Clinical Trial Protocol for Porcine Islet Xenotransplantation in South Korea.

Backgruound: Islet transplantation holds promise for treating selected type 1 diabetes mellitus patients, yet the scarcity of human donor organs impedes widespread adoption. Porcine islets, deemed a viable alternative, recently demonstrated successful longterm survival without zoonotic risks in a clinically relevant pig-to-non-human primate islet transplantation model. This success prompted the development of a clinical trial protocol for porcine islet xenotransplantation in humans.

STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme.

Inactivating mutations of genes encoding the cohesin complex are common in a wide range of human cancers. STAG2 is the most commonly mutated subunit. Here we report the impact of stable correction of endogenous, naturally occurring STAG2 mutations on gene expression, 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme (GBM).

The effect of cognitive behavioral therapy on depression of people with epilepsy.

Background: Depression, a common mental problem frequently detected in people with epilepsy (PWE), is a major factor that decreases the quality of life of PWE. The cognitive behavioral therapy (CBT) is the most commonly used non-pharmacological treatment for depressive disorders. The CBT for PWE with depression has not yet been studied in Korea.

Identification of STAG2-Mutant Bladder Cancers by Immunohistochemistry.

Bladder cancer is the fifth most common cancer in the United States. Most bladder cancers are early-stage lesions confined to the mucosa or submucosa and are therefore classified as non-muscle-invasive bladder cancer (NMIBC). A minority of tumors are diagnosed after they have invaded the underlying detrusor muscle and are classified as muscle-invasive bladder cancer (MIBC).

Long-term oncologic outcome of D3 lymph node dissection for clinical stage 2/3 right-sided colon cancer.

Purpose: To investigate oncologic outcomes including overall survival and disease-free survival depending on the extent of lymphadenectomy (D3 versus D2) by comparing D3 and D2 lymphadenectomy in patients with clinical stage 2/3 right colon cancer.

Methods: Consecutive series of patients who underwent radical resection for right colon cancer at our three hospitals between January 2015 and June 2018 were retrospectively analyzed. Study cohorts were divided into two groups: D3 group and D2 group.

Tuning LaO to high ionic conductivity by Ni-doping.

Ni-doped LaO was developed as an ionic conducting membrane corresponding to a conductivity of 0.187 S cm at 550 °C. A peak power density of 970 mW cm with an open circuit voltage of 1.

Surface-Engineered Homostructure for Enhancing Proton Transport.

Ultra-wide bandgap semiconductor samarium oxide attracts great interest because of its high stability and electronic properties. However, the ionic transport properties of Sm O have rarely been studied. In this work, Ni doping is proposed to be used for electronic structure engineering of Sm O .

Multimaterial Self-Aligned Nanopatterning by Simultaneous Adjacent Thin Film Deposition and Etching.

Printed component sizes in electronic circuits are approaching 10 nm, but inherent variability in feature alignment during photolithography poses a fundamental barrier for continued device scaling. Deposition-based self-aligned patterning is being introduced, but nuclei defects remain an overarching problem. This work introduces low-temperature chemically self-aligned film growth simultaneous thin film deposition and etching in adjacent regions on a nanopatterned surface.

Acetyl-CoA carboxylase-1/2 blockade locks dendritic cells in the semimature state associated with FA deprivation by favoring FAO.

Immunometabolism is rising as an intriguing topic that reveals the connection between immune cell function and metabolic processes. Especially, fatty acid metabolism plays an essential role in the dendritic cells (DCs) during the differentiation and maturation period. We questioned whether regulation of acetyl-CoA carboxylases 1 and 2-(ACC1/2), the core enzymes of fatty acid synthesis (FAS), would control DC function.

Impact of D3 lymph node dissection on upstaging and short-term survival in clinical stage I right-sided colon cancer.

Background: D3 lymph node dissection is becoming the standard procedure for the treatment of advanced right colon cancer and has shown increasing evidence of its oncologic benefit. However, a clear indication for its application is lacking and data on this topic is unsatisfactory. Thus, the necessity for D3 lymph node dissection in clinical stage I right colon cancer remains controversial.

Photocatalytic Reaction Properties of TiO₂-Supported on the Long Lasting Phosphor: Sr₄AlO:Eu,Dy.

The TiO₂/Sr4AlO25:Eu,Dy photocatalytic composite was prepared by depositing the nano-crystalline titanium dioxide layer on the long-lasting phosphor substrate of strontium aluminate, using a low-pressure chemical vapor deposition (LP-CVD). The photocatalysis characteristic was studied by examining the photodegradation of benzene (CH) gas under UV, visible light illumination, and in the darkness. The photocatalytic composite of TiO₂-deposited Sr₄AlO:Eu,Dy showed an active photocatalytic reactivity under UV-light as well as visible-light illumination.

STAG2 as a prognostic biomarker in low-grade non-muscle invasive bladder cancer.

