Publications by authors named "Junichi Hoshino"
Background: Iron deficiency is a major contributor to anaemia in chronic kidney diseases. The association of anaemia and iron deficiency with health-related quality of life in Japanese patients with non-dialysis chronic kidney disease has not been examined. In this study, we evaluated anaemia and iron deficiency in patients with chronic kidney disease G3b-5 and examined their associations with health-related quality of life.
View Article and Find Full Text PDFThe association of physical activity with renal outcome and mortality in advanced chronic kidney disease (CKD; i.e., estimated glomerular filtration rate [eGFR] < 45 ml/min/1.
View Article and Find Full Text PDFBackground: This study assessed the association of pathological kidney lesions with cardiovascular events in biopsy-proven diabetic kidney disease (DKD) with type 2 diabetes.
Methods: This multicenter, retrospective study involved 244 patients with no previous cardiovascular events before biopsy, estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m at biopsy (baseline), and ≥ 1 year of observation after biopsy.
Article Synopsis
- The study focuses on the impact of SARS-CoV-2 on kidney transplant (KTx) recipients, highlighting limited data on their treatment and prognosis during the pandemic.
- Out of 282 KTx patients infected with the virus, 6.7% experienced severe outcomes, with certain underlying health conditions increasing the risk of complications.
- Treatment strategies evolved over time in response to new variants, with antiviral drugs being administered as they gained approval.
Article Synopsis
- Lower serum phosphate levels in autosomal dominant polycystic kidney disease (ADPKD) may hide the importance of high phosphate levels (hyperphosphatemia) in predicting kidney outcomes.
- A study with 235 ADPKD patients found that increased serum phosphate is a significant risk factor for kidney disease progression, with higher levels correlating with worse outcomes.
- The findings suggest that monitoring phosphate levels, especially when they exceed 3.5 mg/dL, is crucial for managing ADPKD, as they are linked to lower kidney survival rates.
We aimed to develop a novel method for measuring the complement-binding ability of anti-blood type antibodies (ab-Abs), the flow cytometry method for the complement C1q test (FCM-C1q) for detecting antibody-mediated rejection (AMR) caused by ab-Abs in ABO-incompatible kidney transplantation (ABOI-KTx). FCM-C1q distribution was surveyed in 44 healthy participants and 43 dialysis patients (Cohort A). The relationship between AMR and FCM-C1q levels was examined along with ab-Ab titers by the flow cytometry method for the IgG test (FCM-IgG) in 62 ABOI-KTx patients (Cohort B).
View Article and Find Full Text PDFIntroduction: The DAPA-CKD study showed a protective effect of dapagliflozin on kidney function in chronic kidney disease (CKD) patients with and without diabetes mellitus. Although dapagliflozin is expected to be effective also in CKD patients with autosomal dominant polycystic kidney disease (ADPKD), its efficacy and safety in this population remain unknown because ADPKD was an exclusion criterion in the DAPA-CKD study. Therefore, we evaluated the effects of dapagliflozin in CKD patients with ADPKD.
View Article and Find Full Text PDFIntroduction: The association of hemoglobin level at treatment initiation with renal and cardiovascular outcomes in patients with anemia in nondialysis-dependent (NDD) chronic kidney disease (CKD) is unclear.
Methods: This retrospective cohort study utilized 2 Japanese databases (Medical Data Vision Co. Ltd.
Key Points: Little is known about the clinicopathological characteristics and renal outcomes in the patients with gross hematuria (GH) after the vaccination. To fill a clinicopathological knowledge gap regarding vaccination and GH, we conducted a nationwide multicenter prospective cohort study. GH is more likely to occur in patients with IgA nephropathy, with a female bias, but without progressive exacerbation of renal function.
View Article and Find Full Text PDFEpigenetic mechanisms are considered to contribute to diabetic nephropathy by maintaining memory of poor glycemic control during the early stages of diabetes. However, DNA methylation changes in the human kidney are poorly characterized, because of the lack of cell type-specific analysis. We examined DNA methylation in proximal tubules (PTs) purified from patients with diabetic nephropathy and identified differentially methylated CpG sites, given the critical role of proximal tubules in the kidney injury.
