Diagnostic and Prognostic Values of Neutrophil Reactivity Intensity (NEUT-RI) in Pediatric Systemic Inflammatory Response Syndrome and Sepsis.

Objective: Recent advances in hematology analyzers have generated cell population data (CPD), which quantify features of cells. The characteristics of CPD in pediatric systemic inflammatory response syndrome (SIRS) and sepsis were evaluated with 255 patients.

Methods: The ADVIA 2120i hematology analyzer was used for measurement of the delta neutrophil index (DN) including DNI and DNII.

Effects of Integrative Cognitive Function Improvement Program on Cognitive Function, Oral Health, and Mental Health in Older People: A Randomized Clinical Trial.

We aimed to investigate the effects of an integrative cognitive function improvement program that combined existing cognitive, emotional, and physical therapies on cognitive function, oral health, and mental health in elder participants. Participants were classified into one of the following groups: cognitively normal (CN; = 18), mild cognitive impairment (MCI; = 17), and control ( = 17). An integrative cognitive function improvement program was administered to the CN and MCI groups for six weeks.

Effectiveness of an oral health education programme using a mobile application for older adults: A randomised clinical trial.

Objective: To investigate the effectiveness of an oral health education programme using a mobile app for adults aged 65 years or older.

Methods: Participants aged 65 or older were randomly allocated into non-app use (n = 25), app use (n = 22) and control (n = 26) groups. The non-app use group received lecture-based oral health education using PowerPoint presentations and participated in workbook activities twice a week for five weeks, whereas the app use group underwent oral health education using a smartphone app and workbook activities for five weeks.

Associations between Mental Health and Oral Health among Korean Adolescents: Analysis of the National Surveys (2008-2017).

We aimed to analyze the trends and associations between the oral and mental health of Korean adolescents using the Korea Youth Risk Behavior Web-based Surveys. In total, 713,713 adolescents who participated in the surveys were included. To examine trends in oral and mental health, Pearson's correlation coefficients were calculated between the weighted percentages and years, and the regression line slope was assessed to estimate annual changes.

Diversity of Acupuncture Point Selections According to the Acupuncture Styles and Their Relations to Theoretical Elements in Traditional Asian Medicine: A Data-Mining-Based Literature Study.

Acupuncture point (AP) selections can vary depending on clinicians' acupuncture style, and therefore, acupuncture style is an important factor in determining the efficacy of acupuncture treatment. However, few studies have examined the differences in AP selections according to the acupuncture styles and theoretical backgrounds causing the differences. We compared the AP prescriptions used for 14 diseases in three classical medical textbooks, (DEBG), (SADI), and (CGGHB), which represent unique acupuncture styles and have affected clinicians during this time.

Effects of Professional Oral Health Care Programs for Elderly Residents of Nursing Facilities.

The purpose of this study was to investigate the effects of a professional oral health care program on the oral health status and salivary flow of elderly people living in nursing homes. Elderly residents aged ≥ 65 years, living in a nursing home, were randomly assigned to either a one-week interval, two-week interval, or control group, and received an oral health intervention accordingly over a period of 12 weeks. Plaque index, tongue coating, gingival index, and salivary flow rate were compared before and after the oral health intervention within and between the groups.

Effects of lingual exercises on oral muscle strength and salivary flow rate in elderly adults: a randomized clinical trial.

Aim: The present study investigated the effects of two types of lingual exercise (tongue-hold swallowing and tongue-pressure resistance training) on oral muscle strength, salivary flow rate and subjective oral health of the elderly.

Methods: We randomly assigned 74 elderly adults (≥65 years) to three groups (tongue-hold swallowing, tongue-pressure resistance training and control groups). Each group participated in 8 weeks of their appropriately prescribed intervention.

Effectiveness of an oral health education programme for older adults using a workbook.

Objective: This study investigated the effects of an oral health education programme utilising a workbook for people aged 65 years or older.

Materials And Methods: A pre-post quasi-experimental design was used to verify the effectiveness of an oral health education programme using a workbook. Oral health education was provided once a week for 5 weeks from May to June 2019.

Association between oral health status and chronic obstructive pulmonary disease in Korean adults.

Objectives: This study aimed to elucidate the association between oral health status and chronic obstructive pulmonary disease (COPD) in Korean adults (≥ 40 years old) using a representative national dataset from the 6th Korea National Health and Nutrition Examination Survey (6th KNHANES, 2013-2015).

Methods: Participants aged ≥ 40 years from the 6th KNHANES who had received an oral and pulmonary function tests (N = 7719) were included in this study. The participant characteristics according to COPD were compared using t-test and chi-squared test.

