Publications by authors named "Jung Jae Woo"
Spinal cord injury (SCI) remains a significant clinical challenge, with no fully effective treatment available despite advancements in various therapeutic approaches. This review examines the emerging role of induced neural stem cells (iNSCs) as promising candidates for SCI treatment, highlighting their potential for direct neural regeneration and integration with host tissue. We explore the biology of iNSCs, their mechanisms of action, and their interactions with host tissue, including modulating inflammatory responses, promoting axonal growth, and reconstructing neural circuits.
View Article and Find Full Text PDFBackground: Limited understanding exists regarding the progression trajectory of severe eosinophilic asthma (SEA) patients on type 2 biologics therapies.
Objective: We aim to explore distinct longitudinal phenotypes of these patients based on crucial asthma biomarkers.
Methods: We enrolled 101 adult patients with SEA.
Purpose: Despite the emerging biologics, biomarkers and treatment options for asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) are still limited, requiring further research.
Methods: We enrolled 378 ACO patients from a multicenter real-world asthma cohort in Korea and compared the clinical characteristics, lung function, and exacerbation between type 2 (T2)-high and T2-low groups. We used the following comparisons: 1) low vs.
Article Synopsis
- Allergens, like dust or pet dander, can make people allergic, and in Korea, about 45% of people are sensitized to them.
- The study tested over 2,300 people to see how allergic reactions relate to age and found different patterns for young people and older adults.
- People who are sensitized to allergens have higher chances of getting allergic conditions like skin rashes and sinus issues.
The objective of this study is to investigate the effect of nano-plastics (NPs) on the growth, photosynthesis, oxidative stress and antioxidant enzymes in Grateloupia turuturu and Chondrus ocellatus. Difference of surface characteristics between G. turuturu and C.
View Article and Find Full Text PDFBackground: Anti-type 2 (T2) biologic therapies (biologics) improve exacerbation rates, lung function, and asthma-related quality of life (QoL) in patients with severe T2 asthma. However, studies comparing different biologics are lacking. We evaluated the QoL in patients with severe asthma comprehensively and compare the efficacy of different T2-directed biologics using QoL questionnaires.
View Article and Find Full Text PDFBackground: Lichens, traditionally considered as a simple partnership primarily between mycobiont and photobiont, are, in reality, complex holobionts comprised of a multitude of microorganisms. Lichen mycobiome represents fungal community residing within lichen thalli. While it is acknowledged that factors like the host lichen species and environmental conditions influence the structure of the lichen mycobiome, the existing research remains insufficient.
View Article and Find Full Text PDFPurpose: Severe asthma is associated with high morbidity and healthcare utilization; however, treatment options for these patients are limited. This study aimed to determine the therapeutic effects of biologics in clinical practice.
Methods: This multicenter, retrospective cohort study included 136 patients who received biologics for at least 4 months between September 2017 and July 2022 at 25 medical centers affiliated with the Korean Severe Asthma Registry (KoSAR).
Article Synopsis
- Heart failure is a big problem because heart cells called cardiomyocytes (CMs) die and can’t regenerate well.
- Researchers, like Ji and their team, have found a new way to help heart cells regenerate by affecting certain signals in these cells and another type of heart cell called cardiac fibroblasts (CFs).
- This new approach could lead to exciting new treatments for heart problems in the future.
Eosinophilia Is a Favorable Marker for Pneumonia in Chronic Obstructive Pulmonary Disease.
Tuberc Respir Dis (Seoul)
October 2024
Background: Patients with chronic obstructive pulmonary disease (COPD) expressing eosinophilia experience slightly fewer episodes of community-acquired pneumonia (CAP), than those without eosinophilia. However, the severity and burden of hospitalized pneumonia patients with COPD involving eosinophilia have not been assessed.
Methods: We evaluated the differences in clinical characteristics between patients with CAP and COPD with or without eosinophilia by a post hoc analysis of a prospective, multi-center, cohort study data.
Article Synopsis
- Eczema and contact dermatitis are common but can significantly impact quality of life; this study explores the effects of bee venom acupuncture (BVA) and herbal medicine (San Wu Huangqin decoction; SWH) as a combination treatment.
- Case studies of two patients (one female, one male) showed that a three-month treatment with BVA and SWH led to the healing of their hand eczema and contact dermatitis, with no recurrence after one and three years.
- Additionally, animal tests demonstrated that this combination therapy improved clinical symptoms and decreased inflammation related to eczema-like dermatitis in mice, suggesting it could be a viable alternative treatment for these conditions.
Background: Hypersensitivity pneumonitis (HP) is a condition with an uncertain global incidence, and information on its diagnosis and management is limited. This study aimed to address these knowledge gaps.
Methods: This study utilized customized claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea from January 2010, to December 2021.
