Selective Laser Trabeculoplasty for Medically Uncontrolled Pseudoexfoliation Glaucoma in Korean Patients.

Purpose: This study investigated the efficacy and safety of selective laser trabeculoplasty (SLT) in Korean patients with medically uncontrolled pseudoexfoliation glaucoma (PEXG).

Methods: This retrospective observational study enrolled 43 medically uncontrolled PEXG patients who underwent a 360° SLT and were followed up for at least 12 months after SLT. The intraocular pressure (IOP) before and after SLT at 1 week, 1, 3, 6, and 12 months was evaluated.

Lamina Cribrosa-Related Parameters Assessed by Optical Coherence Tomography for Prediction of Future Glaucoma Progression.

Purpose: To evaluate the value of lamina cribrosa (LC)-related parameters assessed by optical coherence tomography (OCT) in the future prediction of glaucomatous progression.

Methods: Glaucoma or glaucoma suspect eyes were followed up for more than 2 years. Glaucoma progression was defined by optic disc/retinal nerve fiber layer (RNFL) photographic assessment or serial visual field exams.

Antifibrotic effects of pirfenidone on Tenon's fibroblasts in glaucomatous eyes: comparison with mitomycin C and 5-fluorouracil.

Purpose: The purpose of this study was to evaluate the antifibrotic effects of pirfenidone (PFD) on primary cultured human Tenon's fibroblasts (HTFs) from primary open-angle glaucoma (POAG) eyes, compared to mitomicin C (MMC) and 5-fluorouracil (5-FU).

Materials And Methods: Samples of human Tenon's capsule were obtained during respective surgeries from three groups of patients: patients with cataract (CAT group), patients with POAG who underwent glaucoma filtration surgery (GFS) (POAG1 group), and patients with POAG who underwent GFS due to failed bleb of previous GFS (POAG2 group). Cell toxicity, cell migration, and the expression level of α-smooth muscle actin (α-SMA) protein were evaluated in primary cultured HTFs from the three patient groups after treatment (PFD, MMC, or 5-FU).

Effect of myopia on the progression of primary open-angle glaucoma.

Purpose: To evaluate the effect of myopia on the progression of primary open-angle glaucoma.

Methods: In this retrospective cohort study, eyes were classified into nonmyopic (NMG, >0 diopters [D]), mild to moderate (MMG, 0 to -6 D), and highly myopic glaucoma (HMG, <-6 D) groups according to the level of spherical equivalent. Glaucoma progression was determined either by optic disc/retinal nerve fiber layer (RNFL) photographs or by serial visual field (VF) data.

Comparison of clinical characteristics and progression rates of bilaterally and unilaterally progressing glaucoma.

Purpose: To compare the clinical characteristics of unilaterally progressing glaucoma (UPG) and simultaneously bilaterally progressing glaucoma (BPG) in medically treated cases.

Methods: Primary open angle glaucoma patients were classified as having UPG or BPG according to an assessment of optic disc and retinal nerve fiber layer photographs and visual field analysis. Risk factors including the presence of systemic diseases (hypertension, diabetes, cerebrovascular accident, migraine, and dyslipidema) were compared between the UPG and BPG groups.

Rates and patterns of macular and circumpapillary retinal nerve fiber layer thinning in preperimetric and perimetric glaucomatous eyes.

Purpose: To evaluate and compare the rates and patterns of macular and circumpapillary retinal nerve fiber layer (cRNFL) thickness thinning, assessed by spectral-domain optical coherence tomography (Cirrus SD-OCT), in eyes with preperimetric (PPG) and perimetric glaucoma (PG).

Methods: The present retrospective cohort study included 127 eyes of 75 patients (PPG, 87; PG, 40) with a mean follow-up of 2.53 years.

Discrepancy between optic disc and nerve fiber layer assessment and optical coherence tomography in detecting glaucomatous progression.

Purpose: To compare the outcomes of Cirrus spectral-domain optical coherence tomography (OCT) and optic disc/retinal nerve fiber layer (RNFL) photographic assessment in detecting glaucomatous progression.

Methods: Two-hundred twenty-six eyes of 130 glaucoma patients (mean follow-up: 2.5 years) with at least 5 OCT examinations were included.

Relationship between 24-hour mean ocular perfusion pressure fluctuation and rate of paracentral visual field progression in normal-tension glaucoma.

Purpose: To investigate the relationship between unstable mean ocular perfusion pressure (MOPP) and the rate of paracentral visual field (PVF) progression in patients with medically treated normal-tension glaucoma (NTG).

Methods: The data of 157 eyes of 122 patients with NTG who were followed for more than 6 years (mean follow-up, 8.7 years ± 12.

