Publications by authors named "Junekong Yong"
Article Synopsis
- Allograft fibrosis is becoming more common in pediatric liver transplant patients over time, significantly affecting long-term graft health and survival.
- A new blood test called Pediatric Liver Transplantation-Liver Fibrosis Evaluation (PT-LIFE) was developed to noninvasively detect allograft fibrosis using blood samples and other clinical data.
- The PT-LIFE assay shows high sensitivity and specificity in identifying fibrosis levels and could improve monitoring and outcomes for pediatric liver transplant recipients.
Article Synopsis
- Inherited metabolic liver diseases are genetic disorders that disrupt liver metabolism, mostly affecting children and impacting various metabolic pathways like iron and amino acids.
- Traditional research has focused on changes in liver cells, but new findings suggest these diseases also significantly impact the immune system.
- This review aims to highlight the immune-related aspects of these diseases and propose new treatment strategies, broadening the understanding of their mechanisms.
Background: Hepatoblastoma (HB) is the most common pediatric liver tumor, presenting significant therapeutic challenges due to its high rates of recurrence and metastasis. While Inosine Monophosphate Dehydrogenase 2(IMPDH2) has been associated with cancer progression, its specific role and clinical implications in HB have not been fully elucidated.
Methods: This study utilized Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and Tissue Microarray (TMA) for validation.
Background: The high recurrent rate after liver transplantation (LT) remains a clinical challenge, especially for those exceeding the Milan criteria (MC) and with high RETREAT scores. Therefore, the authors aim to investigate whether neoadjuvant systemic therapy allows safely administered and effectively reduces post-LT recurrence for those patients.
Methods: In this prospective, randomized, open-label, pilot study, patients with HCC exceeding the MC were randomly assigned to PLENTY or control group before LT.
Article Synopsis
- The study investigates the association between intra-patient variability (IPV) of tacrolimus (TAC) levels and patient outcomes in pediatric liver transplant (PLT) recipients, as high IPV is linked to poor results post-transplant in adults but needs confirmation in children.
- A total of 848 PLT recipients were analyzed; patients with high IPV (≥45% coefficient of variation of TAC levels) had a longer hospital stay and significantly worse 1-year graft and recipient survival rates compared to those with low IPV (<45%).
- The findings suggest that monitoring TAC variability can be an important strategy for improving outcomes in pediatric liver transplantation, highlighting high IPV as an independent risk factor for increased mortality.
Surgical residual tumor lesions (R1 resection of surgical procedures (e.g., liver cancer infiltrating the diaphragm, surgical residual breast cancer, postoperative residual ovarian cancer) or boundary residual after ablation) and lymph node metastasis that cannot be surgically resected (retroperitoneal lymph nodes) significantly affect postoperative survival of tumor patients.
View Article and Find Full Text PDFPost-transplant lymphoproliferative disorder (PTLD) is one of the most serious complications after transplantation. Epstein-Barr virus (EBV) is a key pathogenic driver of PTLD. About 80% of PTLD patients are EBV positive.
View Article and Find Full Text PDFPurpose: The indocyanine green retention rate at 15 min (ICG-R15) is of great importance in the accurate assessment of hepatic functional reserve for safe hepatic resection. To assist clinicians to evaluate hepatic functional reserve in medical institutions that lack expensive equipment, we aimed to explore a novel approach to predict ICG-R15 based on CT images and clinical data in patients with hepatocellular carcinoma (HCC).
Methods: In this retrospective study, 350 eligible patients were enrolled and randomly assigned to the training cohort (245 patients) and test cohort (105 patients).