The Efficacy of CT-Based Conformal Electron Beam Radiation Therapy After Keloid Excision.

Background: Adjuvant computed tomography-based conformal electron beam radiation therapy (RT) for patients with keloids enables radiation oncologists to customize the target volume with precision and deliver the maximal prescription dose while sparing normal surrounding tissues.

Objective: To report treatment and cosmetic outcomes by the patient's self-assessment survey.

Methods: Medical records of patients with keloids, who were treated with postoperative electron beam RT between January 2015 and December 2020, were reviewed.

Probiotic treatment induced change of inflammation related metabolites in IBS-D patients/double-blind, randomized, placebo-controlled trial.

There have been many studies suggesting that probiotics are effective in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). However, its mechanism of action as well as prediction of response is still to be elucidated. In the present study, to find out metabolomic characteristics of probiotic effect in IBS-D, we compared IBS symptom changes and metabolomic characteristics in the subjects' urine samples between multi-strain probiotics (one strain of sp.

Statins and metachronous recurrence after endoscopic resection of early gastric cancer: a nationwide Korean cohort study.

Background: Statins have shown to reduce the risk of various cancers. However, their effects on metachronous recurrence (MR) after endoscopic resection (ER) for early gastric cancer (EGC) are unknown. We evaluate their effects on MR development after ER for EGC.

Eradication Can Reverse the Methylation-Associated Regulation of in Gastric Carcinogenesis.

Background/aims: Epigenetic change is one of the mechanisms that regulates the expression of microRNAs (miRNAs) and is known to play a role in Helicobacter pylori-associated gastric carcinogenesis. We aimed to evaluate the epigenetic changes of in -associated gastric carcinogenesis and restoration after eradication.

Methods: The expression and methylation levels of were evaluated in gastric cancer (GC) cell lines, human gastric mucosa of -negative and -positive controls, and positive GC patients.

Clinical outcomes of early gastric cancer with non-curative resection after pathological evaluation based on the expanded criteria.

Additional surgical resection should be considered for the patients with pathological findings beyond the expanded criteria with the risk for LN metastasis. However, close observation without additional surgery may be applied because of various reasons. We aimed to determine the clinical outcomes of early gastric cancer beyond the expanded criteria after endoscopic resection according to the pathological extent.

Determining the current indications for endoscopic submucosal dissection in patients with Lauren mixed-type early gastric cancer.

Background And Aim: Recent study showed that early gastric cancer (EGC) with Lauren mixed-type (MT) histology is associated with worse prognosis. We aimed to evaluate the clinicopathologic features and prognostic significance of Lauren MT-EGCs that meets the criteria for endoscopic submucosal dissection (ESD).

Methods: We reviewed 2665 patients with EGC who underwent surgery between 2010 and 2015.

Synergistic Effect of Lymphatic Invasion and Venous Invasion on the Risk of Lymph Node Metastasis in Patients with Non-Curative Endoscopic Resection of Early Gastric Cancer.

Background: Although additive radical surgery is recommended for patients with non-curative endoscopic resection for early gastric cancer (EGC), lymph node (LN) metastasis or remnant tumor is detected in only about 10% of patients. Therefore, we aimed to identify patients who required surgery by identifying significant risk factors for LN metastasis and evaluate long-term outcomes in patients with non-curative endoscopic resection.

Methods: We retrospectively analyzed the database of Seoul National University Hospital to identify patients who underwent endoscopic resection for EGC from June 2005 to December 2016.

There might be a distinctive clinical phenotype of constipation with non-cardiac chest pain which responds to combination laxatives: A retrospective, longitudinal symptom analysis.

Proton pump inhibitor (PPI)-refractory non-cardiac chest pain (NCCP) is often resolved when constipation was relieved. This study aimed to investigate the clinical features of patients with both NCCP and constipated functional bowel disorders (FBD).Among 692 consecutive patients diagnosed with functional constipation or irritable bowel syndrome with constipation and underwent anorectal manometry (ARM) in our hospital, PPI-refractory NCCP was present in 37.

