Causal relationship between complement and colorectal cancer: a drug target Mendelian randomization study.

Background: Colorectal cancer is influenced by several factors such as unhealthy habits and genetic factors. has been linked to a number of malignancies. However, uncertainty surrounds the connection between and CRC.

A new method of pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy: A retrospective analysis of 93 cases.

Introduction: Pancreaticojejunostomy have been studied and modified for more than a hundred years. We investigated a new method of pancreaticojejunostomy to explore its value in laparoscopic pancreaticoduodenectomy.

Patients And Methods: A retrospective analysis was conducted on the clinical data of 93 patients who underwent laparoscopic pancreaticoduodenectomy with 'Shunt-block combined' pancreaticojejunostomy at Ningbo Medical Center Lihuili Hospital from April 2017 to February 2023.

Structure-regulated enhanced Raman scattering on a semiconductor to study temperature-influenced enantioselective identification.

Surface-enhanced Raman scattering (SERS) spectroscopy is an effective technique that can reveal molecular structure and molecular interaction details. Semiconductor-based SERS platforms exhibit multifaceted tunability and unique selectivity to target molecules as well as high spectral reproducibility. However, the detection sensitivity of semiconductors is impeded by inferior SERS enhancement.

Recyclable and flexible Bi(Ho-Yb)OBr/g-CN composite porous fiber for efficient water purification and real-time temperature sensing.

Herein, an electrospinning porous nanofiber with large specific surface area, excellent flexibility, remarkable tensile strength, and high stability of thermal degradation has been developed by loading Ho/Yb co-doped BiOBr/g-CN (BHY/CN) heterojunction photocatalysts on polyacrylonitrile (PAN) nanofibers. The optimized BHY/CN-2 nanofiber demonstrates outstanding photocatalytic activity for the degradation of 98.83% tetracycline (TC, 60 min) and 99.

The impact of urbanization on ecosystem services: Both time and space are important to identify driving forces.

Rapid urbanization is one of the key factors in threatening regional ecological security and undermining human well-being. Understanding of the impacts of urbanization on ecosystem services (ESs) could provide comprehensive information for policy making to support ecological governance. In this study, the spatial and temporal distributions of four ESs, namely water yield (WY), soil conservation (SC), nitrogen export (NE), and habitat quality (HQ), and four factors of urbanization, namely construction land percentage, economic density, population density, and nighttime lighting, were analyzed in the Xiangjiang River Basin (XJRB) from 1990 to 2020.

Construction of High-Active SERS Cavities in a TiO Nanochannels-Based Membrane: A Selective Device for Identifying Volatile Aldehyde Biomarkers.

The accurate, sensitive, and selective on-site screening of volatile aldehyde biomarkers for lung cancer is of utmost significance for preclinical cancer diagnosis and treatment. Applying surface-enhanced Raman scattering (SERS) for gas sensing remains difficult due to the small Raman cross section of most gaseous molecules and interference from other components in exhaled breath. Using an Au asymmetrically coated TiO nanochannel membrane (Au/TiO NM) as the substrate, a ZIF-8-covered Au/TiO NM SERS sensing substrate is designed for the detection of exhaled volatile organic compounds (VOCs).

Effect of aerobic exercise on GRP78 and ATF6 expressions in mice with non-alcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) is a prevalent medical condition with an ever-growing trend. Although multiple intracellular mechanisms are involved, endoplasmic reticulum (ER) stress has been demonstrated to play a significant role in the genesis and progression. Most of the research supports the advantages of exercise for NAFLD.

[Effect of aerobic exercise on AKT/GSK3β mediated hepatocyte apoptosis in nonalcoholic fatty liver disease].

Objective: To investigate the effect of aerobic exercise on AKT/GSK3β pathway-mediated hepatocyte apoptosis in non-alcoholic fatty liver diseases(NAFLD).

Methods: A total of 30 6-week-old male C57BL/6J mice, and mice were fed adaptively for one week. The control group was fed with ordinary diet, and the model group and model exercise group were fed with high-fat diet until 18 weeks.

Hydrophobic interaction enables rapid enrichment of volatile metabolites on Au/TiO based SERS substrates for ultrasensitive bacteria detection.

Bacterial contamination in diets is a major threat to human health and a global health problem. The development of sensitive methods for rapid discrimination of benign and pathogenic bacteria is essential. Herein, using self-standing Au/TiO nanotubes as a surface-enhanced Raman spectroscopy (SERS) substrate, rapid and sensitive bacteria discrimination is achieved the hydrophobic interaction between the volatile metabolites released from pathogenic bacteria and the SERS substrate.

EphA4/EphrinB2 signaling mediates pericyte-induced transient glia limitans formation as a secondary protective barrier after subarachnoid hemorrhage in mice.

Background: Most patients with subarachnoid hemorrhage (SAH) do not exhibit brain parenchymal injury upon imaging but present significant blood-brain barrier (BBB) disruption and secondary neurological deficits. The aim of this study was to investigate whether stressed astrocytes act as a secondary barrier to exert a protective effect after SAH and to investigate the mechanism of glial limitan formation.

