Publications by authors named "Jung Seop Eom"

Introduction: Guideline-discordant low-dose computed tomography (LDCT) screening may cause lung cancer (LC) overdiagnosis, but its extent and consequences are unclear. This study aimed to investigate the prevalence of self-initiated, non-reimbursed LDCT screening in a predominantly non-smoking population and its impact on LC epidemiology and healthcare utilization.

Methods: This nationwide cohort study analyzed data from Korea's National Health Information Database (NHID) and eleven academic hospital screening centers (1999-2022).

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Background: Molecular screening using next-generation sequencing (NGS) in the pathologic evaluation of lung cancer is considered the standard in clinical practice; hence, we evaluated the diagnostic yields of various sampling methods for NGS.

Methods: NGS data from patients with lung cancer at the Pusan National University Hospital (Busan, South Korea), admitted October, 2020-April, 2023, was obtained. The sampling methods by which NGS data was obtained were divided into surgical and nonsurgical.

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Article Synopsis
  • The study investigated the effectiveness of patient-performed rapid antigen tests (RATs) in detecting COVID-19 variants Delta and Omicron during the pandemic, particularly in self-testing scenarios in Korea.
  • Researchers conducted a multicenter clinical study involving participants without prior diagnostic experience and compared RAT results with the more accurate reverse transcriptase-polymerase chain reaction (RT-PCR) testing.
  • Results showed that RATs were better at detecting the Omicron variant, while their performance for Delta was lower, especially among those who were only partially vaccinated, highlighting the need for careful use of these tests in different vaccination contexts.
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  • The study investigates the effects of durvalumab consolidation therapy on patients with non-small cell lung cancer (NSCLC) who have either mutant (EGFR M+) or wild-type (EGFR M-) epidermal growth factor receptors, specifically looking at programmed death-ligand 1 (PD-L1) expression levels.
  • Of the 249 unresectable stage III NSCLC patients treated, only 12.4% had EGFR M+, with the median progression-free survival (PFS) being significantly longer in patients with high PD-L1 expression (≥50%) compared to those with EGFR M+ and low PD-L1 expression.
  • The findings suggest that durvalumab can be beneficial for EGFR M+
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Purpose: Invasive mucinous adenocarcinoma (IMA) of the lungs is a rare subtype of lung adenocarcinoma with a limited understanding of its prognosis, particularly in advanced stages. This study aimed to assess the prognosis of patients with advanced IMA by focusing on treatment modalities.

Methods: This single-center retrospective study evaluated 33 patients with IMAs diagnosed with advanced-stage disease or disease progression after curative treatment between 2011 and 2021.

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Purpose: The use of neoadjuvant anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (TKIs) has not been extensively explored. The current case report highlights the notable pathological complete response (pCR) achieved following neoadjuvant brigatinib therapy in a patient with stage IIIA ALK-positive non-small cell lung cancer (NSCLC).

Case Presentation: A 32-year-old male presented with incidental lung lesions, ultimately diagnosed as clinical stage T3N1M0, IIIA NSCLC with an gene rearrangement.

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Background: International guidelines recommend the use of local therapy (LT) to limited progression in patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC). However, the use of LT before disease progression has not been extensively analyzed. This meta-analysis evaluates the efficacy and safety of administering additional LT in conjunction with first-line EGFR-tyrosine kinase inhibitors (TKIs) before disease progression in patients with EGFR-mutated advanced NSCLC.

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In cases where pulmonary tuberculosis (PTB) is not microbiologically diagnosed via sputum specimens, bronchoscopy has been the conventional method to enhance diagnostic rates. Although the additional benefit of bronchoscopy in diagnosing PTB is well-known, its overall effectiveness remains suboptimal. This review introduces several strategies for improving PTB diagnosis via bronchoscopy.

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Article Synopsis
  • The PACIFIC trial showed that durvalumab improves survival for certain lung cancer patients, but there’s limited data on its effectiveness in those aged 70 and older.
  • A retrospective study analyzed 286 patients, revealing similar progression-free survival (PFS) and overall survival (OS) between elderly and younger groups, yet elderly patients had a lower completion rate of durvalumab.
  • Elderly patients experienced more adverse events (AEs), especially pulmonary issues, suggesting the need for careful patient selection and monitoring when treating older patients with durvalumab.
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Background: The modified NUTRIC (nutritional risk in the critically ill) score has been reported to predict clinical outcomes in critically ill patients. However, the applicability of this score may differ between patients undergoing short-term mechanical ventilation (STMV, < 96 h) and those undergoing prolonged acute mechanical ventilation (PAMV, ⩾96 h), as PAMV patients typically experience significantly higher morbidity and mortality.

Objective: This study aimed to investigate the predictive ability of modified NUTRIC score for predicting 28-day mortality in patients receiving STMV and PAMV.

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: This study aimed to assess the value of a novel prognostic model, based on clinical variables, comorbidities, and demographic characteristics, to predict long-term prognosis in patients who received mechanical ventilation (MV) for over 14 days and who underwent a tracheostomy during the first 14 days of MV. : Data were obtained from 278 patients (66.2% male; median age: 71 years) who underwent a tracheostomy within the first 14 days of MV from February 2011 to February 2021.

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Background And Objective: Next-generation sequencing (NGS) analysis is considered standard for lung cancer diagnosis in clinical practice. Little is known about the feasibility of NGS using tumour tissue sampled with a 1.1 mm-diameter cryoprobe.

