Publications by authors named "Jung-Kang Jin"
Background: Aberrant Ca handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca handling is essential for the development of strategies to blunt pathological changes in calcium dynamics. The peptidyl-prolyl - isomerase peptidyl-prolyl isomerase 1 (Pin1) is a critical mediator of myocardial hypertrophy development and cardiac progenitor cell cycle.
View Article and Find Full Text PDFRationale: Endoplasmic reticulum (ER) stress causes the accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha), which induces ER stress response genes. Myocardial ischemia induces the ER stress response; however, neither the function of this response nor whether it is mediated by ATF6 is known.
Objective: Here, we examined the effects of blocking the ATF6-mediated ER stress response on ischemia/reperfusion (I/R) in cardiac myocytes and mouse hearts.
Article Synopsis
- ADAM family proteins, particularly ADAM2, are crucial for male reproduction, facilitating sperm interactions and movement in the female reproductive tract.
- Research involved creating antibodies to study ADAM2 in mice, monkeys, and humans, revealing differences in its association with other proteins and its presence in reproductive tissues.
- Findings indicated that while ADAM2 is found in monkey and mouse sperm, it is absent in human sperm, highlighting species-specific differences in reproductive function.
The receptor tyrosine kinase, MET, has been implicated in tumorigenesis and metastasis of many solid tumors, by multiple mechanisms, including cross talk with epidermal growth factor receptor. In this study, we examined the role of insulin-like growth factor receptor-1 (IGF-1R) signaling in MET activation, focusing on prostate cancer cells. Stimulation of the prostate cancer cell line PC3 with IGF-1 induces a delayed phosphorylation of MET at multiple sites (indicative of full activation), reaching a maximum 18 hr after IGF-1 addition.
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- Prostate cancer cells must survive in the bloodstream for metastasis, and the study reveals that β1 integrins and FAK activation increase during their progression.
- Highly metastatic PC3 and PC3-mm2 cells show continuous β1 integrin activation, correlating with their ability to resist anoikis, while low-metastatic cells like LNCaP and C4-2B4 have less activation.
- Targeting β1 integrins with a specific antibody, mAb 33B6, significantly reduces adhesion and increases apoptosis in PC3-mm2 cells, indicating it could be a promising approach to prevent prostate cancer metastasis.
Article Synopsis
- Acute gastrointestinal dilation is a condition where the stomach and intestines become overstretched due to excessive gas, which is rarely seen in laboratory monkeys.
- Two rhesus monkeys at the Korea National Primate Research Center experienced this condition; one died suddenly after anesthesia, while the other died after treatment, with necropsies revealing severe lung and intestinal congestion.
- The presence of non-gas-forming bacteria in their gastrointestinal contents suggests that the condition was likely caused by a combination of factors, including diet, anesthesia, and excessive water intake, rather than an infection by gas-producing bacteria.
Ovarian cyst is common incidental finding in humans and many animals and includes follicular cysts, cystic rete ovarii and mesonephric duct cysts. Ovarian cyst is often associated with reproductive disorders in humans and animals. We found accidentally bilateral cystic masses in ovaries in an African green monkey.
View Article and Find Full Text PDFProstate cancer is a complex disease in which metastasis to the bone is the main cause of death. Initial stages of metastasis are generally similar to those for most solid tumors; however, the mechanisms that underlie the homing of prostate tumor cells to the bone are not completely understood. Prostate cancer bone metastasis is also a microenvironment-driven disease, involving bidirectional interactions between the tumor and the bone microenvironment.
View Article and Find Full Text PDFTwo inhibitors, aviglycine and propargylglycine, were tested for their ability to suppress methionine synthesis thus inhibit conidial germination and mycelial growth of Czapek-Dox liquid medium grown Fusarium oxysporum f. sp. luffaemuM.
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