The glaucoma detection capability of spectral-domain OCT and GDx-VCC deviation maps in early glaucoma patients with localized visual field defects.

Purpose: To evaluate and compare the glaucoma detection capabilities afforded by retinal nerve fiber layer (RNFL) thickness and deviation maps obtained using Cirrus spectral domain optical coherence tomography (Cirrus OCT), and GDx employing variable corneal compensation (GDx-VCC) in glaucoma patients with early, localized visual field (VF) loss.

Methods: This prospective controlled, comparative study was performed on 42 eyes with localized VF defects, and 42 age/refractive error-matched healthy eyes. All participants were imaged by both imaging devices at the same visit.

Ocular pulse amplitude as a dynamic parameter and its relationship with 24-h intraocular pressure and blood pressure in glaucoma.

Abnormal ocular blood flow (OBF) has been suspected as one of the underlying mechanisms of glaucoma. The ocular pulse amplitude (OPA) is considered a possible surrogate parameter for ocular blood flow (OBF) measurement and has been studied in its association with glaucoma. Although there have been several studies that reported various ocular and systemic factors in association with OPA, all of these studies were based on a single measurement of these factors as well as OPA.

Detection of macular ganglion cell loss in preperimetric glaucoma patients with localized retinal nerve fibre defects by spectral-domain optical coherence tomography.

Background: To evaluate and compare the utility of ganglion cell complex with peripapillary retinal nerve fibre layer and optic nerve head measurements for detection of localized defects in patients with preperimetric glaucoma using spectral-domain optical coherence tomography.

Design: Prospective study.

Participants: Preperimetric glaucoma patients.

Increased intraocular pressure after extensive conjunctival removal: a case report.

A 50-year-old woman, who had undergone extensive removal of conjunctiva on the right eye for cosmetic purposes at a local clinic 8 months prior to presentation, was referred for uncontrolled intraocular pressure (IOP) elevation (up to 38 mmHg) despite maximal medical treatment. The superior and inferior conjunctival and episcleral vessels were severely engorged and the nasal and temporal bulbar conjunctival areas were covered with an avascular epithelium. Gonioscopic examination revealed an open angle with Schlemm's canal filled with blood to 360 degrees in the right eye.

Clinical characteristics of glaucomatous subjects treated with refractive corneal ablation surgery.

Purpose: To evaluate the clinical characteristics of newly diagnosed glaucomatous subjects who had a history of refractive corneal ablation surgery (RCAS).

Methods: Sixty-eight glaucomatous subjects who had a history of RCAS and 68 age- and visual field (VF) mean deviation-matched glaucomatous subjects with no history of RCAS were included. Intraocular pressure (IOP), central corneal thickness (CCT), VF, and retinal nerve fiber layer thickness determined by optical coherence tomography were assessed.

Detection of glaucomatous progression by spectral-domain optical coherence tomography.

Purpose: To compare the rate of change of circumpapillary retinal nerve fiber layer (cRNFL) thickness, macular volume and thickness, and optic nerve head (ONH) parameters assessed using spectral-domain optical coherence tomography (SD-OCT) between eyes with progressing and nonprogressing glaucoma.

Design: Longitudinal, observational study.

Participants: Two hundred seventy-nine eyes from 162 glaucoma patients followed for an average of 2.

Progression of retinal nerve fiber layer thinning in glaucoma assessed by cirrus optical coherence tomography-guided progression analysis.

Purpose: To evaluate the performance of Cirrus spectral domain optical coherence tomography (SD-OCT)-guided progression analysis (GPA) software to detect progression of retinal nerve fiber layer (RNFL) thinning in glaucoma patients.

Materials And Methods: This retrospective cohort study included 272 eyes of 154 glaucoma patients. Median follow-up time was 2.

Usefulness of macular thickness derived from spectral-domain optical coherence tomography in the detection of glaucoma progression.

Purpose: To assess the reproducibility of circumpapillary retinal nerve fiber layer thickness (cRNFLT) and total macular thickness (TMT) parameters using Cirrus spectral domain optical coherence tomography (SD-OCT) and to apply this information to investigate its ability to detect cases where visual field (VF) progression was noted on event-based analysis in the eyes with early glaucomatous VF loss.

Methods: Intraclass correlation coefficient (ICC), coefficient of variation (COV), and intersession test-retest variability were calculated from the control group. The sensitivity and specificity of SD-OCT for the identification of progressive VF defects were tested on progressive and stable patients.

Macular assessment using optical coherence tomography for glaucoma diagnosis.

