrome (ARDS) and some diseases related with lungs. In this paper, in view of the problems in the current supply systems of NO for the treatments of respiratory failure, an INO system for clinical applications is designed based on experimental studies. Its continuous trial run shows that the outlet concentration of NO can be supplied constantly, and the ratio of NO2/NO is about 2.