The causal association between lipid-lowering strategies and risk of intracranial aneurysms: A drug-target Mendelian randomization study.

Background: Observational studies have suggested potential correlations between unfavorable lipid profiles and the occurrence of intracranial aneurysms (IAs), proposing that lipid-lowering therapies might curb IA progression and prevent rupture. This study aimed to explore the causal impacts of lipid-reducing strategies on the risk of IAs.

Methods: We employed 3 genetic tools as proxies for our exposures and assessed causal effects using outcome genome-wide association study data from the FinnGen Biobank.

[Clinical analysis of treatment free remission outcomes after discontinuation of tyrosine kinase inhibitors in childhood chronic myeloid leukemia].

To analyze the treatment-free remission (TFR) outcomes after discontinuation of tyrosine kinase inhibitor (TKI) in children with chronic myeloid leukemia (CML). In this retrospective cohort study, clinical data of 14 chronic phase CML children aged <18 years who had achieved stable deep molecular response (DMR) for ≥ 2 years after standardized treatment with TKI and had a strong desire to discontinue TKI at Henan Cancer Hospital from September 30, 2016 to January 30, 2022 were collected retrospectively. According to the different TFR outcomes after discontinuation of TKI, patients were divided into loss of major molecular response (MMR) group and without loss of MMR group, differences in clinical characteristics between the two groups of children were analyzed using Mann-Whitney test and Fisher exact test.

Effects of transcutaneous auricular vagus nerve stimulation on postoperative delirium in older patients with hip fracture: protocol for a randomised controlled trial.

Background: Postoperative delirium (POD) is an acute neurocognitive impairment and is commonly observed in older patients with hip fractures. POD is associated with poor outcomes, including increased postoperative complications, prolonged hospitalisation, high costs and increased perioperative mortality. Therefore, reducing the occurrence of POD and improving cognitive abilities in older patients are critical and urgent.

Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis.

Human rhinovirus (HRV) causes the common cold and exacerbates chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease. Despite its significant impact on public health, there are currently no approved vaccines or antiviral treatments for HRV infection. Apoptosis is the process through which cells eliminate themselves through the systematic activation of intrinsic death pathways in response to various stimuli.

Prenatal diagnosis and pregnancy outcomes in fetuses with vertebral abnormalities.

Objective: To investigate the genetic risk and pregnancy outcomes of fetuses who had the sonographic diagnosis of vertebral abnormalities (VA).

Methods: Fifty-two fetuses with sonographically detected VA (excluding neural tube defects) were included in the study. Data on prenatal ultrasound scan, prenatal genetic testing by amniocentesis, and pregnancy outcomes were collected and reviewed.

Bioadhesive levan-based coaxial nanofibrous membranes with enhanced cell adhesion and mesenchymal stem cell differentiation.

Conventional electrospun nanofibrous membranes have been widely used for tissue engineering scaffolds because they can mimic extracellular matrix (ECM), which plays a significant role in cell proliferation, adhesion, and differentiation. However, the inadequate mechanical strength and biological functions of electrospun nanofibrous scaffolds limit the range of their practical applications. In this study, we prepared a uniform levan-based core-shell composite (csCAL) nanofibrous membrane using the coaxial electrospinning technique.

Dextran from human feces-derived Weissella cibaria facilitates intestinal mucosal barrier function by modulating gut bacteria and propionate levels.

The disruption of the intestinal mucosal barrier is strongly associated with the onset of various diseases, including inflammatory bowel disease. Exopolysaccharides (EPS) support the functionality of the intestinal barrier. Weissella Cibaria (W.

Clinical outcomes after stenting treatment in patients with idiopathic intracranial hypertension and intrinsic versus extrinsic venous sinus stenosis.

Background: Endovascular stenting is a promising treatment for patients with idiopathic intracranial hypertension (IIH) and venous sinus stenosis (VSS). However, data on the impact of stenosis type on clinical outcomes of patients undergoing stenting treatment remain limited. This prospective cohort study aimed to compare post-stenting outcomes in patients with IIH and intrinsic versus extrinsic VSS.

