Tag attachment innovation on spurdog (Squalus acanthias) reveals year-round coastal association of pregnant females in northeastern Atlantic waters.

The spurdog (Squalus acanthias Linnaeus, 1758) is a globally distributed squaliform shark that has historically been overfished but is now recovering in the northeast Atlantic. Data series on spurdog movement and habitat use have been somewhat limited to research surveys due to challenges associated with electronic tagging. Here, we offer a revised attachment method for externally attached pop-up satellite archival tags that was successful in long-term deployments on pregnant females.

How Infants Direct Their Gaze to Faces in the Presence of Other Objects: The Development of Face Preference Between 4 and 7 Months After Birth.

From early in development, infants process faces in their environment differentially from other items. By around 6 months of age, they are able to orient toward faces in the presence of distractor items. This paper aimed to assess whether this preferential looking toward faces was observable prior to 6 months of age, and whether there were developmental trends.

The role of dyadic combinations of infants' behaviors and caregivers' verbal and multimodal responses in predicting vocabulary outcomes.

There is robust evidence that infants' gestures and vocalisations and caregivers' contingent responses predict later child vocabulary. Recent studies suggest that dyadic combinations of infants' behaviors and caregivers' responses are more robust predictors of children's vocabularies than these behaviors separately. Previous studies have not yet systematically compared different types of dyadic combinations.

Seasonal habitat use and diel vertical migration in female spurdog in Nordic waters.

Background: Studying habitat use and vertical movement patterns of individual fish over continuous time and space is innately challenging and has therefore largely remained elusive for a wide range of species. Amongst sharks, this applies particularly to smaller-bodied and less wide-ranging species such as the spurdog (Squalus acanthias Linnaeus, 1758), which, despite its importance for fisheries, has received limited attention in biologging and biotelemetry studies, particularly in the North-East Atlantic.

Methods: To investigate seasonal variations in fine-scale niche use and vertical movement patterns in female spurdog, we used archival data from 19 pregnant individuals that were satellite-tagged for up to 365 days in Norwegian fjords.

Examining Dutch children's vocabularies across infancy and toddlerhood: Demographic effects are age-specific and task-specific.

Limited studies have examined demographic differences in children's vocabulary in longitudinal samples, while there are questions regarding the duration, direction, and magnitude of these effects across development. In this longitudinal study, we included over 400 Dutch children. Caregivers filled out N-CDIs when children were 9-11 months (measuring word comprehension, word production, and gestures) and around 2-5 years of age (measuring word production).

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers.

Background: The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers.

Methods: Patients aged 50-74 years with cerebrospinal fluid (CSF) biomarker-confirmed AD, were recruited to clinical trial (NCT03186989 since June 14, 2017). Baseline demographics, disease characteristics, and biomarkers were evaluated in 45 patients according to BCHE-K and APOE4 allelic status in this post-hoc study.

Predicting the future of our oceans-Evaluating genomic forecasting approaches in marine species.

Climate change is restructuring biodiversity on multiple scales and there is a pressing need to understand the downstream ecological and genomic consequences of this change. Recent advancements in the field of eco-evolutionary genomics have sought to include evolutionary processes in forecasting species' responses to climate change (e.g.

Women are expected to smile: Preliminary evidence for the role of gender in the neurophysiological processing of adult emotional faces in 3-year-old children.

Children form stereotyped expectations about the appropriateness of certain emotions for men versus women during the preschool years, based on cues from their social environments. Although ample research has examined the development of gender stereotypes in children, little is known about the neural responses that underlie the processing of gender-stereotyped emotions in children. Therefore, the current study examined whether 3-year-olds differ in the neural processing of emotional stimuli that violate gender stereotypes (i.

Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease: A Randomized Clinical Trial.

Importance: Accumulation of hyperphosphorylated, tangled microtubule-associated protein tau (MAPT) is a pathological hallmark of Alzheimer disease (AD) associated with disease progression and cognitive decline.

Objective: To evaluate the effect of tau synthesis reduction on tau biomarkers in patients with mild AD.

Design, Setting, And Participants: This randomized clinical trial was a double-blind, placebo-controlled 36-week multiple-ascending dose (MAD) phase 1b trial (October 2017 to September 2020), followed by a 64- or 71-week open-label long-term extension (LTE) (October 2019 to May 2022).

Regional Cortical Thickness Correlates of Intellectual Abilities Differ in Children With Traumatic Brain Injury Versus Those With Orthopedic Injury in the Chronic Post-Injury Phase.

A decline in intellectual functioning (intelligence quotient [IQ]) is often observed following more severe forms of traumatic brain injury (TBI) and is a useful index for long-term outcome. Identifying brain correlates of IQ can serve to inform developmental trajectories of behavior in this population. Using magnetic resonance imaging (MRI), we examined the relationship between intellectual abilities and patterns of cortical thickness in children with a history of TBI or with orthopedic injury (OI) in the chronic phase of injury recovery.

