Publications by authors named "June Po"
Article Synopsis
- - This study investigates the relationship between mental health diagnoses (like major depressive episodes, dysthymic disorder, and manic episodes) and their associated symptoms using simulated data rather than real-world cases.
- - Researchers generated random populations with varying symptom prevalence and correlations to analyze the significance of these associations, using data from the DSM-IV-TR for reference.
- - Findings revealed that the diagnoses did not consistently correlate with their own symptoms across all simulations, notably under certain conditions, while some symptoms showed significant correlations, especially when there was overlap between major depressive episodes and dysthymic disorder.
Background Relative measures, including risk ratios (RRs) and odds ratios (ORs), are reported in many epidemiological studies. RRs represent how many times a condition is likely to develop when exposed to a risk factor. The upper limit of RRs is the multiplicative inverse of the baseline incidence.
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- Frailty is linked to serious health issues, but its relationship with frailty symptoms isn't well understood, driving this study's examination of their associations.
- Researchers used data from the Health and Retirement Study to analyze three common frailty diagnosis models, revealing weak correlations between frailty statuses and symptoms, with 49 symptoms identified.
- The study found that frailty diagnoses did not significantly correlate with many symptoms from their own models or others, raising questions about the validity of these symptoms in diagnosing frailty and the overall understanding of frailty itself.
Background: The dimensions along which mortality is patterned in India remains unclear. We examined the specific contribution of social castes, household income, assets, and monthly per capita consumption to mortality differentials in India.
Methods And Findings: Cross-sectional data on 217,363 individuals from 41,554 households from the 2004-2005 India Human Development Survey was analyzed using multiple logistic regressions.
Background: Numerous studies with varying associations between domestic use of solid biomass fuels (wood, dung, crop residue, charcoal) and respiratory diseases have been reported.
Objective: To present the current data systematically associating use of biomass fuels with respiratory outcomes in rural women and children.
Methods: Systematic searches were conducted in 13 electronic databases.
In eukaryotes, proteins containing RNA Recognition Motifs (RRMs) are involved in many different RNA processing reactions, RNA transport, and mRNA decay. Kinetoplastids rely extensively on post-transcriptional mechanisms to control gene expression, so RRM domain proteins are expected to play a prominent role. We here describe the results of an RNA interference screen targeting 37 of the 72 RRM-domain proteins of Trypanosoma brucei.
View Article and Find Full Text PDFControl of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both the exosome and a 5'-3'-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation, and it revealed roles for proteins with RNA recognition motifs or pumilio domains.
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