Exploring Insecticidal Molecules with Random Forest: Toward High Insecticidal Activity and Low Bee Toxicity.

Insecticidal molecules with high activity are crucial for global pesticide reduction and food security. However, their usage is limited by their concomitant high toxicity to bees. Balancing insecticidal activity and bee toxicity remains a critical challenge in the exploitation of new insecticidal molecules.

A New Triangular Muscle Flap Esophagogastrostomy After Proximal Gastrectomy.

Background: Standardized proximal gastrectomy for upper-third gastric cancer (UGC) is lacking due to the current methods' inability to prevent reflux and facilitate postoperative endoscopic monitoring surveillance. In this study, we provide a detailed description of proximal gastrectomy utilizing a new triangular muscle flap for esophagogastrostomy and evaluate the postoperative outcomes of this technique.

Method: A total of 17 patients diagnosed with early-stage primary UGC underwent laparoscopic proximal gastrectomy between May 2021 and May 2022.

Plant-derived extracellular vesicles as nanocarriers for combination therapy enhancing paclitaxel-based regimens in breast cancer.

Breast cancer remains a leading cause of morbidity and mortality worldwide. Triple-negative breast cancer (TNBC) presents unique challenges owing to its aggressiveness and limited treatment options. Paclitaxel-based chemotherapy is widely used in breast cancer treatment.

Non-van-der-Waals Oriented Two-Dimensional UiO-66 Films by Rapid Aqueous Synthesis at Room Temperature.

The synthesis of MOFs in a two-dimensional (2D) film morphology is attractive for several applications including molecular and ionic separation. However, 2D MOFs have only been reported from structures that crystallize in lamellar morphology, where layers are held together by van der Waals (vdW) interaction. By comparison, UiO-66, one of the most studied MOFs because of its exceptional chemical stability, has only been reported in three-dimensional (3D) morphology.

TRIM22 inhibits the metastasis of colorectal cancer through facilitating β-Catenin degradation.

Tripartite motif-containing 22 (TRIM22), a member of the tripartite motif protein family, has emerged as a putative tumor suppressor in various cancers. Nevertheless, its specific role and clinical significance in colorectal cancer (CRC) remain poorly characterized. Herein, we observed that TRIM22 expression was frequently downregulated in primary CRC tissues and was significantly correlated with better prognosis.

MitoQ alleviates HO-induced mitochondrial dysfunction in keratinocytes through the Nrf2/PINK1 pathway.

Oxidative stress plays a critical role in the pathogenesis of vitiligo by damaging keratinocytes, which disrupts their biological functions and influences the progression of the disease. MitoQ, a mitochondria-specific antioxidant, has the potential to prevent disorders associated with oxidative stress and to exert protective effects specifically on mitochondria. This study investigated the protective effects of MitoQ against oxidative stress in keratinocytes.

Advances in Palmitoylation: A key Regulator of liver cancer development and therapeutic targets.

Liver cancer ranks as the second leading cause of cancer-related deaths globally, which remains a significant public health concern. The development of liver cancer is associated with several signaling pathways, particularly metabolic reprogramming. Protein S-palmitoylation, a type of lipid post-translational modification (PTM), involves the reversible attachment of palmitic acid to a cysteine residue through a thioester bond.

Association between long-term PM exposure and risk of infectious diseases - acute otitis media, sinusitis, pharyngitis, and tonsillitis in children: A nationwide longitudinal cohort study.

Background: Air pollution, particularly particulate matter, has been linked to various health issues, including respiratory infections in children. This study investigates the impact of long-term PM2.5 exposure on acute otitis media (AOM), sinusitis, pharyngitis, and tonsillitis in a large Korean cohort.

Comprehensive multi-omics analyses exposes a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition.

Introduction: Hepatocellular carcinoma (HCC) is an extremely heterogeneous malignancy with a poor prognosis, highlighting the need to target specific vulnerabilities within the tumor during treatment.