Methods: A total of 204 adult male C57BL/6 mice and an endovascular perforation SAH model were employed.

[Research progress on mechanism of exercise improving non-alcoholic fatty liver disease through regulating endoplasmic reticulum stress].

Non-alcoholic fatty liver disease (NAFLD) is one of the main diseases of metabolic syndrome. With the increasing popularity of NAFLD in the world, the prevention and therapy of NAFLD are facing great challenges. In recent years, scholars at home and abroad have carried out a large number of studies on NAFLD, but its pathogenesis is still unclear.

Origin and evolution analysis and genetic characteristics of echovirus 9 in China.

Background: Echovirus 9 (E9) is associated with a wide variety of diseases and medical conditions, and the clinical symptoms of sporadic cases caused by E9 often are severe. With a high global prevalence, E9 has caused multiple outbreaks worldwide. However, little is known about the genetic and geographic population dynamics of E9.

Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study.

The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well established due to insufficient experimental data. The C1 subgenotype of EV71 has not yet been reported in the Chinese mainland by now.

Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway.

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent, and physical exercise represents one of the most effective methods to attenuate NAFLD. However, the mechanism of aerobic exercise improving NAFLD remains unclear. This study aims to investigate the effect of aerobic exercise on CNPY2-PERK pathway in mice with NAFLD.

Molecular analysis of Coxsackievirus A24 variant isolates from three outbreaks of acute hemorrhagic conjunctivitis in 1988, 1994 and 2007 in Beijing, China.

Coxsackievirus A24 variant (CVA24v) is a major pathogen that causes continued outbreaks and pandemics of acute hemorrhagic conjunctivitis (AHC). In China, the first confirmed outbreak of CVA24v-related AHC occurred in Beijing in 1988, followed by another two significant outbreaks respectively in 1994 and 2007, which coincides with the three-stage dynamic distribution of AHC in the world after 1970s. To illustrate the genetic characteristics of CVA24v in different periods, a total of 23 strains were isolated from those three outbreaks and the whole genome of those isolations were sequenced and analyzed.

Assessment of soil erosion in the Dongting Lake Basin, China: Patterns, drivers, and implications.

Soil loss caused by erosion is a global problem. Therefore, the assessment of soil erosion and the its driving mechanism are of great significance to soil conservation. However, soil erosion is affected by both climate change and human activities, which have not been quantified, and few researchers studied the differences in the driving mechanisms of soil erosion depending on the land use type.

Circulation of Type 2 Vaccine-Derived Poliovirus in China in 2018-2019.

Background: China implemented the globally synchronized switch from trivalent oral poliovirus vaccine (tOPV) to bivalent OPV (bOPV) on May 1, 2016. During April 2018 to May 2019, the first outbreak caused by type 2 circulating vaccine-derived poliovirus (cVDPV2) after the switch occurred in Xinjiang and Sichuan, China. We performed sequence analysis of VP1 and the whole genome to determine the genomic characteristics of type 2 cVDPVs, and carried out coverage surveys to assess the risk of viral propagation.

Monsavirus in monkey rectal swab and throat swab specimens in China: Proposal for Posaliviridae as a new family in Picornavirales.

Posa-like viruses have been detected in the fecal samples of several host species and are considered unclassified members of Picornavirales. Here, we identified genomic fragments of novel posa-like viruses (monsaviruses) in monkey specimens through next generation sequencing and obtained 11 full-length genomes. This monsavirus shared 88.

Piperlongumine Attenuates High Calcium/Phosphate-Induced Arterial Calcification by Preserving P53/PTEN Signaling.

Vascular calcification frequently occurs in the process of chronic kidney disease, atherosclerosis and aging, resulting in an increased prevalence of cardiovascular events. Piperlongumine (PLG) is a natural product isolated from L. Here, we aimed to explore the effect of PLG in high calcium- and phosphate-induced vascular calcification and the associated mechanism.

Cultivated Land Change, Driving Forces and Its Impact on Landscape Pattern Changes in the Dongting Lake Basin.

Comprehending the dynamic change characteristics of land use/cover and the driving factors causing the change are prerequisites for protecting land resources. This paper analyzes changes in cultivated land, the driving factors that cause them, and their tremendous impact on landscape pattern changes in the Dongting Lake Basin. For this purpose, we used mathematical statistics, buffer analysis, trend analysis, landscape pattern index, and logistic regression model to analyze the land use data of the study area from 1980 to 2018.

Roux-en-Y gastric bypass surgery restores insulin-mediated glucose partitioning and mitochondrial dynamics in primary myotubes from severely obese humans.

Background/objectives: Impaired insulin-mediated glucose partitioning is an intrinsic metabolic defect in skeletal muscle from severely obese humans (BMI ≥ 40 kg/m). Roux-en-Y gastric bypass (RYGB) surgery has been shown to improve glucose metabolism in severely obese humans. The purpose of the study was to determine the effects of RYGB surgery on glucose partitioning, mitochondrial network morphology, and the markers of mitochondrial dynamics skeletal muscle from severely obese humans.