Role of CD38 in mediating the effect of Bacillus on acute pancreatitis: a study of mediated Mendelian randomization.

Background: Some studies suggest a potential link between intestinal flora and acute pancreatitis (AP). However, the causal relationships between specific intestinal flora and AP, and the possible mediating role of immune cell traits, remain unclear.

Methods: A genome-wide association study (GWAS) involving 5,959 participants was conducted to identify genetic instrumental variables associated with 473 intestinal flora taxa.

Peroxynitrite scavenger FeTPPS binds with hCT to effectively inhibit its amyloid aggregation.

Human calcitonin (hCT) is an endogenous polypeptide commonly employed in treating bone resorption-related illnesses, but its clinical application is limited due to its high aggregation tendency. Metalloporphyrins are effective in suppressing amyloid fibrillation, positioning them as potential drug candidates for amyloidogenic disorders like Alzheimer's and type 2 diabetes. In this work, we investigated the effects of Fe(III) -tetra(4-sulfonatophenyl)porphine chloride (FeTPPS), a highly efficient ONOO decomposition catalyst, on hCT aggregation.

Prototype-Guided Graph Reasoning Network for Few-Shot Medical Image Segmentation.

Few-shot semantic segmentation (FSS) is of tremendous potential for data-scarce scenarios, particularly in medical segmentation tasks with merely a few labeled data. Most of the existing FSS methods typically distinguish query objects with the guidance of support prototypes. However, the variances in appearance and scale between support and query objects from the same anatomical class are often exceedingly considerable in practical clinical scenarios, thus resulting in undesirable query segmentation masks.

Gut microbiota and serum metabolome reveal the mechanism by which TCM polysaccharides alleviate salpingitis in laying hens challenged by bacteria.

This paper aimed to evaluate the effect of 3 kinds of TCM polysaccharides instead of antibiotics in preventing salpingitis in laying hens. After feeding the laying hens with Lotus leaf polysaccharide, Poria polysaccharide, and Epimedium polysaccharide, mixed bacteria (E. coli and Staphylococcus aureus) were used to infect the oviduct to establish an inflammation model.

Comparison of safety and effectiveness between robotic and laparoscopic major hepatectomy: a systematic review and meta-analysis.

Background: Robotic platform has been increasingly applied in major hepatectomy. However, the role or advantage of robotic approach comparing with laparoscopic approach in major hepatectomy remains controversial. This meta-analysis compares perioperative outcomes of robotic major hepatectomy (RMH) to laparoscopic major hepatectomy (LMH) for hepatic neoplasms.

Identification of a cuproptosis and copper metabolism gene-related lncRNAs prognostic signature associated with clinical and immunological characteristics of hepatocellular carcinoma.

Background: The relationship between cuproptosis and HCC is still in the exploratory stage. Long noncoding RNAs (lncRNAs) have recently been linked to the progression of hepatocellular carcinoma (HCC). However, the clinical significance of lncRNAs associated with cuproptosis remains unclear.

A rare case with multiple arterial variations of the liver complicated laparoscopic pancreaticoduodenectomy.

Background: Hepatic arterial variations were fully elaborated in anatomical monographs. Here, we aimed to present a rare case with multiple arterial variations of the liver complicated laparoscopic pancreaticoduodenectomy.

Case Presentation: We report a 67-year-old woman with a periampullary tumor underwent laparoscopic pancreaticoduodenectomy.

Influence of epileptogenic region on brain structural changes in Rolandic epilepsy.

To investigate the influence of epileptogenic cortex (Rolandic areas) with executive functions in Rolandic epilepsy using structural covariance analysis of structural magnetic resonance imaging (MRI). Structural MRI data of drug-naive patients with Rolandic epilepsy (n = 70) and typically developing children as healthy controls (n = 83) were analyzed using voxel-based morphometry. Gray matter volumes in the patients were compared with those of healthy controls, and were further correlated with epilepsy duration and cognitive score of executive function, respectively.

Anti-seizure medication correlated changes of cortical morphology in childhood epilepsy with centrotemporal spikes.

To investigate the morphological changes of cerebral cortex correlating with anti-seizure medication in Childhood Epilepsy with Centrotemporal Spikes (CECTS), and their relationships with seizure control. This study included a total of 188 children, including 62 patients with CECTS taking anti-seizure drugs, 56 patients with drug-naive, and 70 healthy controls. A portion of cases were also followed-up for longitudinal analysis.

Carbon Dots Exhibiting Concentration-Dependent Full-Visible-Spectrum Emission for Light-Emitting Diode Applications.

Carbon dots (CDs) that exhibit emission over the whole visible spectrum are desired for use in light-emitting diodes (LEDs). Here, CDs displaying tunable fluorescence over the whole visible region are synthesized. Different concentrations of CDs are uniformly dispersed in epoxy resin and coated on 405 nm LED chips to obtain monochrome blue, cyan, green, yellow, red, and deep red LEDs that yield a color gamut covering 99.