Publications by authors named "Jung Vin Seo"
Article Synopsis
- Proteomic studies on postmortem human brain tissue have assessed the effects of aging and neurodegenerative diseases, particularly Alzheimer's, but identifying specific proteins that influence biological processes remains a challenge.
- A cross-platform analysis focused on synaptic processes in the entorhinal cortex was conducted, using mass spectrometry to identify 2260 proteins and correlate them with dendritic spine metrics.
- The study successfully pinpointed Twinfilin-2 (TWF2) as a key protein linked to spine length, and experimentally validated that enhancing TWF2 levels boosts thin spine growth in neurons, thus contributing to a deeper understanding of synaptic alterations in Alzheimer's.
Dendritic spines are small protrusions on dendrites that serve as the postsynaptic site of the majority of excitatory synapses. These structures are important for normal synaptic transmission, and alterations in their density and morphology have been documented in various disease states. Over 130 years ago, Ramón y Cajal used Golgi-stained tissue sections to study dendritic morphology.
View Article and Find Full Text PDFRho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial and temporal control of gene expression. To overcome this, we generated ROCK2 mice.
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