Sedanolide Activates KEAP1-NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death.

Sedanolide is a bioactive compound with anti-inflammatory and antitumor activities. Although it has been recently suggested that sedanolide activates the nuclear factor E2-related factor 2 (NRF2) pathway, there is little research on its effects on cellular resistance to oxidative stress. The objective of the present study was to investigate the function of sedanolide in suppressing hydrogen peroxide (HO)-induced oxidative damage and the underlying molecular mechanisms in human hepatoblastoma cell line HepG2 cells.

Relationship between Facial Color Changes and Psychological Problems Associated with Lower Back Pain.

: The aim of this study was to determine whether a non-contact sensor that detects complexion changes can be used to assess the psychological state of patients with chronic lower back pain (LBP). : Twenty-six patients with LBP (LBP group; mean age = 68.0 ± 13.

Pain Evaluation During Colonoscopy by the Erythema Index of the Facial Image.

Background: Endoscopy of the digestive tract is useful but is associated with significant pain to the patient. Its safety and tolerability could be improved by an immediate and objective method to evaluate the pain level and give feedback to the examiner. However, under the current circumstances, it is difficult to measure and assess the pain level objectively.

Influence on human sleep patterns of lowering and delaying the minimum core body temperature by slow changes in the thermal environment.

Study Objectives: We hypothesized that appropriate changes in thermal environment would enhance the quality of sleep.

Design/setting: Controlled laboratory study.

Participants: Healthy young men (n = 7, mean age 26 years).