Efficacy, Safety, and Population Pharmacokinetics of MW032 Compared With Denosumab for Solid Tumor-Related Bone Metastases: A Randomized, Double-Blind, Phase 3 Equivalence Trial.

Importance: The bioequivalence of denosumab biosimilar has yet to be studied in a 53-week, multicenter, large-scale, and head-to-head trial. A clinically effective biosimilar may help increase access to denosumab in patients with solid tumor-related bone metastases.

Objectives: To establish the biosimilarity of MW032 to denosumab in patients with solid tumor-related bone metastases based on a large-scale head-to-head study.

AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With Exon 19 Deletion or L858R Mutations.

Purpose: Aumolertinib (formerly almonertinib; HS-10296) is a novel third-generation epidermal growth factor receptor tyrosine kinase inhibitor approved in China. This double-blind phase III trial evaluated the efficacy and safety of aumolertinib compared with gefitinib as a first-line treatment for locally advanced or metastatic -mutated non-small-cell lung cancer (NSCLC; ClinicalTrials.gov identifier: NCT03849768).

H/H fault detection observer design for fractional-order singular systems in finite frequency domains.

This paper investigates the robust fault detection observer design problem in finite frequency domains for fractional-order singular systems. An H/H fault detection observer for fractional-order singular systems is designed to meet the system admissibility, disturbance robustness and fault sensitivity indices in finite frequency domains simultaneously. Four theorems and four corollaries about the system admissibility and the performance index H/H in different frequency ranges are given, and then the sufficient conditions are obtained in terms of linear matrix inequalities.

Randomized and dose-escalation trials of recombinant human serum albumin /granulocyte colony-stimulating factor in patients with breast cancer receiving anthracycline-containing chemotherapy.

Background: To evaluate the efficacy and safety of recombinant human serum albumin /granulocyte colony-stimulating factor (rHSA/G-CSF) in breast cancer following receipt of cytotoxic agents.

Methods: The phase 1b trial assessed the pharmacokinetics, pharmacodynamics, and safety of dose-escalation, ranging from rHSA/G-CSF 1800 μg, 2100 μg, and 2400 μg. Randomized controlled phase 2b trial was further conducted to ensure the comparative efficacy and safety of rHSA/G-CSF 2400 μg and rhG-CSF 5 μg/kg.

Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer.

Background: High levels of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) expression in tumour tissues are an indicator of ineffective responses to pemetrexed-based chemotherapy in various tumours, including non-small cell lung cancer (NSCLC). However, tumour tissues are highly heterogeneous, so a single biopsy may not reflect genetic alterations during disease progression. This study investigated the potential use of plasma TS and DHFR mRNA levels as biomarkers for predicting sensitivity to pemetrexed-based chemotherapy.

H control for singular fractional-order interval systems: The 0<α<1 case.

This paper investigates the H control problems of singular fractional-order interval systems with commensurate order 0<α<1. Firstly, novel conditions for the bounded real lemma in the sense of H norm for nominal singular fractional-order systems are proposed, based on which the sufficient conditions for checking the admissibility and H performance of singular fractional-order interval systems are derived. Secondly, the state feedback H controller synthesis for singular fractional-order interval systems is addressed and the state feedback controller is designed.

New Criteria on Finite-Time Stability of Fractional-Order Hopfield Neural Networks With Time Delays.

In this article, the finite-time stability (FTS) of fractional-order Hopfield neural networks with time delays (FHNNTDs) is studied. A widely used inequality in investigating the stability of the fractional-order neural networks is fractional-order Gronwall inequality related to the Mittag-Leffler function, which cannot be directly used to study the stability of the factional-order neural networks with time delays. In the existing works related to fractional-order Gronwall inequality with time delays, the order was divided into two cases: λ ∈ (0,0.

A Phase III, randomized, double-blind, placebo-controlled, multicenter study of fruquintinib in Chinese patients with advanced nonsquamous non-small-cell lung cancer - The FALUCA study.

Objectives: Fruquintinib is an orally active kinase inhibitor that selectively targets the vascular endothelial growth factor (VEGF) receptor. A Phase II trial has demonstrated a significant benefit in progression-free survival (PFS) for fruquintinib-treated patients with locally advanced/metastatic nonsquamous non-small-cell lung cancer (NSCLC) who have progressed after second-line chemotherapy. This Phase III trial is a randomized, double-blind, multicenter trial to confirm fruquintinib's efficacy in the same patient population.

Robust stability of output feedback controlled fractional-order systems with structured uncertainties in all system coefficient matrices.

This paper proposes a new necessary and sufficient condition for the robust stability of output feedback controlled fractional-order systems with structured uncertainties in all system coefficient matrices by using μ-analysis and the Kronecker product. The robust stability problems are converted to the judgment of the singularity of the matrices with uncertainties. Furthermore, the explicit robustness bounds of preserving the asymptotical stability of such systems are established based on the above condition.

