Humoral and T-cell responses to SARS-CoV-2 vaccination in multiple sclerosis patients treated with ocrelizumab.

Background: The COVID-19 epidemic raises important questions about the efficacy of vaccines for people treated with ocrelizumab, an anti-CD20 therapy. Ocrelizumab has been shown to reduce the humoral response to SARS-CoV-2 infection and vaccination, but the T-cell response to vaccination has not been fully characterized. We sought to provide data regarding B and T-cell mediated responses to SARS-CoV-2 vaccination in ocrelizumab-treated patients, and to determine what variables correlate with vaccine immunogenicity.

Improved imaging using Mn He-α x rays at OMEGA EP.

In this paper, we report on a crystal based x-ray imaging system fielded at the OMEGA EP laser facility. This new system has a pointing accuracy of +/100 μm, a temporal resolution down to 100 ps (depending on backlighter characteristics), variable magnification, and a spatial resolution of 21.9 µm at the object plane at a magnification of 15×.

The Scattered Light Time-history Diagnostic suite at the National Ignition Facility.

The Scattered Light Time-history Diagnostic (SLTD) is being implemented at the National Ignition Facility (NIF) to greatly expand the angular coverage of absolute scattered-light measurements for direct- and indirect-drive inertial confinement fusion (ICF) experiments. The SLTD array will ultimately consist of 15 units mounted at a variety of polar and azimuthal angles on the NIF target chamber, complementing the existing NIF backscatter suite. Each SLTD unit collects and diffuses scattered light onto a set of three optical fibers, which transport the light to filtered photodiodes to measure scattered light in different wavelength bands: stimulated Brillouin scattering (350 nm-352 nm), stimulated Raman scattering (430 nm-760 nm), and ω/2 (695 nm-745 nm).

Disparities in influenza vaccination: Arab Americans in California.

Background: Influenza vaccination among minoritized groups remains below federal benchmarks in the United States (US). We used data from the 2004-2016 California Health Interview Surveys (CHIS) to characterize influenza vaccination patterns among Arab Americans in California.

Methods: Influenza vaccination was self-reported by Arab American adults (N = 1163) and non-Hispanic Whites (NHW, N = 166,955).

Characterization of shaped Bragg crystal assemblies for narrowband x-ray imaging.

X-ray imaging using shaped crystals in Bragg reflection is a powerful technique used in high-energy-density physics experiments. The characterization of these crystal assemblies with conventional x-ray sources is very difficult because of the required angular resolution of the order of ∼10 rad and the narrow bandwidth of the crystal. The 10-J, 1-ps Multi-Terawatt (MTW) laser at the Laboratory for Laser Energetics was used to characterize a set of Bragg crystal assemblies.

A high-resolving-power x-ray spectrometer for the OMEGA EP Laser (invited).

A high-resolving-power x-ray spectrometer has been developed for the OMEGA EP Laser System based on a spherically bent Si [220] crystal with a radius of curvature of 330 mm and a Spectral Instruments (SI) 800 Series charge-coupled device. The instrument measures time-integrated x-ray emission spectra in the 7.97- to 8.

Two-color spatial and temporal temperature measurements using a streaked soft x-ray imager.

A dual-channel streaked soft x-ray imager has been designed and used on high energy-density physics experiments at the National Ignition Facility. This streaked imager creates two images of the same x-ray source using two slit apertures and a single shallow angle reflection from a nickel mirror. Thin filters are used to create narrow band pass images at 510 eV and 360 eV.

A new streaked soft x-ray imager for the National Ignition Facility.

A new streaked soft x-ray imager has been designed for use on high energy-density (HED) physics experiments at the National Ignition Facility based at the Lawrence Livermore National Laboratory. This streaked imager uses a slit aperture, single shallow angle reflection from a nickel mirror, and soft x-ray filtering to, when coupled to one of the NIF's x-ray streak cameras, record a 4× magnification, one-dimensional image of an x-ray source with a spatial resolution of less than 90 μm. The energy band pass produced depends upon the filter material used; for the first qualification shots, vanadium and silver-on-titanium filters were used to gate on photon energy ranges of approximately 300-510 eV and 200-400 eV, respectively.

Soft x-ray backlighting of cryogenic implosions using a narrowband crystal imaging system (invited).

A high-performance cryogenic DT inertial confinement fusion implosion experiment is an especially challenging backlighting configuration because of the high self-emission of the core at stagnation and the low opacity of the DT shell. High-energy petawatt lasers such as OMEGA EP promise significantly improved backlighting capabilities by generating high x-ray intensities and short emission times. A narrowband x-ray imager with an astigmatism-corrected bent quartz crystal for the Si Heα line at ∼1.

Shell trajectory measurements from direct-drive implosion experiments.

A technique to measure the shell trajectory in direct-drive inertial confinement fusion implosions is presented. The x-ray self emission of the target is measured with an x-ray framing camera. Optimized filtering limits the x-ray emission from the corona plasma, isolating a sharp intensity gradient very near the ablation surface.

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam.

A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L.

Soft x-ray backlighting of direct-drive implosions using a spherical crystal imager on OMEGA.

Using a spherically bent quartz crystal for the Si He(α) line at ~1.865 keV, a narrowband x-ray imager has been deployed at the Omega Laser Facility to record backlit images of direct-drive laser implosions. The crystal was cut along the 1011 planes for a 2d spacing of 0.

Time-resolved measurements of hot-electron equilibration dynamics in high-intensity laser interactions with thin-foil solid targets.

Time-resolved K(α) spectroscopy has been used to infer the hot-electron equilibration dynamics in high-intensity laser interactions with picosecond pulses and thin-foil solid targets. The measured K(α)-emission pulse width increases from ~3 to 6 ps for laser intensities from ~10(18) to 10(19) W/cm(2). Collisional energy-transfer model calculations suggest that hot electrons with mean energies from ~0.

Phase-conjugate Fizeau interferometer.

We describe a phase-conjugate interferometer that consists of a partially transmitting conventional mirror placed in front of and in close proximity to a phase-conjugate mirror. The interferometer is self-referencing, compact, and insensitive to environmental disturbances, provides twice the sensitivity of conventional (nonphase-conjugate) interferometers, and produces a direct representation of an incident wave front. We have constructed such a device using internally self-pumped phase conjugation in barium titanate and have used the device to characterize the wave front produced by an aberrated optical system.