Objectives: This study employs multi-omics analysis techniques to provide novel insights into personalized therapeutic strategies for HCC patients.

Methods: We performed proteomic and transcriptomic sequencing on 178 and 94 clinical samples of primary HCC without prior treatment, respectively.

Association of thallium exposure in early life with gut microbiota in neonates.

Previous research has found a correlation between heavy metals and gut microbiota in humans. However, there are few population-based studies examining the impact of early life thallium (Tl) exposure on neonatal microbiome. 342 newborns were recruited from Hunan Children's Hospital and subsequently divided into three groups (low, medium, and high) based on the 25th and 75th percentiles of serum Tl concentration.

A multifunctional hydrogel of cellulose nanofiber/microfibrillated cellulose hierarchical network for photothermal antibacterial and all-solid supercapacitor assembly.

In recent years, flexible-hydrogel wearable devices have undergone rapid development while photothermal therapy, energy storage/conversion, and other fields have been widely developed and used. However, the poor mechanical properties of hydrogels can affect their stability and reliability in practical applications, and it is often difficult to achieve both excellent mechanical properties and multifunctional characteristics. This study prepared a hierarchical cellulose network/PVA multifunctional composite hydrogel (MCPH) using cellulose nanofiber as fine fibers and microfibrillated cellulose as coarse fibers.

Predicting Treatment Response of rTMS in Major Depressive Disorder Using a Explainable Machine Learning Model Based on EEG and Clinical Features.

Objective: Major Depressive Disorder (MDD) is highly heterogeneous in response to rTMS, and identifying predictive biomarkers is essential for personalized treatment. However, current researches either only uses EEG or clinical features, lacks interpretability, or have small sample sizes.

Method: This study included 74 MDD patients who responded (Responder) and 43 MDD who did not respond (NonResponder) to rTMS.

Mechanism of action of Danlou tablets affecting MAFLD via KEAP1-mediated oxeiptosis.

Ethnopharmacological Relevance: Metabolic fatty liver disease (MAFLD) is a significant risk factor for atherosclerotic cardiovascular disease. Several preliminary studies on MAFLD animal models have indicated the therapeutic potential of Danlou tablets (DLT), a primary Chinese medicine used for managing coronary artery disease. However, the underlying mechanism of DLT in the treatment of MAFLD remains elusive.

SecY translocon chaperones protein folding during membrane protein insertion.

The Sec translocon is vital for guiding membrane protein insertion into lipid bilayers. The insertion and folding processes of membrane proteins are poorly understood. Here, we report cryo-electron microscopy structures of multi-spanning membrane proteins inserting through the SecY channel, the Sec translocon in prokaryotes.

Quadratic associations between sleep and multimorbidity among the older population in China: Evidence from CLHLS 2011 to 2018.

Objectives: To investigate the relationship between sleep and multimorbidity, including the associations between sleep duration and multimorbidity, as well as between sleep quality and multimorbidity.

Methods: Using data from the three latest waves of the Chinese Longitudinal Health Longevity Study (2011, 2014, and 2018), a binary panel regression was conducted to investigate the quadratic relationship between sleep duration and multimorbidity. Subsequently, quadratic fitting and robustness analysis were further utilized to strengthen the verification of this relationship.

A semi-parameter copula model for vehicle damage severity in lane-changing related crashes.

Lane changing behaviour occurs frequently on the highways. However, it also poses a major impact on traffic operation and safety since complex interactions between two or more vehicles on different traffic lanes are involved. In the lane-changing related crashes, correlation in damage level among the vehicles involved is prevalent.

Classification and predictive leaching risk assessment of construction and demolition waste using multivariate statistical and machine learning analyses.

Managing construction and demolition waste (CDW) poses serious concerns regarding landfilling and recycling because of the potential release of hazardous elements after leaching. Ceramic materials such as bricks, tiles, and porcelain account for more than 70% of CDW. Fourteen samples of different CDW products from Ferrara (Northeast Italy) were subjected to geochemical analyses, including leaching tests, in accordance with UNI EN 12457-2.