Magnetically targeted delivery of probiotics for controlled residence and accumulation in the intestine.

The effectiveness of orally delivered probiotics in treating gastrointestinal diseases is restricted by inadequate gut retention. In this study, we present a magnetically controlled strategy for probiotic delivery, which enables controlled accumulation and residence of probiotics in the intestine. The magnetically controlled probiotic is established by attaching amino-modified iron oxide (FeO-NH NPs) to polydopamine-coated GG (LGG@P) through electrostatic self-assembly and named as LGG@P@FeO.

Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis.

Osteoarthritis (OA) is the most common musculoskeletal disease globally and is the main reason for the chronic pain and disability in people over sixty-five worldwide. Degradation of the articular cartilage, synovial inflammation and osteophyte formation are widely acknowledged as the primary pathological manifestations of OA. OA affects more than 300 million people all over the world, bringing extremely large socioeconomic burden.

Effects of faecal microbiota transplantation supplemented with inulin on early immunity and immune organ histomorphology in chickens.

1. Faecal microbiota transplantation (FMT) is a technique that promotes gut microbiota diversity and abundance by transplantation of faeces into a recipient's gastrointestinal tract multiple routes.2.

A Novel Coating-Extrusion Method Enabled, High Energy, Power Density, and Scalable Production in Monolithically Integrated Energy Storage Fibers.

The rise of wearable electronics demands flexible energy storage solutions like flexible fiber energy storage devices (FESDs), known for their flexibility and portability. However, it remains difficult for existing fabrication methods (typically, finite-coating, thermal-drawing, and solution-extrusion) to simultaneously achieve desirable electrochemical performances and fast production of FESDs. Here, a new scalable coating-extrusion method is developed, utilizing a novel extruded spinneret with tapered apertures to create dual pressure zones.

Unlocking the Potential of Machine Learning in Co-crystal Prediction by a Novel Approach Integrating Molecular Thermodynamics.

Co-crystal engineering is of interest for many applications in pharmaceutical, chemistry and material fields, but rational design of co-crystals is still challenging. Although artificial intelligence has brought major changes in the decision-making process for materials design, yet limitations in generalization and mechanistic understanding remain. Herein, we sought to improve prediction of co-crystal by combining mechanistic thermodynamic modeling with machine learning.

Phase and Orbital Engineering Effectuating Efficient Adsorption and Catalysis toward High-Energy Lithium-Sulfur Batteries.

The delicate construction of electrocatalysts with high catalytic activity is a strategic method to enhance the kinetics of lithium-sulfur batteries (LSBs). Adjusting the local structure of the catalyst is always crucial for understanding the structure-activity relationship between atomic structure and catalyst performance. Here, in situ induction of electron-deficient B enables phase engineering MoC, realizing the transition from hexagonal (h-MoC) to cubic phase (c-B-MoC).

Kinetic Energy Measured by 4D Flow Cardiac MRI in Evaluating Intraventricular Hemodynamics: A Systematic Review.

Unlabelled: Four-dimensional flow cardiovascular magnetic resonance (4D Flow cardiac MRI) is an advanced non-invasive imaging technology, and its derived kinetic energy (KE) blood flow parameters have been confirmed as a potential biomarkers for assessing ventricular hemodynamics. This review synthesizes details on the methodology, clinical significance, and current status of studies focused on quantifying KE parameters of the ventricle using 4D Flow cardiac MRI, providing an objective foundation for further exploration of the value of KE in cardiac diseases.

Study Type: retrospective.

Photocatalytic Degradation of Ciprofloxacin by GO/ZnO/Ag Composite Materials.

This study synthesized graphene oxide (GO)/zinc oxide (ZnO)/silver (Ag) composite materials and investigated their photocatalytic degradation performance for ciprofloxacin (CIP) under visible light irradiation. GO/ZnO/Ag composites with different ratios were prepared via an impregnation and chemical reduction method and characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). The results demonstrated that under optimal conditions (20 mg/L CIP concentration, 15 mg catalyst dosage, GO/ZnO-3%/Ag-doping ratio, and pH 5), the GO/ZnO/Ag composite exhibited the highest photocatalytic activity, achieving a maximum degradation rate of 82.

The Effect of Deep Cryogenic Treatment on the Electrocatalytic Performance of a Pd@CFs Catalyst for Methanol Oxidation.

