Publications by authors named "Junichi Ayabe"
Background: The clinical benefits of faster recanalization in acute large vessel occlusion are well recognized, but the optimal procedure time remains uncertain. The aim of this study was to identify patient characteristics that necessitate puncture-to-recanalization (P-R) time within 30 min to achieve favorable outcome.
Methods: We evaluated the patients from a prospective, multicenter, observational registry of acute ischemic stroke patients.
Endovascular therapy (EVT) for real-world patients after extended time frames is associated with concerns about its efficacy and safety. We conducted a prospective registry at 77 centers between November 2019 and October 2020. The registry criteria included patients treated with Trevo Retriever alone or in combined therapy with an aspiration catheter.
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- The 2021 WHO classification of CNS tumors combines histopathology and molecular profiling to effectively differentiate between adult malignant brain tumors, particularly gliomas and primary CNS lymphomas (PCNSL).
- A new intraoperative integrated diagnostic (i-ID) system has been developed that enhances traditional frozen-section diagnosis with a qPCR-based genotyping assay, crucial for therapeutic decision-making.
- After testing the i-ID system on 101 patients, it showed high reliability, matching permanent diagnoses in nearly all cases, thus proving to be a valuable tool for accurate classification of adult malignant CNS tumors.
Article Synopsis
- The study investigated the impact of treatment timing (on-duty vs. off-duty hours) on outcomes for patients undergoing endovascular treatment for acute ischemic stroke.
- It analyzed data from 1,571 patients in a multicenter registry, focusing on the modified Rankin Scale (mRS) at 90 days post-stroke as the primary outcome measure.
- Results indicated no significant difference in mRS scores between on-duty and off-duty patients, but off-duty patients experienced longer door-to-puncture times, leading to poorer outcomes when that time exceeded 60 minutes, influenced by factors like low NIHSS scores and diabetes.
Article Synopsis
- This study evaluated how effective and safe thrombectomy is for acute ischaemic stroke patients who had some pre-stroke disability, using data from 2313 patients.
- Out of the 2136 patients analyzed, 33.3% with pre-stroke disabilities achieved a favorable outcome (mRS score of 0-3) after 90 days, with NIHSS scores being a significant predictor of success.
- The findings suggest that both intravenous t-PA and thrombectomy are safe and particularly beneficial for patients with lower NIHSS scores experiencing stroke-related disabilities.
Background: Endovascular treatment (EVT) for acute large vessel occlusion has proven to be effective in randomized controlled trials. We conducted a prospective cohort study to evaluate the real-world efficacy of EVT in a metropolitan area with a large number of comprehensive stroke centers and to compare it with the results of other registries and randomized controlled trials (RCTs).
Methods: We analyzed the Kanagawa Intravenous and Endovascular Treatment of Acute Ischemic Stroke registry, a prospective, multicenter observational study of patients treated by EVT and/or intravenous tissue-type plasminogen activator (tPA).
The causes of spinal epidural hematoma (SEH) have been attributed to coagulopathy, trauma, vascular anomalies, and so forth. The incidence of vascular anomalies shown by digital subtraction angiography has been reported to be 15%, and most cases have been reported to be spinal epidural arteriovenous fistulae. SEH has rarely been caused by venous congestion.
View Article and Find Full Text PDFObjective: Subarachnoid hemorrhage due to ruptured vertebral artery dissecting aneurysm (rVADA) is associated with a high frequency of acute rebleeding and requires early treatment following onset. Parent artery occlusion (PAO) or stent-assisted coiling (SAC) embolization is selected as a treatment option according to the individual patient condition. This report is a retrospective examination evaluating the treatment outcomes for rVADA.
View Article and Find Full Text PDFNeuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated disorder. It often develops acute myelopathy due to longitudinally extensive transverse myelitis (LETM), although other disorders can cause an LETM-like lesion. Here, we report a 76-year-old patient presenting with acute-onset, progressive myelopathy, which proved to be caused by an intracranial dural arteriovenus fistula (dAVF).
View Article and Find Full Text PDFHistologically, hepatocellular carcinoma (HCC) and atypical pituitary adenoma are similar, posing a potential clinical problem. A 76-year-old woman, whose past medical history was significant for hepatitis C virus (HCV), positivity without liver cirrhosis was presented with abducens nerve (CN VI) palsy. Contrast-enhanced magnetic resonance imaging (MRI) showed a clival tumor with infiltration of the right cavernous sinus.
View Article and Find Full Text PDFBackground: Instances of ectopic salivary gland tissue within the pituitary gland are rare, they are mostly asymptomatic, and the underlying pathophysiology of symptomatic cases is unclear. We report a case of intrasellar salivary gland rest that presented clinical symptoms and clearly related to inflammatory changes.
Case Description: In the present case, headache, bitemporal hemianopia, and hormone abnormality led to the detection of ectopic salivary gland tissue within the pituitary gland of a 24-year-old man.