Publications by authors named "Jung-Taek Yoon"
Epidemiological and experimental carcinogenesis studies provide evidence that components of garlic (Allium sativum) have anticancer activity. We recently reported that the garlic derivative S-allylmercaptocysteine (SAMC) inhibits growth, arrests cells in G(2)-M, and induces apoptosis in human colon cancer cells (Shirin et al., Cancer Res.
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- Exisulind and its derivatives, CP248 and CP461, have previously demonstrated the ability to inhibit growth and induce apoptosis in various human cancer cell lines, but their effects on glioma cell lines were previously unexplored.
- In this study, all three compounds significantly inhibited growth in multiple rat and human glioma cell lines, with CP248 showing the strongest effect, alongside unique properties that caused mitotic arrest in glioma cells.
- CP248 was identified as a potential new treatment for glioblastoma due to its dual action on microtubules and protein kinase G, demonstrating both stabilization and depolymerization effects on microtubules depending on concentration.