Publications by authors named "Junhao Cui"

Objective: To retrospectively analyze the clinical characteristics and independent risk factors of severe influenza combined with febrile seizures, and to provide more basis for early clinical intervention.

Methods: A total of 161 children with severe influenza were collected as study subjects and divided into convulsive (FC) group (40 cases) and non-convulsive (NFC) group (121 cases) according to whether they had febrile seizures. The demographic characteristics and clinical data of the two groups were analyzed.

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Background: The association between birth weight and childhood body mass index (BMI) and frailty has been extensively studied, but it is currently unclear whether this relationship is causal.

Methods: We utilized a two-sample Mendelian randomization (MR) methodology to investigate the causal effects of birth weight and childhood BMI on the risk of frailty. Instrumental variables ( < 5E-08) strongly associated with own birth weight ( = 298,142 infants), offspring birth weight ( = 210,267 mothers), and childhood BMI ( = 39,620) were identified from large-scale genomic data from genome-wide association studies (GWAS).

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Objective: To investigate the clinical characteristics and risk factors for pneumonia in children co-infected with influenza A virus (IAV) and Mycoplasma pneumoniae (MP).

Methods: Children who were diagnosed with IAV and MP infection between January and December, 2023 were enrolled and divided into a non-pneumonia group and a pneumonia group. Univariate analysis and logistic regression analysis were used to evaluate each index, and the risk factors for pneumonia caused by coinfection in the two groups were explored.

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This paper reports a case of influenza complicated with influenza associated encephalopathy complicated with acute pancreatitis. This kind of disease is relatively rare, we hope to draw people's attention to it in order to improve early detection and prognosis.

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Magnetic actuation has been well exploited for untethered manipulation and locomotion of small-scale robots in complex environments such as intracorporeal lumens. Most existing magnetic actuation systems employ a permanent magnet onboard the robot. However, only 2-DoF orientation of the permanent-magnet robot can be controlled since no torque can be generated about its axis of magnetic moment, which limits the dexterity of manipulation.

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Article Synopsis
  • β-sitosterol, a natural plant steroid, has anti-inflammatory and antioxidant properties and was investigated for its protective effects against cell damage caused by lipopolysaccharide (LPS) in bovine mammary epithelial cells.
  • The research found that combining LPS with β-sitosterol reduced oxidative stress and inflammation, increased anti-apoptotic proteins, and activated the HIF-1α/mTOR signaling pathway, promoting cell survival and better lipid synthesis.
  • The study suggests that β-sitosterol could be effective in reducing inflammation in the mammary gland.
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Article Synopsis
  • A series of 1,4-naphthoquinone derivatives were created and analyzed as potential anti-cancer agents, with the crystal structure of one compound confirmed through X-ray diffraction.
  • Testing on four cancer cell lines revealed that one compound displayed significant cytotoxicity specifically on the A549 cell line, with an IC value of 6.15 μM.
  • Further studies indicated that this compound induced autophagy by enhancing EGFR recycling and activating its signaling pathway, suggesting a promising approach for developing new anti-cancer drugs.
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Although conjugated linoleic acid (CLA) can promote human health, its content in milk is insufficient to have a significant impact. The majority of the CLA in milk is produced endogenously by the mammary gland. However, research on improving its content through nutrient-induced endogenous synthesis is relatively scarce.

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Background: Observational studies have suggested that gestational age was associated with the risk of epilepsy later in life. However, it remains unclear whether the association is of a causal nature.

Methods: Two-sample Mendelian randomization (MR) was performed to assess the causal effect of fetal gestational age on epilepsy.

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Case Presentation: We report the case of a girl aged 2 years and 10 months who had fever for 2 days, vomiting, poor mental status for 1 day, and one episode of convulsions.

Symptoms And Signs: The patient experienced a rapid onset of symptoms with fever, vomiting, and convulsions. Upon physical examination on admission, she presented with the following: temperature 38.

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Purpose: The purpose of the meta-analysis is to evaluate the association between calpain-10 (CANP10) gene polymorphisms and gestational diabetes mellitus (GDM).

Methods: A computer-based retrieval was performed in Web of Science, Embase and PubMed databases for eligible studies. The genotype data from four variants in CANP10 [single-nucleotide polymorphisms (SNP) 19, 43, 44, and 63] were collected.

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Objective: The aim of this study is to assess the relationship between IL1RN*2 variants and preterm delivery (PTD) risk.

Methods: Eligible studies were searched in Embase and PubMed databases from inception to November 2013. Two investigators identified relevant studies and extracted data of maternal and fetal genotype independently.

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