Ruxolitinib enhances gastric cancer to chemotherapy by suppressing JAK/STAT3 and inducing mitochondrial dysfunction and oxidative stress.

Objective: Chemoresistance in gastric cancer poses a major challenge in treatment, necessitating the development of novel therapeutic strategies. This study evaluates the efficacy of ruxolitinib, a JAK1/2 inhibitor, in both sensitive and resistant gastric cancer cell lines.

Materials And Methods: Gastric cancer cell lines, including sensitive (N87 and AGS) and resistant (N87-R and AGS-R) variants, were treated with ruxolitinib alone or in combination with chemotherapeutic agents.

Stroke Diagnosis and Prediction Tool Using ChatGLM: Development and Validation Study.

Background: Stroke is a globally prevalent disease that imposes a significant burden on health care systems and national economies. Accurate and rapid stroke diagnosis can substantially increase reperfusion rates, mitigate disability, and reduce mortality. However, there are considerable discrepancies in the diagnosis and treatment of acute stroke.

Research on the Mechanism of Hydrogen Peroxide Synthesis from Oxygen and Water on a Boron Nitride Surface at Room Temperature.

At ambient conditions, boron nitride (BN) is incapable of catalyzing the liquid-phase synthesis of hydrogen peroxide from oxygen and water. However, experiments have demonstrated that friction can significantly enhance the efficiency of this reaction. Under certain experimental conditions, the yield of hydrogen peroxide reached 8374.

Modulating Coordination Environment of Single Nickel Atom in Covalent Organic Framework to Enhance Photocatalytic Hydrogen Evolution Reaction.

Covalent organic frameworks (COFs) have emerged as fascinating platforms for photocatalytic hydrogen evolution reactions in recent years. However, the relationship between the coordination environment of metals in a covalent organic framework and catalytic properties is still rarely studied. In this study, a covalent organic framework (COF-BP), containing a benzothiazole unit with typical electron-withdrawing properties, was successfully synthesized from 4,4'-(benzo-2,1,3-thiadiazole-4,7-diyl)dianiline and 3,3',5,5'-tetraformyl-4,4'-biphenyldiol.

Association Between Dietary Inflammatory Potential and Liver Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis.

Objective: To investigate the dose-response association between dietary inflammatory potential and the risk of liver cancer.

Methods: A systematic search was conducted across Medline (National Library of Medicine using PubMed as the search engine) and Web of Science and Embase databases published until January 9, 2024. Dietary inflammatory potential was expressed using a combination of dietary inflammatory index (DII) and empirical dietary inflammatory pattern (EDIP).

In Situ NADH-Activated BODIPY-Based Macrocyclic Supramolecular Photosensitizer for Chemo-Photodynamic Synergistic Tumor Therapy.

Photodynamic therapy (PDT) based on supramolecular assembly has been receiving wide attention due to its great potential application in clinical treatment. Herein, we report a supramolecular photoelectron "reservoir" (SPR) constructed by tetracationic boron dipyrromethene (BODIPY)-based macrocycle (4Cl), doxorubicin (Dox), and tumor-targeted β-cyclodextrin-grafted hyaluronic acid (HACD). Upon irradiation, 4Cl can in situ catalyze nicotinamide adenine dinucleotide (NADH) to continuously generate electrons to inject into SPR, which further transfers electrons to oxygen, inducing highly efficient hydroxyl radical generation even under hypoxia.

Incorporation of Triacylglycerol and Cholesteryl Ester Droplets in Phase-Separated Giant Unilamellar Vesicles.

Cytoplasmic lipid droplets form from the endoplasmic reticulum (ER). Because the ER membrane can undergo phase separation, the interaction of lipid droplets with phase-separated bilayers is of significant interest. In this study, we used fluorescence microscopy to investigate the incorporation of droplets composed of triolein, trilinolein, trimyristolein, trieicosenoin, and cholesteryl arachidonate in the bilayers of giant unilamellar vesicles (GUVs) consisting of a mixture of 1,2-dioleoyl--glycero-3-phosphocholine (DOPC), 1,2-dipalmitoyl--glycero-3-phosphocholine (DPPC), and cholesterol.

