Publications by authors named "Jung-Wook Huh"
Background: Despite advancements in laparoscopic right hemicolectomy for right-sided colon cancer, the choice between functional end-to-end anastomosis and end-to-side anastomosis remains a topic of debate. This study aimed to compare these 2 techniques in terms of postoperative complications and disease-free survival.
Methods: This retrospective analysis included 1,202 patients who underwent laparoscopic right hemicolectomy for nonmetastatic colon cancer at Samsung Medical Center between January 2007 and February 2016.
Purpose: Right-sided tumors have been reported to have a poorer survival rate than left-sided tumors; however, there remains debate regarding whether sidedness is an independent prognostic factor in colorectal cancer liver metastasis (CRLM). This study aimed to assess the impact of sidedness on prognosis in resectable CRLM and to identify prognostic factors.
Methods: Patients who underwent liver resection for CRLM at Samsung Medical Center from January 2008 to December 2021 were included in the investigation.
Article Synopsis
- Neoadjuvant chemoradiotherapy may reduce the presence of exfoliated cancer cells in patients undergoing rectal washout surgery.
- A study involving 105 patients showed that those treated with chemoradiotherapy had a 0.0% rate of malignant cells in washout fluids, compared to 32.1% in those who did not receive the treatment.
- The findings suggest that rectal washout may not be needed for patients who have undergone neoadjuvant chemoradiotherapy, as it appears to effectively minimize the risk of local recurrence from exfoliated cancer cells.
Article Synopsis
- This study evaluates the effectiveness of colonoscopy in detecting recurrence of stage I colorectal cancer and identifies important recurrence risk factors.
- A retrospective analysis of over 2,200 patients showed high 5-year disease-free survival rates, but a small percentage experienced recurrence, with distinct patterns for colon and rectal cancer.
- The findings suggest that relying only on colonoscopy may miss significant recurrence cases, especially for high-risk patients who may benefit from additional CT scans for better detection and outcomes.
Article Synopsis
- * Methods: It analyzed data from 682 patients treated with neoadjuvant chemoradiotherapy and total mesorectal excision at Samsung Medical Center, using various imaging methods to assess clinical staging and outcomes.
- * Results: Findings indicated that local recurrence occurred in 6.9% of patients, with positive circumferential resection margins, venous invasion, and perineural invasion as key risk factors; patients with complete resections had better survival rates, reinforcing the need for careful monitoring of high-risk individuals.
Purpose: For the treatment of locally advanced rectal cancer (LARC), research on primary lesions with mesorectal fascia (MRF) involvement is lacking. This study analyzed the clinical outcomes and efficacy of dose-escalated neoadjuvant concurrent chemoradiotherapy (NCRT) to patients with LARC involving MRF.
Materials And Methods: We retrospectively reviewed 301 patients who were diagnosed with LARC involving MRF and underwent NCRT followed by total mesorectal excision (TME).
Article Synopsis
- - The study re-evaluates the assumption that colorectal carcinoma in situ (early-stage cancer) has no risk of spreading to nearby lymph nodes, noting isolated cases of metastasis and recurrence.
- - A retrospective analysis of 1,069 patients showed a low recurrence rate of 0.46%, but some cases revealed lymph node metastasis and distant spread of cancer after surgery.
- - The findings highlight the importance of thorough assessments during diagnosis, as colorectal carcinoma in situ can indeed recur and metastasize, necessitating careful monitoring of patients.
Objectives: This research delves into the application of texture analysis in spine computed tomography (CT) scans and its correlation with bone mineral density (BMD), as determined by dual-energy X-ray absorptiometry (DXA). It specifically addresses the discordance between the 2 measurements, suggesting that certain spinal-specific factors may contribute to this discrepancy.
Methods: The study involved 405 cases from a single institution collected between May 6, 2012 and June 30, 2021.
Article Synopsis
- The study focused on identifying prognostic factors for survival in 474 patients with locally advanced rectal cancer who showed strong treatment responses after neoadjuvant chemoradiotherapy.
- The analysis revealed that the circumferential resection margin and the use of adjuvant chemotherapy positively influenced disease-free survival, while the clinical N stage also played a role in overall survival.
- The study recommends close monitoring and consideration of adjuvant chemotherapy for patients with specific risk factors, such as a positive circumferential resection margin and clinical N (+) stage.
Article Synopsis
- This study compared long-term cancer outcomes between robotic and laparoscopic surgeries in patients with advanced rectal cancer after they received neoadjuvant chemoradiotherapy (nCRT).
- It analyzed data from 3240 rectal cancer patients, focusing on 1204 who received nCRT, and used propensity score matching to ensure fair comparisons between the two surgical methods.
- The results showed that the robotic surgery group had better 5-year disease-free and local recurrence-free survival rates, especially in patients with yp stage III cancer and other unfavorable factors, suggesting that robotic surgery may yield better oncologic outcomes.
Background: Femoral neck fractures are effectively treated with bipolar hemiarthroplasty (BHA) surgery, yet postoperative pain management remains a challenge. This study explores the efficacy of multimodal pain management in minimizing opioid use and enhancing recovery.
Methods: A retrospective analysis of 87 patients who underwent BHA between September 2016 and September 2020 was conducted.
