Publications by authors named "Jung-Eun Park"

Skin inflammation, characterized by redness, swelling, and discomfort, is exacerbated by oxidative stress, where compounds like 7-methylsulfonylheptyl isothiocyanate (7-MSI) from cruciferous plants exhibit promising antioxidant and anti-inflammatory properties, though their effects on skin aging and underlying mechanisms involving the NLRP3 inflammasome and autophagy are not fully elucidated. NLRP3 is a crucial inflammasome involved in regulating inflammatory responses, and our study addresses its activation and associated physiological effects. Using biochemical assays such as ELISA, RT-qPCR, Western blotting, confocal microscopy, and RNA interference, we evaluated 7-MSI's impact on cytokine production, protein expression, and genetic regulation in Raw 264.

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Infectious diseases caused by fungal sources are of great interest owing to their increasing prevalence. Invasive fungal infections, including invasive pulmonary aspergillosis caused by , and pneumonia caused by , are significant causes of morbidity and mortality among immunocompromised patients. The accurate and timely detection of these pathogens in this high-risk population is crucial for effective patient management.

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The bacterium Vibrio vulnificus causes fatal septicemia in humans. Previously, we reported that an extracellular metalloprotease, vEP-45, secreted by V. vulnificus, undergoes self-proteolysis to generate a 34 kDa protease (vEP-34) by losing its C-terminal domain to produce the C-ter100 peptide.

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Most coronavirus vaccines focus on the spike (S) antigen, but the frequent mutations in S raise concerns about the vaccine efficacy against new variants. Although additional antigens with conserved sequences are have been tested, the extent to which these vaccines can provide immunity against different coronavirus species remains unclear. In this study, we assessed the potential of nucleocapsid (N) as a coronavirus vaccine antigen.

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Microglia are primarily involved in inflammatory reactions and oxidative stress in the brain; as such reducing microglial activation has been proposed as a potential therapeutic strategy for neurodegenerative disorders. Herein, we investigated the anti-inflammatory and antioxidant activities of coniferaldehyde (CFA), a naturally occurring cinnamaldehyde derivative, on activated microglia to evaluate its therapeutic potential. CFA inhibited the production of nitric oxide (NO) and proinflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells.

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Article Synopsis
  • - The study evaluates the health risks associated with CMIT and MIT, commonly found in disinfectants, by examining their effects on the respiratory system in animal models.
  • - Researchers used radiolabeled compounds and advanced techniques to observe significant retention of CMIT/MIT in lung tissue and identified metabolites linked to potential toxicity.
  • - Findings suggest that CMIT/MIT can bind to important biological molecules, leading to irreversible damage and oxidative stress, emphasizing the need for stricter safety measures regarding these chemicals.
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Background: Alzheimer's disease (AD) is a neurodegenerative disorder influenced by age, sex, genetic factors, immune alterations, and infections. Multiple lines of evidence suggest that changes in antibody response are linked to AD pathology.

Methods: To elucidate the mechanisms underlying AD development, we investigated antibodies that target autoimmune epitopes using high-resolution epitope microarrays.

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The current study aimed to investigate the distinct outcomes of table salt and salt in on blood pressure (BP). Animals were divided into 3 groups, including normal diet (NS, 0.5 % NaCl), high-salt diet (HS, normal diet with 8 % NaCl), or high-salt diet (HSG, normal diet with containing 8 % NaCl).

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This study aims to determine the association between UpH (<5.5), Community Periodontal Index (CPI), and the number of remaining teeth-cumulative indicators of oral health-using data from the 7 Korea National Health and Nutrition Examination Survey (KNHANES, 2016-2018), which represents the Korean population. Data from 12,689 adults aged 19 years and older who had periodontal examinations were analyzed.

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Introduction: Fundamental questions remain about the key mechanisms that initiate Alzheimer's disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically engineered marmosets that carry knock-in (KI) point mutations in the presenilin 1 (PSEN1) gene that can be studied from birth throughout lifespan.

Methods: CRISPR/Cas9 was used to generate marmosets with C410Y or A426P point mutations in PSEN1.

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Porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome coronavirus (SADS-CoV) cause intestinal diseases with similar manifestations in suckling piglets. In this study, we developed a multiplex real-time PCR for differential diagnosis of PEDV, PDCoV, and SADS-CoV. The assay demonstrated high specificity with a detection limit of 5 copies/µl for each virus.

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HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We observe that approximately 1-5% of CD4 T cells from the blood of people living with HIV-1 exhibit over-duplicated centrioles, suggesting that centrosome amplification underlies the development of HIV-1-associated cancers by driving aneuploidy.

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Porcine epidemic diarrhea (PED) is a swine-wasting disease caused by coronavirus infection. It causes great economic damage to the swine industry worldwide. Despite the continued use of vaccines, PED outbreaks continue, highlighting the need to review the effectiveness of current vaccines and develop additional vaccines based on new platforms.

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This study aimed to measure masticatory performance (MP) using β-carotene gummy jelly to investigate its relationship with skeletal properties in decompensated patients diagnosed with skeletal class III malocclusion. The study included 78 patients (38 men and 40 women) diagnosed with skeletal class III malocclusion without temporomandibular joint disorder and periodontal disease. MP was measured using a new masticatory measuring device and β-carotene in the gummy jelly.