Bone marrow transplant protects mice from sickle cell-mediated large artery remodeling.

Sickle cell disease (SCD) is a hereditary blood disorder that causes sickling of red blood cells under deoxygenation, which stiffens and damages the cells. Individuals homozygous for the mutant β-globin S allele (SS) endure complications including progressive arterial damage and heightened risk of stroke. The effectiveness of bone marrow transplantation (BMT), now the only curative treatment for SCD, in halting or reversing SCD-mediated arteriopathy remains unclear.

Repression of the ERRγ-CYP2E1 pathway by fibroblast growth factor 4 mitigates alcoholic liver injury.

Background And Aims: Alcoholic liver disease (ALD) represents a critical global health challenge characterized by liver damage resulting from excessive alcohol consumption. Early detection and timely intervention are essential for optimizing patient outcomes. However, the mechanisms underlying alcohol-induced liver injury have not been fully elucidated.

High Current and Carrier Densities in 2D MoS/AlScN Field-Effect Transistors via Ferroelectric Gating and Ohmic Contacts.

Ferroelectric field-effect transistors (FeFET) with two-dimensional (2D) semiconductor channels are promising low-power, embedded nonvolatile memory (NVM) candidates for next-generation in-memory computing. However, the performance of FeFETs can be limited by a charge imbalance between the ferroelectric layer and the channel and, for low-dimensional semiconductors, also by a high contact resistance between the metal electrodes and the channel. Here, we report a significant enhancement in performance of contact-engineered FeFETs with a 2D MoS channel and a ferroelectric AlScN (AlScN) gate dielectric.

An Engineered Heterostructured Trinity Enables Fire-Safe, Thermally Conductive Polymer Nanocomposite Films with Low Dielectric Loss.

To adapt to the trend of increasing miniaturization and high integration of microelectronic equipments, there is a high demand for multifunctional thermally conductive (TC) polymeric films combining excellent flame retardancy and low dielectric constant (ε). To date, there have been few successes that achieve such a performance portfolio in polymer films due to their different and even mutually exclusive governing mechanisms. Herein, we propose a trinity strategy for creating a rationally engineered heterostructure nanoadditive (FG@CuP@ZTC) by in situ self-assembly immobilization of copper-phenyl phosphonate (CuP) and zinc-3, 5-diamino-1,2,4-triazole complex (ZTC) onto the fluorinated graphene (FG) surface.

The role of different physical exercises as an anti-aging factor in different stem cells.

The senescence process is connected to the characteristics of cellular aging. Understanding their causal network helps develop a framework for creating new treatments to slow down the senescence process. A growing body of research indicates that aging may adversely affect stem cells (SCs).

Fabrication and application of continuous douche for Da Vinci surgical robot arm.

Background: The use of robotic surgery in hospitals is becoming increasingly widespread.

Objective: This research was performed to design a continuous douche for surgical robotic arm operated instruments and evaluate its use.

Methods: A continuous irrigator was designed for robotic arm operated surgical instruments.

Sequential combined bypassing therapy in haemophilia patients with high titer inhibitors: surgical experience.

Sequential combination bypass therapy (SCBT) is an effective treatment option for haemophilia patients with inhibitors; however, its safety, efficacy, and cost have largely have yet to be systematically evaluated. To address this question, we retrospectively analyzed the medical records of 14 haemophilia patients with high titer inhibitors who underwent surgery. The patients with high inhibitors were treated with two SCBT regimens by optimizing doses of the recombinant activated factor VII (rFVIIa) and prothrombin complex concentrate (PCC).

An elevated triglyceride-glucose index in the first-trimester predicts adverse pregnancy outcomes: a retrospective cohort study.

Background: The relationship of the first-trimester triglyceride-glucose (TyG) index with GDM (gestational diabetes mellitus) and other adverse pregnancy outcomes has yet to be fully understood. This study aims to investigate the relationship between the first-trimester TyG index and the risk of adverse pregnancy outcomes in pregnant women.

Methods: The data for the retrospective cohort study were derived from the Maternal and Child Health Hospital of Longgang District, Shenzhen, China.

