Glutamate chemical exchange saturation transfer (GluCEST) MRI to evaluate the relationship between demyelination and glutamate content in depressed mice.

Glutamatergic alteration is one of the potential mechanisms of depression. However, there is no consensus on whether glutamate metabolism changes affect the myelin structure of depression in mouse models. Glutamate chemical exchange saturation transfer (GluCEST) is a novel and powerful molecular imaging technique that can visualize glutamate distribution.

Hetero Diels-Alder reactions of isolable -borylenamines.

A new strategy for -borylenamines by reaction of 2-alkynyl benzyl azides with B(CF) was developed. This novel 1,3-carboboration reaction proceeded a 5- cyclization/formal 1,1-carboboration/B(CF) shift reaction sequence. Additionally, -borylenamines can undergo hetero Diels-Alder (HDA) reactions with a variety of dienophiles.

Metal-free -hydroboration without a B-H bond: reactions of propargyl amines with Lewis acidic boranes.

The first alkyne -hydroboration reaction without a B-H bond was described. This was achieved by reactions of propargyl amines with Lewis acidic boranes under mild conditions. The mechanism involved borane-mediated alkyne activation and intramolecular hydride transfer, thus realizing a unique hydroboration in the absence of a B-H bond.