Publications by authors named "Junichi Hinagata"
Objective: LOX-1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. LOX-1 expression is also induced in smooth muscle cells in response to proinflammatory and oxidative stimuli. Here, we report on the role of LOX-1 in intimal hyperplasia, in which proinflammatory and oxidative stimuli are increased.
View Article and Find Full Text PDFLectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to play a role in the progression of atherogenesis. We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein. We compared the group of patients with myocardial infarction (MI) (n=102) with a group of clinically healthy subjects (n=102), and found that the MI group had a significantly high frequency of 501G/C+501C/C (38.
View Article and Find Full Text PDFArticle Synopsis
- The macrophage scavenger receptor (MSR) is a trimeric membrane protein that binds modified LDL and is linked to atherosclerosis development.
- The N-terminal cytoplasmic domain of MSR plays a crucial role in its internalization and surface expression, and its structure was studied using a peptide architecture technique.
- The study identified several binding proteins, including HSP90, HSP70, LAP, adenocylhomocysteinase, and GAPDH, which may influence MSR's functions related to internalization and signaling.