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Purpose: Radial probe endobronchial ultrasound (RP-EBUS) accurately locates peripheral lung lesions (PLLs) during transbronchial biopsy (TBB). We performed an updated meta-analysis of the diagnostic yield of TBB for PLLs using RP-EBUS to generate recommendations for the development of the Korean Association of Lung Cancer guidelines.

Materials And Methods: We systematically searched MEDLINE and EMBASE (from January 2013 to December 2022), and performed a meta-analysis using R software.

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Article Synopsis
  • Targeted therapy and immunotherapy, initially developed for advanced non-small cell lung cancer (NSCLC), are now being explored for early-stage cases in the adjuvant setting.
  • Recent approvals include osimertinib for specific tumors and atezolizumab and pembrolizumab for certain patients with resectable NSCLC.
  • Ongoing studies aim to determine the best strategies for these treatments, though many questions about their optimal use in the adjuvant phase remain.
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Objectives: Transbronchial cryobiopsy (TBCB) is a novel technique for the diagnosis of peripheral lung lesions (PLLs). We aim to evaluate the clinical outcomes of TBCB using a new 1.1-mm diameter cryoprobe for the diagnosis of PLLs.

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mutational status in resected non-small cell lung cancer (NSCLC) in the Korean population is poorly understood. We explored (particularly V600E) mutational status among Korean patients with NSCLC. : This study included 378 patients with resected primary NSCLC who were enrolled from January 2015 to December 2017.

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Since the introduction of low-dose computed tomography (CT) screening for patients at high risk of lung cancer, the detection rate of suspicious lung cancer has increased. In addition, there have been many advances in therapeutics targeting oncogenic drivers in non-small cell lung cancer. Therefore, accurate pathological diagnosis of lung cancer, including molecular diagnosis, is increasingly important.

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Purpose: Epidermal growth factor receptor (EGFR) T790M mutations have been detected in the second or third rebiopsy, even if the T790M mutation was not identified in the first rebiopsy. This meta-analysis investigated the EGFR T790M mutation detection rates and its additional advantages with repeated rebiopsies.

Materials And Methods: We searched through the PubMed and EMBASE databases up to June 2022.

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Background: The present study evaluated the association between participation in a rehabilitation program during a hospital stay and 1-year survival of patients requiring at least 21 days of mechanical ventilation (prolonged mechanical ventilation [PMV]) with various respiratory diseases as their main diagnoses that led to mechanical ventilation.

Methods: Retrospective data of 105 patients (71.4% male, mean age 70.

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Background: Detection of the epidermal growth factor receptor (EGFR) T790M mutation using plasma samples has been considered simple and non-invasive, but the relatively high false negative results lead to additional tissue sampling in some patients. Until now, the characteristics of patients who prefer liquid biopsy have not yet been established.

Methods: To evaluate the favorable conditions for the detection of T790M mutations using plasma samples, a multicenter retrospective study was performed between May 2018 and December 2021.

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Background/aims: Despite the obvious benefits of adding immune checkpoint inhibitors to platinum-etoposide chemotherapy in patients with extensive-stage small-cell lung cancer (ES-SCLC), real-world data remain scarce.

Methods: This retrospective study included 89 patients with ES-SCLC treated with platinum-etoposide chemotherapy alone (chemo-only group; n = 48) or in combination with atezolizumab (atezolizumab group; n = 41) and compared the survival outcomes between these two groups.

Results: Overall survival (OS) was significantly longer in the atezolizumab group than in the chemo-only group (15.

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Objective: For thoracoscopy, the usefulness of a dye mixture of indigo carmine and Lipiodol for localizing lung lesions has been reported. However, little is known about the stability and safety of this dye mixture injected on the visceral pleura through a bronchoscope.

Methods: Porcine models were divided into three groups according to the detection time of the dye mixture: group A with a detection time of 4 h; group B, 8 h; and group C, 24 h.

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Background: Although almost all interventional pulmonologists agree that rigid bronchoscopy is irreplaceable in the field of interventional pulmonology, less is known about the types of diseases that the procedure is used for and what difficulties the operators face during the procedure. The purpose of this study is to evaluate what diseases rigid bronchoscopy is used for, whether it is widely used, and what challenges the operators face in Korea.

Methods: We enrolled 14 hospitals in this retrospective cohort of patients who underwent rigid bronchoscopy between 2003 and 2020.

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Background: Ultrathin bronchoscopy (external diameter, ≤3.5 mm) is useful for the diagnosis of peripheral pulmonary lesions because of its good accessibility.

Objectives: We performed a meta-analysis to investigate the diagnostic yield of ultrathin bronchoscopy for peripheral pulmonary lesions.

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Article Synopsis
  • - The study evaluated the effectiveness and safety of sequential transbronchial cryobiopsy (TBC) combined with traditional transbronchial biopsy (TBB) using radial probe endobronchial ultrasound (RP-EBUS) for diagnosing small peripheral lung lesions (PLLs).
  • - Results showed that combining TBB and TBC increased the diagnostic yield to 79.1%, compared to 60.9% for TBB alone, with TBC contributing an 18.2% increase.
  • - The TBC technique provided larger tissue samples and had a low complication rate (10.5%), indicating it is a safe and effective method for improving diagnostic outcomes in patients with PLLs.
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