Association of oral health and activities of daily living with cognitive impairment.

Objectives: This study compared the oral health status between elderly individuals with and without cognitive impairment and explored the association of oral health and activities of daily living (ADL) with cognitive impairment.

Methods: We conducted convenience sampling on patients aged more than 65 years and analysed data from 630 participants. Data were collected and analysed via a survey evaluating general characteristics, oral health behaviour, subjective oral health status, Oral Health Impact Profile (OHIP-14), Geriatric Oral Health Assessment Index (GOHAI) and ADL.

Relationship between rheumatoid arthritis and periodontal disease in Korean adults: Data from the Sixth Korea National Health and Nutrition Examination Survey, 2013 to 2015.

Background: This study aims to investigate the relationship between rheumatoid arthritis and periodontal disease using data from the Sixth Korea National Health and Nutrition Examination Survey (KNHANES, 2013 to 2015).

Methods: Of 22,948 KNHANES participants, 14,264 who were aged ≥19 years and responded to questions pertaining to periodontal disease and rheumatoid arthritis were analyzed. Periodontal status was measured using the Community Periodontal Index.

Erratum to "Distribution of Seven N-Nitrosamines in Food" [Toxicol. Res. 31 (2015) 279-298].

[This corrects the article on p. 279 in vol. 31, PMID: 26483887.

Improved Diagnostic and Prognostic Power of Combined Delta Neutrophil Index and Mean Platelet Volume in Pediatric Sepsis.

This study aims to evaluate the diagnostic and prognostic significance of white blood cell (WBC) and platelet parameters measured by automated hematology analyzers in pediatric sepsis. The study included 232 pediatric patients whose C-reactive protein test had been requested for evaluation of infection or inflammation at a pediatric tertiary hospital. The patients were allocated to control, systemic inflammatory response syndrome (SIRS) without infection, and sepsis groups.

Efficacy of hyaluronan-rich transfer medium on implantation and pregnancy rates in fresh and frozen-thawed blastocyst transfers in Korean women with previous implantation failure.

Objective: To evaluate the effect of hyaluronan-rich transfer medium on pregnancy and implantation rates in fresh and frozen-thawed embryo transfers in Korean women with previous implantation failure.

Methods: This retrospective study included 283 blastocyst transfers in patients with previous embryo transfer failure at a private fertility clinic. In the study group (n=88), blastocyst transfers were performed using an hyaluronan-rich transfer medium prior to transfer, whereas blastocyst transfers without any treatment served as controls (n=195).

Distribution of Seven N-Nitrosamines in Food.

N-nitrosamines, which are classified as carcinogens by IARC and US EPA, can be easily found in various foods. They are reaction products between nitrogen oxide and secondary amines, but can also be generated during fermentation. Ever since the 1960s, when nitrite, used as a preservative in processed meats, was suspected to generate N-nitrosamines, the usage of the food additive has been debated.

Translational regulation of NeuroD1 expression by FMRP: involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cells.

Fragile X mental retardation protein (FMRP) is encoded by Fmr1 gene in which mutation is known to cause fragile X syndrome characterized by mental impairment and other psychiatric symptoms similar to autism spectrum disorders. FMRP plays important roles in cellular mRNA biology such as transport, stability, and translation as an RNA-binding protein. In the present study, we identified potential role of FMRP in the neural differentiation, using cortical neural progenitor cells from Sprague-Dawley rat.

Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL.

Background: At the beginning of neurogenesis, massive brain cell death occurs and more than 50% of cells are eliminated by apoptosis along with neuronal differentiation. However, few studies were conducted so far regarding the regulation of neural progenitor cells (NPCs) death during development. Because of the physiological role of cell death during development, aberration of normal apoptotic cell death is detrimental to normal organogenesis.

Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascades.

Background: Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated. The product of Fmr1, fragile X linked mental retardation protein (FMRP) is widely expressed in HeLa cells, however the roles of FMRP within HeLa cells were not elucidated, yet. Interacting with a diverse range of mRNAs related to cellular survival regulatory signals, understanding the functions of FMRP in cellular context would provide better insights into the role of this interesting protein in FXS.

Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture.

Oroxylin A (5,7-dihydroxy-6-methoxyfavone) is a flavonoid compound originated from the root of Scutellaria baicalensis Georgi. Our previous reports suggested that oroxylin A improves memory function in rat, at least in part, by its antagonistic effects on GABA(A) receptor. In addition, oroxylin A protects neurons from ischemic damage by mechanisms currently not clear.