Publications by authors named "Junichi Terashima"
Article Synopsis
- The study focuses on the effectiveness of the combination of dabrafenib and trametinib for treating pediatric high-grade gliomas (pHGG) with the V600 mutation, which is found in 5%-10% of such cases and has limited treatment options.
- It was a phase II trial involving 41 pediatric patients, and results showed a 56% overall response rate (ORR), with a median duration of response of 22.2 months and a median overall survival of 32.8 months.
- The findings indicate that this treatment combination may offer better outcomes compared to traditional chemotherapy, representing a potential targeted therapy for affected children and adolescents with relapsed or refractory V600-mutant HGG.*
Purpose: Complicated gastric lymphatic drainage potentially undermines the utility of sentinel node (SN) biopsy in patients with gastric cancer. Encouraged by several favorable single-institution reports, we conducted a multicenter, single-arm, phase II study of SN mapping that used a standardized dual tracer endoscopic injection technique.
Patients And Methods: Patients with previously untreated cT1 or cT2 gastric adenocarcinomas < 4 cm in gross diameter were eligible for inclusion in this study.