Background: The lungs are one of the most common sites for colon cancer metastasis. A few studies reported that approximately 2% to 10% of patients with colon cancer developed pulmonary metastasis. However, among these studies, patient characteristics were heterogeneous, and information on pulmonary metastasis incidence by the TNM stage was scarce.
View Article and Find Full Text PDFBackground: This research explores the application of morphometric texture analysis in chest Computed Tomography (CT) scans for determining Bone Mineral Content (BMC) and its temporal changes, both crucial in diagnosing osteoporosis. The study establishes an innovative approach to osteoporosis screening by leveraging Hounsfield Units (HUs) in CT scans to evaluate BMC, offering a comparison with dual-energy X-ray absorptiometry (DXA)-based BMC.
Methods: A total of 806 instances (encompassing 379 individuals) were meticulously compiled from a sole institution, during the period stretching from 6 May 2012 to 30 June 2020.
Background: Highlighting a gap in comprehending bone microarchitecture's intricacies using dual-energy X-ray absorptiometry (DXA), this study aims to bridge this chasm by analyzing texture in non-weight bearing regions on axial computed tomography (CT) scans. Our goal is to enrich osteoporosis patient management by enhancing bone quality and microarchitecture insights.
Methods: Conducted at Busan Medical Center from March 1, 2013, to August 30, 2022, 1,320 cases (782 patients) were screened.
: This study aimed to develop a novel method for opportunistically screening osteoporosis by measuring bone mineral density (BMD) from CT images. We addressed the limitations of commercially available software and introduced texture analysis using Hounsfield units (HU) as an alternative approach. : A total of 458 samples (296 patients) were selected from a dataset of 1320 cases (782 patients) between 1 March 2013, and 30 August 2022.
View Article and Find Full Text PDFPurpose: This study investigates the relationship between preoperative neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-C-reactive protein ratio (LCR), albumin, and 2-year mortality in elderly patients having hemiarthroplasty for displaced femoral neck fracture (FNF).
Materials And Methods: We retrospectively reviewed 284 elderly patients who underwent hemiarthroplasty for Garden type IV FNF from September 2014 to September 2020. Using the receiver operating characteristic curve, optimal cutoff values for LCR, NLR, and albumin were established, and patients were categorized as low or high.
Background: This study aimed to validate the application of CT texture analysis in estimating Bone Mineral Density (BMD) in patients with Type 2 Diabetes (T2D) and comparing it with the results of dual-energy X-ray absorptiometry (DXA) in a normative cohort.
Methods: We analyzed a total of 510 cases (145 T2D patients and 365 normal patients) from a single institution. DXA-derived BMD and CT texture analysis-estimated BMD were compared for each participant.
Alterations in DNA methylation play an important pathophysiological role in the development and progression of colorectal cancer. We comprehensively profiled DNA methylation alterations in 165 Korean patients with colorectal cancer (CRC), and conducted an in-depth investigation of cancer-specific methylation patterns. Our analysis of the tumor samples revealed a significant presence of hypomethylated probes, primarily within the gene body regions; few hypermethylated sites were observed, which were mostly enriched in promoter-like and CpG island regions.
View Article and Find Full Text PDFPurpose: Below knee amputation (BKA) is a common surgical procedure for diabetic foot ulcers and necrotizing lower limb fasciitis patients. However, it is a painful procedure and inadequate postoperative analgesia impedes rehabilitation and prolongs hospitalization. An ideal pain management regimen should provide superior analgesia while minimizing opioid consumption and improving rehabilitation.
View Article and Find Full Text PDFBackground: The association of a micropapillary pattern with oncologic outcomes has not been fully studied in patients with colon cancer.
Objective: We evaluated the prognostic value of a micropapillary pattern, especially for patients with stage II colon cancer.
Design: A retrospective comparative cohort study using propensity score matching.
Background: Mucinous adenocarcinoma is a rare histologic feature of colorectal cancer and is characterized by oncologic features that are different from those of adenocarcinoma. However, there are conflicting views regarding the prognostic impact of mucinous adenocarcinoma on colon cancer.
Objective: This study aimed to evaluate the prognostic impact of mucinous adenocarcinoma in stage II and III colon cancer.
Purpose: Various clinical practice guidelines recommend at least 12 regional lymph nodes should be removed for resected colon cancer. According to a recent study, the lymph node yield (LNY) in colon cancer surgery in the last 20 years has tended to increase from 14.91 to 21.
View Article and Find Full Text PDFBackground: This study aimed to compare the short-term postoperative outcomes of single-port robotic (SPR) using da Vinci SP system and single port laparoscopic (SPL) right hemicolectomy and determine whether the novel SPR system is safe and feasible.
Methods: From January 2019 to December 2020, a total of 141 patients (41 patients for SPR and 100 patients for SPL) who electively underwent right hemicolectomy for colon cancer performed by a single surgeon were included in the study.
Results: The time to the first bowel movement was 3 (range, 1-4) days after surgery in the SPR group and 3 (2-9, range) days in the SPL group (p = 0.
Objective: This study aimed to evaluate the association between distress at initial diagnosis and disease-free survival in patients with resectable colon cancer.
Summary Background Data: Considerable research has examined the psychological impact of having a confirmed diagnosis of cancer, but relatively limited research has examined the impact of distress during the diagnostic phase on oncological outcomes.
Methods: This is a retrospective cohort study.