Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data.

Purpose: Growth hormone (GH) treatment has been used to improve growth in short children who were born small for gestational age (SGA). The aim of this study was to investigate the long-term efficacy of GH treatment in these children.

Methods: Data from a multicenter observational clinical trial (ClinicalTrials.

Comparison of the clinical characteristics and outcomes of pediatric patients with and without diabetic ketoacidosis at the time of type 1 diabetes diagnosis.

Purpose: We investigated the possible effects of diabetic ketoacidosis (DKA) at the initial diagnosis of type 1 diabetes mellitus (T1DM) on the clinical outcomes of pediatric patients.

Methods: Medical records of children and adolescents with newly diagnosed T1DM seen in the Ajou University Hospital from January 2008 to August 2020 were reviewed and analyzed.

Results: Among 129 diagnosed T1DM patients, 40.

Long-term outcomes of Graves' disease in children and adolescents receiving antithyroid drugs.

Purpose: Antithyroid drugs (ATDs) are primarily used as an initial treatment in pediatric patients with Graves' disease (GD). We aimed to investigate the long-term outcomes in pediatric GD patients receiving ATDs.

Methods: Retrospective data from a single center were collected from April 2003 to July 2020.

Factors influencing growth hormone therapy effect during the prepubertal period in small for gestational age children without catch-up growth.

Purpose: Because small for gestational age (SGA) children who fail to experience catch-up growth have an increased risk of short stature in adulthood, growth hormone (GH) treatment is recommended for effective growth. In this study, we evaluated the effect of GH treatment during the prepubertal period and analyzed for correlation between GH treatment response and clinical factors in SGA children.

Methods: A retrospective, single-center study was conducted from 2014 to 2020.

Effectiveness of growth hormone therapy in children with Noonan syndrome.

Purpose: Recombinant human growth hormone (rhGH) has been used to improve growth in children with Noonan syndrome (NS). This study aimed to investigate the efficacy of rhGH therapy in Korean children with NS.

Methods: Seventeen prepubertal children (10 boys, 7 girls) with NS who received rhGH therapy for at least 3 years between 2008 and 2017 were included.

Low Bone Mineral Density at Initial Diagnosis in Children and Adolescents with Graves' Disease.

Previous studies have reported reduced bone mineral density (BMD) in patients with hyperthyroidism. We assessed the association of BMD in children and adolescents with Graves' disease (GD) after correcting for potential confounders affecting BMD such as age, sex, and pubertal status. Forty-four children and adolescents with GD and 172 age- and sex-matched healthy controls were enrolled in this study.

Identification of rare missense mutations in and associated with familial central precocious puberty via whole-exome sequencing.

Genetic factors play a critical role in pubertal progression; however, mutations associated with central precocious puberty (CPP) have been reported only in four genes: , , and . This study aimed to identify novel, potentially pathogenic variants in patients with familial CPP whole-exome sequencing (WES). WES analysis was applied in 28 patients (25 girls and three boys) belonging to 14 families, wherein all siblings were diagnosed with CPP.