Exploring the possibility of endoscopic submucosal dissection for clinical submucosal invasive early gastric cancers.

Background: The current standard treatment modality for clinical submucosal invasive (cT1b) early gastric cancer (EGC) is surgery. However, there are discrepancies in T staging between pre- and post-operative findings, and in cases of overestimation, patients may lose the opportunity to preserve the stomach. The aim of this study was to analyze surgical outcomes of cT1b EGC and determine the pre-treatment factors favoring ESD.

Asthma under control is inversely related with erosive esophagitis among healthy adults.

Background: Some recent studies suggested that reflux esophagitis is positively correlated with asthma. However, there are debates on this issue. The aim of this study is to clarify the true association between reflux esophagitis and asthma in a large population.

Clinical features and outcomes in spontaneous intramural small bowel hematoma: Cohort study and literature review.

Background/aims: Spontaneous intramural small bowel hematoma (SISBH) is an extremely rare complication of anticoagulant or antiplatelet therapy. We assessed the clinical characteristics and outcomes of patients with SISBH according to the anatomical location of the hematoma.

Methods: From January 2003 to February 2016, medical records for all patients hospitalized for SISBH at 2 tertiary referral hospitals were retrospectively reviewed.

Clinical Implication and Risk Factors for Malignancy of Atypical Gastric Gland during Forceps Biopsy.

Background/aims: Although forceps biopsy is performed for suspicious gastric tumors during endoscopy, it is difficult to determine treatment strategies for atypical gastric glands due to uncertainty of the diagnosis. The aim of this study was to investigate clinical implications and risk factors for predicting malignancy in atypical gastric glands during forceps biopsy.

Methods: We retrospectively reviewed medical records of 252 patients with a diagnosis of atypical gastric gland during forceps biopsy.

Effects of Helicobacter pylori eradication for metachronous gastric cancer prevention: a randomized controlled trial.

Background And Aims: Whether eradication of Helicobacter pylori reduces the incidence of metachronous gastric cancer (MGC) is still debatable. We aimed to evaluate the long-term effect of H pylori eradication on the development of MGC after endoscopic gastric tumor resection.

Methods: We undertook an open-label, prospective, randomized controlled trial at a tertiary hospital in Seoul, Korea.

Seasonal changes in surface ozone over South Korea.

Recently, the surface ozone concentration in the Korean peninsula has been increasing more rapidly than in the past, and seasonal changes are appearing such as increases in the number of ozone alerts in springtime. We examined changes in the timing of annual maximum South Korean O levels by fitting a sine function to data from 54 air-quality monitoring sites over a 10-year period (2005-2014). The analytical results show that the date of maximum ozone concentration at 23 points in the last 10 years has been advanced by about 2.

Comparison of Tight Junction Protein-Related Gene mRNA Expression Levels between Male and Female Gastroesophageal Reflux Disease Patients.

Background/aims: Male predominance has been observed in the erosive reflux disease (ERD), but reverse finding in nonerosive reflux disease (NERD). This suggests sex-specific medicine approach is needed but its mechanism is remained to be elucidated. We aimed to compare clinical characteristics and mRNA expression levels of tight junction-related proteins between male and female gastroesophageal reflux disease (GERD).

Clinical efficacy of endoscopic ultrasonography for decision of treatment strategy of gastric cancer.

Background: Accurate preoperative tumor staging of gastric cancer is indispensable with expansion of indications for laparoscopic surgery and endoscopic resection. It is important to distinguish mucosal cancer (T1a) in smaller lesion and differentiate early gastric cancer (EGC) in larger lesion considering endoscopic resection indication and laparoscopic surgery indication. We evaluated the clinical outcomes of endoscopic ultrasonography (EUS) for the decision of treatment strategy of gastric cancer compared with pathological staging.