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Parkinson's disease (PD) is an incurable neurological disorder that causes typical motor deficits. In this study, we investigated the effects of creatine supplementation and exercise in the subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. We found that 2% creatine supplementation and/or exercise intervention for 4 weeks elicited neurobehavioral recovery and neuroprotective effects regarding dopaminergic cell loss in MPTP-treated mice; this effect implies functional preservation of dopaminergic cells in the substantia nigra, as reflected by tyrosine hydroxylase expression recovery.

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In this study, we selected materials that efficiently adsorb total hydrocarbons (THCs) from petrochemical storage facilities and applied four types of activated carbons to adsorb THCs to evaluate their properties. Four gases with low boiling points, namely, ethylene, ethane, propylene, and propane, generated via petrochemical storage facilities, were selected and mixed to a constant concentration with four types of materials and used to investigate the adsorption capacities and desorption properties. The adsorbents comprised two raw materials and two chemically activated materials.

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Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response. ATF4 regulates adaptive gene expression, thereby triggering stress resistance in cells.

Methods: To characterize the metabolic status of larvae, we conducted both metabolomic and microarray analyses.

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Article Synopsis
  • Racial and ethnic disparities exist in hepatitis C virus (HCV) treatment and survival rates for related liver cancer, with Black patients facing the worst outcomes.
  • In a study of 6,069 patients, treatment rates for direct-acting antiviral agents (DAA) were significantly lower for Black individuals (18.7%) compared to other racial groups, impacting their survival rates.
  • The study concluded that although DAA treatment rates were low overall, achieving sustained virologic response (SVR) eliminated racial disparities, highlighting the need for better early diagnosis and access to HCV treatment for all patients.
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Porcine epidemic diarrhea virus (PEDV) is a highly contagious enteric pathogen of swine. PEDV has been a major problem in the pig industry since its first identification in 1992. The aim of this study was to investigate the diversity, molecular characteristics, and phylogenetic relationships of PEDVs in field samples from Korea.

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Article Synopsis
  • Single-target rapid antigen tests (RATs) are used to detect respiratory viruses like SARS-CoV-2 and influenza, but there's limited research on tests that can detect multiple viruses simultaneously.
  • A study evaluated multiplex RATs for SARS-CoV-2 and influenza using 974 nasopharyngeal swab samples, focusing on their diagnostic performance and sensitivity.
  • The InstaView kit showed the highest detection rates and sensitivity for both SARS-CoV-2 and influenza A/B, making it the recommended option for routine screening in communities.
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This study aims to investigate the neuroprotective effects of nootkatone (NKT), a sesquiterpenoid compound isolated from grapefruit, in an MPTP-induced Parkinson's disease (PD) mouse model. NKT restored MPTP-induced motor impairment and dopaminergic neuronal loss and increased the expression of neurotrophic factors like BDNF, GDNF, and PGC-1α. In addition, NKT inhibited microglial and astrocyte activation and the expression of pro-inflammatory markers like iNOS, TNF-α, and IL-1β and oxidative stress markers like 4-HNE and 8-OHdG.

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Article Synopsis
  • * Changes in the gut microbiota and bile acid levels were observed in Shp mice, revealing a dysbiosis that influences metabolic disorders.
  • * Cohousing Shp mice with wild-type (WT) mice under a Western diet disrupted the Shp mice's microbiome benefits, indicating that gut bacteria play a significant role in the metabolic effects linked to Shp deletion.
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The health-beneficial outcomes of doenjang, a Korean fermented food have been questioned due to its high salt content; moreover, the detailed underlying mechanisms of its health beneficial effects are not fully investigated. Thus, this study aimed to investigate doenjang's anti-obesity effects, anti-hypertensive effects, and its underlying mechanisms in high-fat diet -induced obesity. Sprague-Dawley rats fed with normal diet (ND), high-fat diet (HD), HD with 8% additive salt (HDS), or HD with doenjang containing 8% salt (HDJ) for 13 weeks.

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Soy sauce (SS) is a traditional fermented seasoning. Although fermented foods have diverse health beneficial effects, SS intake has been discouraged because of its high salt level. This study was designed to evaluate the antiobesity outcomes of SS and the potential involvement of salt content in SS by adding a high-salt group.

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Synopsis of recent research by authors named "Jung-Eun Park"

  • - Jung-Eun Park's recent research encompasses a diverse range of topics related to infectious diseases, neuroinflammation, and metabolic disorders, reflecting a strong focus on understanding various pathophysiological mechanisms and therapeutic strategies.
  • - Notable findings include the development of a multiplex real-time PCR assay for simultaneous detection of multiple pathogens, insights into the role of specific bioactive compounds in mitigating neuroinflammation, and the impact of traditional fermented foods on hypertension and obesity.
  • - Park's work also investigates the molecular and immunological responses associated with viral infections and metabolic diseases, such as Alzheimer's and nonalcoholic fatty liver disease, highlighting potential avenues for innovative treatments and public health interventions.