A deep learning-based psi CT network effectively predicts early recurrence after hepatectomy in HCC patients.

Background: Hepatocellular carcinoma (HCC) exhibits a high recurrence rate, and early recurrence significantly jeopardizes patient prognosis, necessitating reliable methods for early recurrence prediction.

Methods: Utilizing multi-institutional data and integrating deep learning (DL) techniques, we established a neural network based on DenseNet capable of concurrently processing patients' triphasic enhanced CT scans. By incorporating an attention mechanism, the model automatically focuses on regions that significantly impact patient survival.

Air-Stable Mid-Infrared Sensitive Cation-Exchanged Silver-Doped Mercury Telluride Nanocrystal.

We present an air-stable mid-infrared (mid-IR) Ag-doped HgTe (Ag-HgTe) colloidal quantum dots (CQDs) synthesized by a newly developed cation-exchange (CE) method in solution phase and mid-IR diode sensors fabricated with the as-synthesized Ag-HgTe quantum dots (QDs). The cation-exchanged p-doped Ag-HgTe CQDs are used for the p-n junction formation with a n-doped HgTe CQDs. Surprisingly, the Ag-HgTe CQDs sustain the optical and physical properties in the colloidal phase under ambient conditions for 900 days.

IL-8-NF-κB-ALDH1A1 loop promotes the progression of intrahepatic cholangiocarcinoma.

Background: Intrahepatic cholangiocarcinoma (ICC) is a poor prognosis of malignant cancer with high lymph node metastasis and resistance to systemic therapies. Recent studies suggested that the involvement of IL-8 could promote ICC metastasis through epithelial-mesenchymal transition while the ICC-ALDH1A1high subtype is clarified by multi-omics study. The correlation between ALDH1A1 and IL-8 in ICC remains elusive.

Seneca Valley virus infection exploits DNA damage response to facilitate viral replication.

Seneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry. DNA and RNA viruses manipulate the host DNA damage response (DDR) to modulate cellular machinery and facilitate their life cycles. However, the interaction between the host DDR and SVV infection remains unexplored.

Design, Synthesis, and Structure-Activity Relationship of 2-(Piperazin-1-yl)quinazolin-4(3)-one Derivatives as Active Agents against .

A novel series of quinazolin-4(3)-one derivatives were synthesized using a hybridization strategy that combined the quinazolin-4(3)-one scaffold, the diarylether fragment, and the piperazine ring. The activity evaluation of these compounds against demonstrated that most of this series of compounds showed moderate to good effectiveness, with IC values ranging from 5.94 to 102.

Dian sanguis draconis improves pulmonary fibrosis by activating autophagy to regulate the PA/PAI-1 balance.

Background: Pulmonary fibrosis (PF) is a severe lung disease that manifests as lung tissue destruction and collagen deposition and easily leads to respiratory failure. It is difficult to reverse these conditions using current treatment methods. This study focused on the exploration and development of novel drugs for the treatment of PF.

Role of Cardiovascular Health in the Bidirectional Progression Trajectories Between Cardiovascular Disease, Type 2 Diabetes, and Cancer.

Background: There existed bidirectional associations of cardiovascular disease (CVD) and type 2 diabetes (T2D) with cancer, partly attributed to their shared risk factors. We aimed to explore the role of cardiovascular health (CVH) in bidirectional transitions between CVD, T2D, and cancer.

Methods: Based on the UK Biobank, we used 2 subcohorts: a disease-free cohort of 277 997 individuals without cancer, CVD, and T2D; and a disease survivor cohort consisting of 61 971 cases with cancer, CVD, and T2D at baseline.

Nanoconfinement-Induced Electrochemical Ion-Solvent Cointercalation in Pillared Titanate Host Materials.

Electrochemical ion-solvent cointercalation reactions are an avenue to reach improved kinetics compared to the corresponding intercalation of desolvated ions. Here, we demonstrate the impact of different structural pillar molecules on the electrochemical Li intercalation mechanism in expanded hydrogen titanate (HTO) electrode materials. We show that interlayer-expansion of HTO with organic pillars can enable cointercalation reactions.