To enhance the electrocatalytic performance of a flexible Pd@CFs catalyst for methanol oxidation, deep cryogenic treatment in liquid nitrogen was introduced. The effects of the frequency and time of the deep cryogenic treatment on the surface crystal orientation, microstructure morphology, mechanical performance, and electrocatalytic performance for methanol oxidation were studied. The results showed that when the frequency of the deep cryogenic treatment was 2 times and the deep cryogenic time was 24 h, the electrocatalytic performance of the catalyst was the best.

Diabetic Retinopathy (DR): Mechanisms, Current Therapies, and Emerging Strategies.

Diabetic retinopathy (DR) is one of the most prevalent complications of diabetes, affecting nearly one-third of patients with diabetes mellitus and remaining a leading cause of blindness worldwide. Among the various diabetes-induced complications, DR is of particular importance due to its direct impact on vision and the irreversible damage to the retina. DR is characterized by multiple pathological processes, primarily a hyperglycemia-induced inflammatory response and oxidative stress.

THz Waves Improve Spatial Working Memory by Increasing the Activity of Glutamatergic Neurons in Mice.

Terahertz (THz) waves, a novel type of radiation with quantum and electronic properties, have attracted increasing attention for their effects on the nervous system. Spatial working memory, a critical component of higher cognitive function, is coordinated by brain regions such as the infralimbic cortex (IL) region of the medial prefrontal cortex and the ventral cornu ammonis 1 (vCA1) of hippocampus. However, the regulatory effects of THz waves on spatial working memory and the underlying mechanisms remain unclear.

Mechanical forces and enzymatic digestion act together to induce the remodeling of collagen fibrils in tumor microenvironment.

Cancer is a serious disease in human beings, and its high lethality is mainly due to the invasion and metastasis of cancer cells. Clinically, the accumulation and high orientation of collagen fibrils were observed in cancerous tissue, which occurred not only at the location of invasion but also at 10-20 cm from the tumor. Studies indicated that the invasion of cancer cells could be guided by the oriented collagen fibrils, even in a dense matrix characterized by difficulty degradation.

Fluor-Predictor: An Interpretable Tool for Multiproperty Prediction and Retrieval of Fluorescent Dyes.

With the rapid advancements in the field of fluorescent dyes, accurate prediction of optical properties and efficient retrieval of dye-related data are essential for effective dye design. However, there is a lack of tools for comprehensive data integration and convenient data retrieval. Moreover, existing prediction models mainly focus on a single property of fluorescent dyes and fail to account for the diverse fluorophores and solutions in a systematic manner.

Efficient Metabolomics Profiling from Plasma Extracellular Vesicles Enables Accurate Diagnosis of Early Gastric Cancer.

Accurate diagnosis of early gastric cancer is valuable for asymptomatic populations, while current endoscopic examination combined with pathological tissue biopsy often encounters bottlenecks for early-stage cancer and causes pain to patients. Liquid biopsy shows promise for noninvasive diagnosis of early gastric cancer; however, it remains a challenge to achieve accurate diagnosis due to the lack of highly sensitive and specific biomarkers. Herein, we propose a protocol combining metabolomics profiling from plasma extracellular vesicles (EVs) and machine learning to identify the metabolomics discrepancies of early gastric cancer individuals from other populations.

Isoguanosine-Induced ER Stress via AMPK Enhances Chemosensitivity in OSCC.

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck; however, the efficacy of existing treatment is limited and new effective strategies need to be explored. Our previous work demonstrates that isoguanosine (isoG) is a promising nucleoside molecule with superior self-assembly capability and significant anti-OSCC potential. However, the antitumor mechanism of isoG remains unclear.

Baicalein as a potent antifungal agent against : synergy with fluconazole and sustainable production through probiotic-mediated bioconversion.

Fungal infections, particularly those caused by , represent a significant global health concern, with drug resistance and biofilm formation posing considerable challenges to effective treatment. Baicalein, a flavonoid derived from baicalin found in , has demonstrated considerable antifungal efficacy. Moreover, the combination of baicalein and fluconazole demonstrated a notable synergistic effect.

The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer's disease.

