Publications by authors named "Junhui Dai"
Article Synopsis
- This study focused on identifying immune states that increase the risk of preterm birth by examining the immune characteristics and microbial profiles of pregnant women.
- Researchers used advanced methods like immunophenotyping, microbial sequencing, and statistical analysis to differentiate between immune subtypes and their relationship with preterm birth.
- The findings revealed three immune subtypes, notable differences in vaginal microbiota, and specific immune factors linked to preterm birth, suggesting intricate interactions between immune responses and microbial composition.
Background: A burgeoning body of evidence has substantiated the association between alterations in the composition of the gut microbiota and rheumatoid arthritis (RA). Nevertheless, our understanding of the intricate mechanisms underpinning this association is limited.
Methods: To investigate whether the gut microbiota influences the pathogenesis of RA through metabolism or immunity, we performed rigorous synthesis analyses using aggregated statistics from published genome-wide association studies (GWAS) using two-sample Mendelian randomization (MR) and mediated MR techniques, including two-step MR and multivariate MR analyses.