Continuous Use of Thienopyridine May Be as Safe as Low-Dose Aspirin in Endoscopic Resection of Gastric Tumors.

Background/aims: Current guidelines recommend withholding antiplatelets for 5-7 days before high-risk endoscopic procedures. We investigated whether this reduces post-endoscopic submucosal dissection (ESD) bleeding.

Methods: Gastric ESD cases with antiplatelets were retorospectively reviewed.

Gender differences in ghrelin, nociception genes, psychological factors and quality of life in functional dyspepsia.

Aim: to evaluate gender differences in the aspect of ghrelin, nociception-related genes and psychological aspects and the quality of life (QoL) in Korean functional dyspepsia (FD) patients.

Methods: Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital, and classified into control and FD group based on ROME III criteria. Questionnaire included assessment for dyspepsia symptoms, QoL and anxiety or depression.

Long-Term Effects of Eradication on Metachronous Gastric Cancer Development.

Background/aims: Gastric mucosal atrophy and intestinal metaplasia due to infection are the main precursor lesions of gastric cancer. The aim of this study was to evaluate the long-term effects of eradication on the progression of precancerous lesions to metachronous cancer after endoscopic resection of early gastric cancer (EGC).

Methods: Patients who underwent endoscopic resection of EGC were retrospectively reviewed.

Is Associated with Expression through Promoter Methylation in Gastric Carcinogenesis.

Background/aims: To investigate whether eradication can reverse epigenetic silencing of microRNAs (miRNAs) which are associated with -induced gastric carcinogenesis.

Methods: We examined expression and promoter methylation of , , , and in gastric cancer cell line, before/after demethylation. Among them, epigenetically controlled miRNAs were identified.

Risk factors for early metachronous tumor development after endoscopic resection for early gastric cancer.

Background: Metachronous gastric tumor (MGT) is one of major concerns after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Optimal follow-up strategy has not been yet well-established. The aim of this study was to identify the different clinical features of the patients according to the time interval to development of MGT.

Surveillance strategy according to age after endoscopic resection of early gastric cancer.

Background: Whether surveillance strategy after curative endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) differs in young patients is unclear. This study aimed to evaluate the risk of metachronous and extragastric recurrence in young patients with EGC after curative ESD.

Methods: We retrospectively enrolled 1237 consecutive patients who underwent curative ESD for EGC from 2005 to 2014 at a single tertiary hospital.

Novel risk stratification for metachronous recurrence after curative endoscopic submucosal dissection for early gastric cancer.

Background And Aims: This study stratified the risk of developing metachronous gastric cancer (MGC) after curative endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) to enable customization of endoscopic surveillance for MGC.

Methods: A total of 1115 patients who underwent curative ESD based on the expanded criteria for differentiated EGC from 2005 to 2014 at a single tertiary hospital were enrolled in this retrospective cohort study. They were followed up with annual endoscopy for a median of 50.

Comparisons of Gut Microbiota Among Healthy Control, Patients With Conventional Adenoma, Sessile Serrated Adenoma, and Colorectal Cancer.

Background: Studies on gut microbiota regarding colorectal carcinogenesis, including sessile serrated adenoma (SSA), have been scarce. The aim of this study is to investigate the role of mucosa-associated gut microbiota in the colorectal carcinogenesis.

Methods: We collected biopsy samples of normal rectal mucosa during colonoscopy from healthy control and patients with conventional adenoma, SSA, and colorectal cancer (CRC), respectively (n = 6).

Helicobacter pylori-induced modulation of the promoter methylation of Wnt antagonist genes in gastric carcinogenesis.

Background: This study aimed to investigate the changes in the promoter methylation and gene expression of multiple Wnt antagonists between the chronic infection and eradication of Helicobacter pylori (H. pylori) in gastric carcinogenesis.

Methods: The levels of methylation and corresponding mRNA expression of seven Wnt antagonist genes (SFRP1, -2, -5, DKK1, -2, -3, WIF1) were compared among the patients with H.