Polyketide production in a mangrove-associated fungus , induced by chemical epigenetic modification.

Studies on the chemical composition of endophytic fungus , isolated from the L., by using epigenetic modification to activate clusters of biosynthetic genes that are silenced or poorly expressed in fungi, resulting in obtainment of ten polyketides. Among these compounds were six new compounds, including cytosporin E2 (), cytosporin D1 (), cytosporin G1 (), cytosporin J1 (), cytosporin K1 (), cytosporin F1 (), and four known compounds, cytosporin E (), cytosporin Y3 (), cytosporin D (), and cytosporin L ().

Study protocol and preliminary baseline characteristics of a VA multi-site, mixed methods, randomized controlled study evaluating supported employment provided to veterans with opioid use disorder.

Opioid Use Disorder (OUD) is a pervasive and devastating public health crisis that continues to take a heavy toll on individuals and communities across the United States. In 2021, approximately 473,000 veterans misused opioids in the past year. In the context of their military service and post-service life, Veterans with OUD often encounter unique barriers to recovery, including the reintegration into civilian society and the pursuit of stable, meaningful employment.

Elucidating the role of 4-hydroxy-2(3H)-benzoxazolone in chronic alcoholic liver disease via transcriptomics and metabolomics.

Background: Chronic alcoholic liver disease (CALD) is a global health problem which includes multiple pathological processes such as immune inflammation and oxidative stress. 4-hydroxy-2(3H)-benzoxazolone (HBOA), an alkaloid isolated from L, has been shown to exert hepatoprotective and immunomodulatory effects. However, its effects on CALD remain unclear.

Identification of Penexanthone A as a Novel Chemosensitizer to Induce Ferroptosis by Targeting Nrf2 in Human Colorectal Cancer Cells.

Ferroptosis has emerged as a potential mechanism for enhancing the efficacy of chemotherapy in cancer treatment. By suppressing nuclear factor erythroid 2-related factor 2 (Nrf2), cancer cells may lose their ability to counteract the oxidative stress induced by chemotherapy, thereby becoming more susceptible to ferroptosis. In this study, we investigate the potential of penexanthone A (PXA), a xanthone dimer component derived from the endophytic fungus obtained from mangrove plant , to enhance the therapeutic effect of cisplatin (CDDP) on colorectal cancer (CRC) by inhibiting Nrf2.

Predicting meditation practices among individuals with cardiovascular diseases: A logistic regression analysis.

Purpose/objective: Since the prevalence and cost of cardiovascular diseases (CVD) are high in the United States, research on affordable preventative and treatment approaches is needed. While meditation shows promise for heart-health promotion, there is little knowledge about its use among people with CVD and factors that may influence its usage. In response, the purposes of the current research are to (a) shed light on the proportion of people with CVD who practice meditation; and (b) reveal variables that predict the use of meditation among them.

12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4.

Aims: The xanthone dimer 12-O-deacetyl-phomoxanthone A (12-ODPXA) was extracted from the secondary metabolites of the endophytic fungus Diaporthe goulteri. The 12-ODPXA compound exhibited anticancer properties in murine lymphoma; however, the anti-ovarian cancer (OC) mechanism has not yet been explored. Therefore, the present study evaluated whether 12-ODPXA reduces OC cell proliferation, metastasis, and invasion by downregulating pyruvate dehydrogenase kinase (PDK)4 expression.

Abnormal expression and clinical value analysis of long noncoding RNA cancer susceptibility candidate 2 in children with severe pneumonia complicated with respiratory failure.

Objective: Severe pneumonia occurs commonly in children and is the main cause of clinical infant mortality. This study tested the expression pattern of long noncoding RNA cancer susceptibility candidate 2 (CASC2) in the serum of children with severe pneumonia and explored its clinical values.

Methods: Serum levels of CASC2 were detected in 145 children with severe pneumonia.

[Mechanism of polyphyllin Ⅰ targeting EGFR to affect proliferation and apoptosis of human breast cancer cells].

This study aims to investigate the molecular mechanism of polyphyllin Ⅰ(PPⅠ) inhibiting proliferation of human breast cancer cells. Human breast cancer BT474 and MDA-MB-436 cells were treated with different concentrations of PPⅠ, and then the effect of PPⅠ on cell proliferation was detected by MTT assay, trypan blue dye exclusion assay, real-time cell analysis, and clone forming assay, respectively. The apoptosis was detected by Annexin V-FITC/PI staining and then analyzed by flow cytometry.

An Exploration of Spiritual Well-being Among Homeless People: A Hierarchical Regression Analysis.

This study explored homeless people's (N = 164) spiritual well-being (SWB) in relation to race, mental illness, physical disease, resilience, and trait mindfulness. The results of hierarchical regression analysis revealed that variables of race (p = 0.003), mental illness (p = 0.

Nursing students' trait mindfulness and psychological stress: A correlation and mediation analysis.

Background: Nursing students face a great amount of psychological stress during their nursing education. Mindfulness-based training has received increased recognition from nurse educators regarding its effect on reducing students' psychological stress. Study evidence has supported that cultivation of trait mindfulness through Mindfulness-based training was the key to this effect.

Understanding self-report Multidimensional Attitudes Scale Toward People with Disabilities: An exploratory analysis.

Purpose/objective: This study aimed to explore the factor structure of the Multidimensional Attitudes Scale Toward People With Disabilities (MAS) using participants from South Korea and assess the impact of participants' social desirability on this South Korean version of the MAS (MAS-K). Research Method/Design: One hundred eighty-nine college students without disabilities from 4 universities in South Korea completed an online survey. Among them, 75 were females.