Publications by authors named "Jung Jae Jo"
Article Synopsis
- Ginseng, particularly Korean red ginseng (KRG), is widely used as an herbal remedy, but its long-term effects on liver health are under-researched.
- A study using mouse models found that high doses (1.0 and 2.0 g/kg) of KRG led to liver injury markers and elevated glucose levels.
- The research identified increased levels of liver proteins responsible for hydrogen sulfide production, suggesting that KRG may influence liver function negatively with prolonged use.
Ginseng (Panax ginseng Meyer) is a popular traditional herbal medicine used worldwide. Patients often take ginseng preparations with other medicines where the ginseng dose could exceed the recommended dose during long-term administration. However, ginseng-drug interactions at high doses of ginseng are poorly understood.
View Article and Find Full Text PDFThe author would like to change conflict of interest statement of the online published article.
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- - Non-alcoholic fatty liver disease (NAFLD) includes various liver conditions like steatosis and can lead to serious issues, but its impact on drug metabolism, specifically via cytochrome P450 enzymes, is not well understood.
- - Researchers used a methionine-choline deficient diet to induce NAFLD in study subjects and employed advanced methods to analyze over 1,200 hepatic proteins, finding significant changes in their levels.
- - The study revealed that many cytochrome P450 enzymes were down-regulated in NAFLD, affecting drug metabolism, but CYP2D levels remained stable, highlighting the complex interactions between liver health and drug processing.
Leelamine is a diterpene compound found in the bark of pine trees and has garnered considerable interest owing to its potent anticancer properties. The aim of the present study was to investigate the metabolic profile of leelamine in human liver microsomes (HLMs) and mice using liquid chromatography-tandem mass spectrometry (LC-MS/MS). We found that leelamine undergoes only Phase I metabolism, which generates one metabolite that is mono-hydroxylated at the C9 carbon of the octahydrophenanthrene ring (M1) both in vitro and in vivo.
View Article and Find Full Text PDFCocktail substrates are useful in investigating drug-drug interactions (DDI) that can rapidly identify the cytochrome P450 (CYP) isoforms that interact with test drugs. In this study, we developed and validated five probe drugs for CYP1A, CYP2B, CYP2C, CYP2D, and CYP3A using LC-MS/MS to determine CYP activities in mice. The five probe substrates were caffeine (2 mg/kg), bupropion (30 mg/kg), omeprazole (4 mg/kg), dextromethorphan (40 mg/kg), and midazolam (2 mg/kg) for CYP1A, CYP2B, CYP2C, CYP2D, and CYP3A, respectively.
View Article and Find Full Text PDFTuberculosis is one of the top causes of death among curable infectious diseases; it is an airborne infectious disease that killed 1.1 million people worldwide in 2010. Anti-tuberculosis drug-induced liver injury is the primary cause of drug-induced liver injury (DILI).
View Article and Find Full Text PDFIdentification of absolute conversion to geraldol from fisetin and pharmacokinetics in mouse.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2016
Fisetin (3,3',4',7-tetrahydroxyflavone) is a flavonoid found in several fruits, vegetables, nuts, and wine and has anti-oxidant, anti-inflammatory, and anti-angiogenic properties. Geraldol is the 3'-methoxylated metabolite of fisetin (3,4',7-trihydroxy-3'-methoxyflavone). The concentration of fisetin and geraldol in mouse plasma was determined by LC-MS/MS, following direct protein precipitation.
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