View Article and Find Full Text PDFBackground: Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are major genetic polycystic kidney diseases that can progress to end-stage kidney disease (ESKD). Longitudinal data on the clinical characteristics associated with clinical outcomes in polycystic kidney disease (PKD), including the development of ESKD and cardiovascular disease (CVD) are lacking in Japan. To address this unmet need the authors are establishing a novel, web-based, Nationwide Cohort Registry Study-the Japanese Registry of PKD (JRP).
View Article and Find Full Text PDFArticle Synopsis
- 90% of the 49 enrolled patients carried pathogenic or suspected pathogenic variants in known polycystic disease genes.
- The research highlighted differences in organ volumes between patients with autosomal dominant polycystic kidney disease (ADPKD) and those with isolated PLD, indicating that some patients can experience severe liver disease without significant kidney involvement.
Article Synopsis
- In April 2022, insurance claims for exercise instruction during haemodialysis treatment were approved in Japan, prompting a study on its implementation.
- A survey sent to 4,257 haemodialysis facilities revealed that 33% offered exercise instruction, with 65% claiming the new fee, focusing on resistance and aerobic exercises.
- Although 39% of facilities reported adverse events related to exercise therapy, none were life-threatening, indicating a positive trend towards incorporating exercise into haemodialysis treatment.
Background: The number of marginal living kidney donors has increased. Medically complex donors who have hypertension, older age, or low estimated glomerular filtration rate (eGFR) have been more likely to be used.
Methods: We conducted a retrospective cohort study of living kidney donors at a single center.
Background: IgG4-related disease (IgG4-RD) is a fibroinflammatory disease that affects multiple organs, including the pancreas, lacrimal glands, salivary glands, periaortic/retroperitoneum, and kidney. Interstitial nephritis is a typical renal disorder associated with IgG4-RD, but membranous nephropathy is also seen in some cases.
Case Presentation: Herein we report on the case of a 77-year-old male patient with nephrotic syndrome and IgG4-related lung disease.
Introduction: Data on longitudinal trajectory of kidney function decline and fluctuation in albuminuria leading to end-stage kidney disease (ESKD) is sparse in patients with type 2 diabetes.
Methods: Using data from an observational study of patients with type 2 diabetes and biopsy-confirmed diabetic kidney disease (DKD), generalized additive mixed models (GAMMs) were performed to quantify patterns of longitudinal trajectory of estimated glomerular filtration rate (eGFR) decline to ESKD associated with repeated measures of urine albumin-to-creatinine ratio (ACR).
Results: Over a median follow-up period of 3.
Article Synopsis
- * A sample of 519 ADPKD patients was analyzed, revealing that older age (≥ 50 years), female sex, and hypertension are significant risk factors for aneurysms among those aged 50 and above.
- * Younger patients (under 50) with chronic kidney disease and a family history of aneurysms are also at risk, indicating that both kidney dysfunction and genetic factors play a role in the development of intracranial aneurysms.
A 37-year-old man with autosomal dominant polycystic kidney disease (ADPKD) was admitted to our hospital with a liver volume of 8,000 cm. Hepatic arterial embolization was performed using a microcoil but was ineffective. Eight years later, the hepatomegaly progressed to liver failure and death.
View Article and Find Full Text PDFBackground: Dialysis patients undergoing transcatheter aortic valve replacement (TAVR) face increased risk and have poorer outcomes than non-dialysis patients. Moreover, TAVR in dialysis patients using an alternative approach is considered extremely risky and little is known about the outcomes. We routinely perform minimum-incision transsubclavian TAVR (MITS-TAVR), which is contraindicated for transfemoral (TF) TAVR.
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- MABA is a serious and sometimes deadly infection, particularly dangerous for those with weakened immune systems, and can lead to rare complications like pneumothorax.
- A case study of a 69-year-old Japanese woman with an immune disorder highlighted a successful treatment for pneumothorax caused by a MABA pulmonary infection.
- The patient was treated with a combination of antibiotics, including amikacin, sitafloxacin, clofazimine, and azithromycin, achieving remission in three weeks, emphasizing the importance of adhering to microbial sensitivity testing for effective treatment.
Background: Tolvaptan, a vasopressin V2 receptor antagonist, is used for treating autosomal dominant polycystic kidney disease (ADPKD). We focused on changes in urinary osmolality (U-Osm) after tolvaptan initiation to determine whether they were associated with the therapeutic response to tolvaptan.
Methods: This was a single-centre, prospective, observational cohort study.