Robustness of the cognitive gains in 7-month-old bilingual infants: A close multi-center replication of Kovács and Mehler (2009).

We present an exact replication of Experiment 2 from Kovács and Mehler's 2009 study, which showed that 7-month-old infants who are raised bilingually exhibit a cognitive advantage. In the experiment, a sound cue, following an AAB or ABB pattern, predicted the appearance of a visual stimulus on the screen. The stimulus appeared on one side of the screen for nine trials and then switched to the other side.

Pelizaeus-Merzbacher Disease: A Caregiver Assessment of Disease Impact.

Pelizaeus-Merzbacher disease is a rare X-linked leukodystrophy accompanied by central nervous system hypomyelination with a spectrum of clinical phenotypes. This is the first survey of caregivers of individuals with Pelizaeus-Merzbacher disease to investigate the presenting symptoms, path to diagnosis, identity and impact of most bothersome symptoms, and needs that future treatment should address. One hundred participants completed the survey.

Face-to-face contact during infancy: How the development of gaze to faces feeds into infants' vocabulary outcomes.

Infants acquire their first words through interactions with social partners. In the first year of life, infants receive a high frequency of visual and auditory input from faces, making faces a potential strong social cue in facilitating word-to-world mappings. In this position paper, we review how and when infant gaze to faces is likely to support their subsequent vocabulary outcomes.

Surface-based abnormalities of the executive frontostriatial circuit in pediatric TBI.

Childhood traumatic brain injury (TBI) is one of the most common causes of acquired disability and has significant implications for executive functions (EF), such as impaired attention, planning, and initiation that are predictive of everyday functioning. Evidence has suggested attentional features of executive functioning require behavioral flexibility that is dependent on frontostriatial circuitry. The purpose of this study was to evaluate surface-based deformation of a specific frontostriatial circuit in pediatric TBI and its role in EF.

Robustness of the rule-learning effect in 7-month-old infants: A close, multicenter replication of Marcus et al. (1999).

We conducted a close replication of the seminal work by Marcus and colleagues from 1999, which showed that after a brief auditory exposure phase, 7-month-old infants were able to learn and generalize a rule to novel syllables not previously present in the exposure phase. This work became the foundation for the theoretical framework by which we assume that infants are able to learn abstract representations and generalize linguistic rules. While some extensions on the original work have shown evidence of rule learning, the outcomes are mixed, and an exact replication of Marcus et al.

The Vocabulary of Infants with an Elevated Likelihood and Diagnosis of Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Infant Language Studies Using the CDI and MSEL.

Diagnoses of autism spectrum disorder (ASD) are typically accompanied by atypical language development, which can be noticeable even before diagnosis. The siblings of children diagnosed with ASD are at elevated likelihood for ASD diagnosis and have been shown to have higher prevalence rates than the general population. In this paper, we systematically reviewed studies looking at the vocabulary size and development of infants with autism.

Of three sharks and one chimaera: varied habitat preferences across a latitudinal range revealed by coastal and offshore surveys.

Using national and international research survey data and applying a combination of models and mapping tools, this study revealed temperature and depth as the crucial environmental drivers of both the distribution and the abundance of four benthopelagic chondrichthyans inhabiting Norwegian and Icelandic waters: rabbitfish (Chimaera monstrosa), velvet-belly lanternshark (Etmopterus spinax), blackmouth catshark (Galeus melastomus) and spurdog (Squalus acanthias). C. monstrosa and E.

Development of the N400 for Word Learning in the First 2 Years of Life: A Systematic Review.

The N400 ERP component is a direct neural index of word meaning. Studies show that the N400 component is already present in early infancy, albeit often delayed. Many researchers capitalize on this finding, using the N400 component to better understand how early language acquisition unfolds.

Two-year-olds at elevated risk for ASD can learn novel words from their parents.

Children diagnosed with autism spectrum disorder (ASD) often have smaller vocabularies in infancy compared to typically-developing children. To understand whether their smaller vocabularies stem from problems in learning, our study compared a prospective risk sample of 18 elevated risk and 11 lower risk 24-month-olds on current vocabulary size and word learning ability using a paradigm in which parents teach their child words. Results revealed that both groups learned novel words, even though parents indicated that infants at elevated risk of ASD knew fewer words.

Severe recalled labor pain and elective cesarean section in a subsequent delivery: a cohort study of Norwegian parous women.

Introduction: Some women keep on recalling intense labor pain experienced at childbirth to a degree that may negatively affect their life during the postpartum period or lead them to request a cesarean section (CS) in the subsequent delivery. This longitudinal study aimed to assess the impact of severe recalled labor pain from the previous birth on the preference for and delivery by an elective CS in the subsequent delivery. Furthermore, we investigated whether co-occurring maternal demographic, somatic and mental health factors related to the previous and subsequent delivery, explain parts of a potential association.