Alzheimer's disease (AD) is a severe neurodegenerative disease characterized mainly by the formation of amyloid beta (Aβ) plaques and abnormal phosphorylation of tau. In recent years, an imbalance in iron homeostasis has been recognized to play a key role in the pathological process of AD. Abnormal iron accumulation can activate various kinases such as glycogen synthase kinase-3β, cyclin-dependent kinase 5, and mitogen-activated protein kinase, leading to abnormal phosphorylation of tau and amyloid precursor protein, and accelerating the formation of Aβ plaques and neurofibrillary tangles.

Prevalence of scoliosis and congenital heart disease based on school screening in Jinghong City, Yunnan Province.

Objective: To investigate the prevalence of scoliosis and congenital heart disease (CHD) in the same area and to explore the relationship between them according to a joint school screening.

Methods: All students aged 6-15 years in 20 schools in Jinghong City, Yunnan Province, China was screened for scoliosis and CHD. Scoliosis screening completed through the Adam's forward bending test with scoliometer measurement, and CHD screening completed through auscultation combined with portable echocardiography (ECHO).

Ensartinib as a neoadjuvant therapy for stage IIIA non-small cell lung cancer patients with EML4-ALK fusion: a case report and literature review.

Anaplastic lymphoma kinase (ALK) inhibitors have shown efficacy in treating ALK-positive advanced non-small cell lung cancer (NSCLC) patients. However, the effectiveness of ensartinib neoadjuvant therapy remains ambiguous. Herein, we reported that preoperative systemic treatment with the ALK inhibitor ensartinib can be beneficial for treating initially inoperable tumors.

Young adult partner phubbing and relationship satisfaction: the mediating role of attachment anxiety and the moderating role of constructive conflict coping style.

Introduction: This study investigates the association between young adult partner phubbing and relationship satisfaction, with a focus on the mediating role of attachment anxiety and the moderating role of constructive conflict coping styles (voice or loyalty). Understanding these dynamics is crucial for enhancing relationship satisfaction among young adults.

Methods: A sample of 837 undergraduate students (376 male students; average age 21.

Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats.

Background: Patients with neuropathic pain (NP), caused by injury or disease of the somatosensory nervous system, usually suffer from severe pain. Our previous studies revealed that electroacupuncture (EA) stimulation could effectively improve NP. However, the underlying mechanisms of EA have not been fully clarified.

A bibliometric analysis of perioperative rehabilitation research between 2005 and 2024.

Effective rehabilitation can improve the prognosis of surgical patients, thereby enhancing their medical experience. In recent years, relatively more research is been carried out in this field; therefore, it is necessary to use bibliometric analysis to understand the development status and main research hotspots of perioperative rehabilitation, so as to determine the role of rehabilitation in the perioperative period. All documents related to perioperative rehabilitation and published from 2005 to 2024 were retrieved from the Web of Science Core Collection (Woscc).

Dynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine.

Objective: Both B-cell- and T-cell-mediated immunity are crucial for the effective clearance of viral infection, but little is known about the dynamic characteristics of SARS-CoV-2-specific B-cell and T-cell responses in people living with HIV (PLWH) after a full course of inactivated SARS-CoV-2 vaccination.

Methods: In this study, fifty people living with HIV (PLWH) and thirty healthy controls (HCs) were enrolled to assess B-cell and T-cell responses at the day before the vaccination (T0), two weeks after the first dose (T1), two months after the first dose (T2), the day of the third dose (T3), one month after the third dose (T4), three months after the third dose (T5) and 12 months (T6) after the third dose.

Results: SARS-CoV-2-specific B-cell and T-cell responses were induced in people living with HIV (PLWH), and these responses lasted at least one year after the third vaccine dose.

Investigating the psychophysiological effects of NaiKan Therapy: salivary oxytocin and cortisol release.

NaiKan Therapy, a method of self-reflection and introspection, has garnered considerable interest for its psychological benefits. However, its physiological impacts, particularly on hormonal regulation, remain underexplored. In this study, we aimed to investigate the effects of NaiKan Therapy on salivary oxytocin and cortisol release, shedding light on the psychophysiological mechanisms underlying this introspective practice.

Effects of circulating RNAs on tumor metabolism in lung cancer (Review).

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis and abnormal lipid and amino acid metabolism to obtain energy and nutrients for growth, proliferation and drug resistance. Circular RNAs (circRNAs), a class of non-coding RNAs, serve important biological roles in the growth and development of tumors.