Characterization of Phenotypic and Genotypic Traits of from Lung Cancer Patients with Respiratory Infection.

Background: has been a leading healthcare-acquired infection (HAI) agent worldwide for decades. However, the epidemiological characteristics of in lung cancer patients with respiratory infection are unclear. Here, we characterized the frequency of in lung cancer patients with respiratory infection in a cancer hospital in China and determined the antibiotic resistance profile, virulence phenotype and clonal relationships among these strains.

Long noncoding RNA LINC00337 accelerates the non-small-cell lung cancer progression through inhibiting TIMP2 by recruiting DNMT1.

Accumulating evidence reveals the essential roles of long noncoding RNAs (lncRNAs) in the non-small-cell lung cancer (NSCLC) tumorigenesis. Here, our research investigated the biological roles of novel lncRNA LINC00337 in the NSCLC tumorigenesis and discover the potential mechanism. In the NSCLC tissue and cell lines, LINC00337 was found to be remarkedly up-regulated, and the ectopic LINC00337 overexpression indicated the poor survival of NSCLC patients.

Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non-small cell lung cancer by regulating the Wnt/β-catenin pathway.

Circular RNAs (circRNAs) are a large class of RNAs that have previously been identified to be involved in certain diseases, including the development of cancer. However, the role of circ_001569 in non-small cell lung cancer (NSCLC) remains unknown. In the present study, it was demonstrated that expression levels of circ_001569 were significantly increased in NSCLC tissues compared with in adjacent normal tissues.

Fractional order PI controller synthesis for steam turbine speed governing systems.

The current state of the art of fractional order stability theory is hardly to build connection between the time domain analysis and frequency domain synthesis. The existing tuning methodologies for fractional order PID are not always satisfy the given gain crossover frequency and phase margin simultaneously. To overcome the drawbacks in the existing synthesis of fractional order controller, the synthesis of optimal fractional order PI controller for higher-order process is proposed.

Ternary Resistance Switching Memory Behavior Based on Graphene Oxide Embedded in a Polystyrene Polymer Layer.

Nonvolatile ternary memory devices were fabricated using the composite of polystyrene (PS) and graphene oxide(GO) as active layers, which have an reliable intermediate state. The current-voltage (I-V) curves of the indium tin oxide (ITO)/PS+GO/Al device under the external applied voltages exhibited current tri-stability with three conductivity states, which clearly revealed ternary memory performance. Under the stimulus of the external voltage, a stable intermediate conductivity state was observed.

Enhancement of memory margins in the polymer composite of [6,6]-phenyl-C-butyric acid methyl ester and polystyrene.

Memory devices based on composites of polystyrene (PS) and [6,6]-phenyl-C-butyric acid methyl ester (PCBM) were investigated with bistable resistive switching behavior. Current-voltage (I-V) curves for indium-tin-oxide (ITO)/PS + PCBM/Al devices with 33 wt% PCBM showed non-volatile, rewritable, flash memory properties with a maximum ON/OFF current ratio of 1 × 10, which was 100 times larger than the ON/OFF ratio of the device with 5 wt% PCBM. For ITO/PS + PCBM/Al devices with 33 wt% PCBM, the write-read-erase-read test cycles demonstrated the bistable devices with ON and OFF states at the same voltage.

Nonvolatile memory devices based on poly(vinyl alcohol) + graphene oxide hybrid composites.

Nonvolatile memory devices based on active layers of poly(vinyl alcohol) (PVA) + graphene oxide (GO) hybrid composites have been fabricated. The performance of the ITO/PVA + GO/Al device was compared with that of the ITO/PVA/Al device. The ITO/PVA + GO/Al device showed excellent performance compared to the ITO/PVA/Al device (an ON/OFF resistance ratio of 1.

Focused Role of an Organic Small-Molecule PBD on Performance of the Bistable Resistive Switching.

An undoped organic small-molecule 2-(4-tert-butylphenyl)-5-(4-biphenylyl)-1,3,4-oxadiazole (PBD) and a kind of nanocomposite blending poly(methyl methacrylate) (PMMA) into PBD are employed to implement bistable resistive switching. For the bistable resistive switching indium tin oxide (ITO)/PBD/Al, its ON/OFF current ratio can touch 6. What is more, the ON/OFF current ratio, approaching to 10(4), is available due to the storage layer PBD:PMMA with the chemical composition 1:1 in the bistable resistive switching ITO/PBD:PMMA/Al.

Robust stability and stabilization of fractional order linear systems with positive real uncertainty.

This paper investigates the robust stability and stabilization of fractional order linear systems with positive real uncertainty. Firstly, sufficient conditions for the asymptotical stability of such uncertain fractional order systems are presented. Secondly, the existence conditions and design methods of the state feedback controller, static output feedback controller and observer-based controller for asymptotically stabilizing such uncertain fractional order systems are derived.