Optical coherence tomography (OCT) is an interferometry-based imaging modality that generates high-resolution cross-sectional images of the retina. Circumpapillary retinal nerve fibre layer (cpRNFL) and optic disc assessments are the mainstay of glaucomatous structural measurements. However, because these measurements are not always available or precise, it would be useful to have another reliable indicator.

Errors in neuroretinal rim measurement by Cirrus high-definition optical coherence tomography in myopic eyes.

Background/aims: To investigate the prevalence of, and factors associated with, errors in neuroretinal rim measurement by Cirrus high-definition (HD) spectral-domain optical coherence tomography (OCT) in myopic eyes.

Methods: Neuroretinal rim thicknesses of 255 myopic eyes were measured by Cirrus HD-OCT. The prevalence of, and factors associated with, optic disc margin detection error and cup margin detection error were assessed by analysing 72 cross-sectional optic nerve head (ONH) images obtained at 5° intervals for each eye.

Optic nerve head, retinal nerve fiber layer, and macular thickness measurements in young patients with retinitis pigmentosa.

Purpose: To evaluate optic nerve head (ONH) parameters, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness by using Cirrus HD spectral-domain optical coherence tomography (OCT) in young patients with retinitis pigmentosa (RP).

Methods: ONH parameters, RNFL thickness, and macular thickness were measured and compared between 36 eyes from 36 young RP patients (RP group; mean age, 23.08 years) and 70 eyes from 70 healthy young subjects (control group; mean age, 22.

Structure-function relationship of the macular visual field sensitivity and the ganglion cell complex thickness in glaucoma.

Purpose: We attempted to understand better the relationship between the macular visual field (VF) mean sensitivity (MS) assessed by standard automated perimetry (SAP) and the ganglion cell complex thickness (GCCT), and macular peripapillary retinal nerve fiber layer thickness (mpRNFLT) assessed by spectral domain optical coherence tomography (SD-OCT, RTVue-100) in open-angle glaucoma (OAG) patients.

Methods: We enrolled in the study 217 OAG patients with baseline intraocular pressure (IOP) in the statistically normal range. GCCT and mpRNFLT measurements, using the ganglion cell complex (GCC) and the optic nerve head (ONH) modes of RTVue-100 OCT, were obtained for analysis.

Glaucoma progression in eyes with a history of refractive corneal surgery.

Purpose: To evaluate the glaucoma progression in patients with a history of refractive corneal surgery (RCS).

Methods: A total of 313 eyes of 313 glaucoma patients (RCS group, 34 eyes; non-RCS group, 279 eyes) with a mean follow-up period of 2.7 years were included.

Glaucoma progression detection by retinal nerve fiber layer measurement using scanning laser polarimetry: event and trend analysis.

Purpose: To evaluate the use of scanning laser polarimetry (SLP, GDx VCC) to measure the retinal nerve fiber layer (RNFL) thickness in order to evaluate the progression of glaucoma.

Methods: Test-retest measurement variability was determined in 47 glaucomatous eyes. One eye each from 152 glaucomatous patients with at least 4 years of follow-up was enrolled.

Factors associated with the signal strengths obtained by spectral domain optical coherence tomography.

Purpose: The aim of this study was to investigate factors associated with the signal strengths (SS, image quality scores) of optic disc and macular images obtained using Cirrus spectral domain optical coherence tomography (OCT).

Methods: Ninety-two glaucomatous eyes were imaged using the Cirrus OCT macular and optic disc cube modes after pupil dilation. The influences of patient age, spherical equivalent, cataract presence, and cataract and glaucoma severity (visual field mean deviation), on the SS of images obtained using the two cube modes were compared between patients whose images showed high SS (SS ≥7) and low SS (SS <7).

Detection of glaucoma progression by assessment of segmented macular thickness data obtained using spectral domain optical coherence tomography.

Purpose: We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements.

Methods: The study included 141 glaucomatous and 61 healthy eyes. All glaucomatous eyes were subjected to at least four spectral domain optical coherence tomography (SD-OCT) examinations (mean follow-up, 2.

Circadian (24-hour) pattern of intraocular pressure and visual field damage in eyes with normal-tension glaucoma.

Purpose: To characterize the circadian (24-hour) pattern of habitual-position intraocular pressure (IOP) and its association with visual field (VF) damage in eyes with normal-tension glaucoma (NTG).

Methods: A total of 177 eyes with NTG were examined over a 3-year period. IOP was recorded at 8 AM, 10 AM, 12 PM, 2 PM, 4 PM, 6 PM, 8 PM, 10 PM, 12 AM, 3 AM, and 6 AM by a single, well-trained ophthalmology resident using a hand-held tonometer.