Background: Handgrip strength (HGS) is acknowledged as a key indicator of overall physical fitness and is associated with various health outcomes.
Objectives: This research investigates the correlation between HGS and quality of life (QoL), focusing on its relation to pulmonary function in the general adult population.
Method: The study involved 19,402 participants aged 40 and above, spanning from 2014 to 2019, who underwent pulmonary function and HGS tests.
Background: The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asthma (SEA) on biological treatment (BioT) remain elusive.
Objective: We sought to identify the predictors of early and late lung function improvement in patients with SEA after BioT.
Methods: 140 adult patients with SEA who received mepolizumab, dupilumab, or reslizumab were followed up for 6 months to evaluate improvement in forced expiratory volume in one second (FEV).
Background: Transmembrane 4 L six family member 5 (TM4SF5) translocates subcellularly and functions metabolically, although it is unclear how intracellular TM4SF5 translocation is linked to metabolic contexts. It is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of metabolisms.
Methods: Here, we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites (MLCSs), using in vitro cells and in vivo animal systems, via approaches by immunofluorescence, proximity labelling based proteomics analysis, organelle reconstitution etc.
Background: Despite the increasing use of biologics in severe asthma, there is limited research on their use in asthma-chronic obstructive pulmonary disease overlap (ACO). We compared real-world treatment responses to biologics in ACO and asthma.
Methods: We conducted a multicenter, retrospective, cohort study using data from the Precision Medicine Intervention in Severe Asthma (PRISM).
Background/aims: Chronic obstructive pulmonary disease (COPD) is less prevalent in females than males, but it affects mortality in females. There may be sex differences in the clinical characteristics of COPD.
Methods: We analyzed the Korea National Health and Nutrition Examination Survey dataset from 2007 to 2018.
Article Synopsis
- A study was conducted to compare the effectiveness of three monoclonal antibodies—reslizumab, mepolizumab, and dupilumab—in treating severe eosinophilic asthma (SEA).
- The analysis involved 141 SEA patients, looking at exacerbation rates, lung function, and asthma control over 12 months.
- Results indicated that all three treatments led to similar clinical outcomes, with no significant differences between the drugs in managing asthma exacerbations and overall control.
Article Synopsis
- A study assessed the best strategies to prevent hypersensitivity reactions (HSR) in patients with a history of immediate HSR to low-osmolar iodinated contrast media (LOCM), examining factors like premedication and LOCM substitutions.
- The research included 3800 LOCM exposures in 1066 patients, finding that premedication with corticosteroids significantly reduced the chance of HSR recurrence, while using different LOCM without common side chains was notably effective.
- The results emphasized that switching to alternative LOCM, especially those without shared side chains, significantly decreased HSR occurrences, particularly in patients who previously had moderate to severe reactions.
Background: Lichens are symbiotic organisms composed of a fungus and a photosynthetic partner, which are key ecological bioindicators due to their sensitivity to environmental changes. The endolichenic fungi (ELF) living inside lichen thalli, are an important but understudied component of playing crucial ecological roles such as nutrient cycling and protection against environmental stressors. Therefore ELF community investigation is vital for fostering sustainable ecosystems and leveraging their ecological benefits.
View Article and Find Full Text PDFArticle Synopsis
- Lichens are made up of fungi and tiny plants that work together, and they also have other fungi living inside them called endolichenic fungi, which help the lichen survive in different ways.
- Researchers studied two types of lichens and found out that the endolichenic fungi are less diverse and different from the fungi that live on the bark of trees nearby.
- The endolichenic fungi have a simpler structure compared to the surrounding fungi, which helps scientists understand how these tiny ecosystems work.
Background/aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the serotype specificity of Streptococcus pneumoniae have not been evaluated in the post-era of pneumococcal vaccination in Korea.
Methods: We conducted a prospective, multi-center, cohort study from seven University-affiliated hospitals.
Plastics are the most abundant marine litter in the world's oceans and can be degraded into micro-plastics. These emerging pollutants negatively affect marine organisms, but little is known on the effects on macroalgae. In this study, we investigated the effects of micro-plastics on two species of red algae: Grateloupia turuturu and Chondrus sp.
View Article and Find Full Text PDFArticle Synopsis
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Introduction: With the availability of retrospective pharmacovigilance data, the common data model (CDM) has been identified as an efficient approach towards anonymized multicenter analysis; however, the establishment of a suitable model for individual medical systems and applications supporting their analysis is a challenge.
Objective: The aim of this study was to construct a specialized Korean CDM (K-CDM) for pharmacovigilance systems based on a clinical scenario to detect adverse drug reactions (ADRs).
Methods: De-identified patient records (n = 5,402,129) from 13 institutions were converted to the K-CDM.