Publications by authors named "Junguo Yan"
Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction.
View Article and Find Full Text PDFPain is common and frequent in many neurodegenerative diseases, although it has not received much attention. In Huntington's disease (HD), pain is often ignored and under-researched because attention is more focused on motor and cognitive decline than psychiatric symptoms. In HD progression, pain symptoms are complex and involved in multiple etiologies, particularly mental issues such as apathy, anxiety and irritability.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed overcrowding in emergency departments (EDs) in Beijing's teaching hospitals during 2013-2014, revealing over 1.5 million annual visits.
- High-acuity cases represented a small fraction of these visits, with many patients seeking non-urgent care, contributing to crowding.
- Key findings included long wait times for patients who were boarded in EDs and a significant percentage of those who remained in "Observation" beds due to complex health issues or chronic care needs.