Objective: Improvements to bladder cancer risk stratification guidelines are needed to better tailor post-operative surveillance and adjuvant therapy to individual patients. We previously identified STAG2 as a commonly mutated tumor suppressor gene in bladder cancer and an independent predictor of progression in NMIBC. Here we test the value of combining STAG2 immunostaining with other risk stratification biomarkers in NMIBC, and as an individual biomarker in MIBC.

Junction and energy band on novel semiconductor-based fuel cells.

Fuel cells are highly efficient and green power sources. The typical membrane electrode assembly is necessary for common electrochemical devices. Recent research and development in solid oxide fuel cells have opened up many new opportunities based on the semiconductor or its heterostructure materials.

USP13 interacts with cohesin and regulates its ubiquitination in human cells.

Cohesin is a multiprotein ring complex that regulates 3D genome organization, sister chromatid cohesion, gene expression, and DNA repair. Cohesin is known to be ubiquitinated, although the mechanism, regulation, and effects of cohesin ubiquitination remain poorly defined. We previously used gene editing to introduce a dual epitope tag into the endogenous allele of each of 11 known components of cohesin in human HCT116 cells.

Effect of Coupling Indium Tin Oxide with the TiO₂-NaYF₄:(Gd, Si) Composite for Photocatalytic Properties.

Indium tin oxide (ITO) nanoparticles were coupled with NaYF4:(Gd, Si) using a TiO₂-solution impregnation method. Scanning electron microscopy confirmed that TiO₂ and ITO nanoparticles were loaded on the surface of the NaYF4:(Gd, Si) upconversion phosphor. The ultraviolet/visible spectra of the 20 wt.

Development of a Novel Multi-Channel Thermocouple Array Sensor for In-Situ Monitoring of Ice Accretion.

A test was performed to determine the efficacy of a novel multi-channel thermocouple temperature sensor employing "" array architecture for the in-situ detection of icing in cold climates. T-type thermoelements were used to fabricate a sensor with six independent temperature sensing points, capable of two-dimensional temperature mapping. The sensor was intended to detect the high latent heat of fusion of water (334 J/g) which is released to the environment during ice formation.

Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation.

Clinical islet transplantation has recently been a promising treatment option for intractable type 1 diabetes patients. Although early graft loss has been well studied and controlled, the mechanisms of late graft loss largely remains obscure. Since long-term islet graft survival had not been achieved in islet xenotransplantation, it has been impossible to explore the mechanism of late islet graft loss.

CD4 /CD8 T-cell ratio correlates with the graft fate in pig-to-non-human primate islet xenotransplantation.

Background: Xenogeneic islet transplantation using porcine pancreata has been a promising option for substituting human islet transplantation. Moreover, recent advances in pre-clinical results have put islet xenotransplantation closer to the possibility of clinical application. While preparing for the era of clinical xenotransplantation, developing non-invasive immune monitoring method which could predict the graft fate could benefit the patient.

Spring Based Connection of External Wires to a Thin Film Temperature Sensor Integrated Inside a Solid Oxide Fuel Cell.

Thermal management of SOFCs (solid oxide fuel cell) is important for helping to minimise high temperature-related performance losses and maximising cell/stack lifetime. Thin film sensor technology is proposed as an excellent candidate to measure the cell temperature during operation due to its negligible mass, minimal disturbance to normal operation and higher temporal and spatial resolutions. However, the effective application of such sensors in SOFC systems is a challenging endeavour and predicated on incorporating the external wire attachments to complete the electrical circuit.

Preparation and Characterization of Bimetallic Fe-Ni Oxide Nanoparticles Using Liquid Phase Plasma Process.

The Fe-Ni oxide bimetallic nanoparticles (FNOBNPs) were synthesized in the liquid phase plasma (LPP) method employed an iron chloride and nickel chloride as metal precursors. The sphericalshaped FNOBNPs were synthesized by the LPP process and, the size of particles was growing along with the progression of LPP reaction. The synthesized FNOBNPs were comprised of Fe₃O₄ and NiO.

Degradation of dimethyl phthalate using a liquid phase plasma process with TiO photocatalysts.

The liquid phase plasma (LPP) method with a TiO photocatalyst and hydrogen peroxide was used to decompose dimethyl phthalate (DMP). As the applied voltage, pulse width, and frequency were increased, the rate of decomposition was increased and the decomposition rate was 63% for 180 min under plasma optimum conditions. The addition of TiO photocatalyst and hydrogen peroxide increased the DMP decomposition reaction rate, but an excess cause a decrease in decomposition rate due to a decrease in conductivity, blocking of ultraviolet light, and scavenger effect.

Advanced Fuel Cell Based on Perovskite La-SrTiO Semiconductor as the Electrolyte with Superoxide-Ion Conduction.

A solid oxide fuel cell's performance is largely determined by the ionic-conducting electrolyte. A novel approach is presented for using the semiconductor perovskite LaSrTiO (LST) as the electrolyte by creating surface superionic conduction, and the authors show that the LST electrolyte can deliver superior power density, 908.2 mW cm at just 550 °C.