Publications by authors named "Junfen Wei"
Programmed cell death contributes to neurological damage in ischemic stroke, especially during the reperfusion stage. Several cell death pathways have been tested preclinically and clinically, including ferroptosis, necroptosis, and apoptosis. However, the sequence and complex interplay between cell death pathways during ischemia/reperfusion remains under investigation.
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- Delirium is a serious brain condition often seen in the elderly, which can increase the risk of developing dementia later on, but its exact causes are not well understood.
- Researchers compared three mouse models of delirium created by surgical anesthesia, inflammation, and neurotransmitter modulation, discovering that certain substances affected brain activity similarly to what is seen in delirium patients.
- The study found that injecting mice with scopolamine caused temporary cognitive issues and increased activity without damaging cholinergic neurons, but it did disrupt hippocampal synapse functions, helping to shed light on how delirium might start.
Article Synopsis
- Ferroptosis affects brain cell types differently, with microglia being the most sensitive and neurons showing relative resistance.
- In mixed cultures, astrocytes, microglia, and neurons were more resistant to ferroptosis than when cultured individually.
- Understanding these differences in sensitivity can help develop strategies to prevent brain cell death in various disorders.