Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.

This study aims to investigate whether butylphthalide can inhibit ferroptosis and ameliorate cerebral ischaemia-reperfusion (I/R) injury in rats by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) / heme oxygenase-1 (HO-1) signalling pathway, known for its antioxidative and cytoprotective properties. Middle cerebral artery occlusion reperfusion (MCAO/R) rat models were established. Male rats were randomly divided into five groups: a sham-operated group (sham), MCAO/R group, MCAO/R ​+ ​ML385 (Nrf2-specific inhibitor) group, MCAO/R ​+ ​NBP (butylphthalide) group and MCAO/R ​+ ​ML385 ​+ ​NBP group.

Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway.

Objective: To investigate whether pentoxifylline (PTX) attenuates cerebral ischaemia-reperfusion injury (IRI) in rats by inhibiting ferroptosis and to explore the underlying molecular mechanisms.

Methods: Cerebral IRI was induced in male Sprague-Dawley (SD) rats using middle cerebral artery occlusion (MCAO). The effects of PTX on cerebral ischaemia-reperfusion brain samples were detected through neurological deficit score, staining and electron microscopy; levels of ferroptosis biomarkers from brain samples were detected using kits.

Butylphthalide protects against ischemia-reperfusion injury in rats via reducing neuron ferroptosis and oxidative stress.

Local ischemia in the cerebra leads to vascular injury and necrosis. Ferroptosis is involved in the pathophysiological process of many diseases and widely exists when ischemia-reperfusion injury occurs in many organs. The aim of this study was to evaluate the effect of Butylphthalide (NBP) on middle cerebral artery occlusion (MCAO) rats model-caused neuron injury.

Generation of Leydig-like cells: approaches, characterization, and challenges.

Testosterone production by Leydig cells (LCs) plays a crucial role in male reproduction. The functional degeneration of LCs can cause testosterone deficiency, ultimately resulting in primary male hypogonadism. Transplantation of exogenous LCs with the ability to produce testosterone in response to the regulation of the hypothalamus-pituitary-gonad axis could be a promising alternative option to treat male primary hypogonadism.

Stress Corrosion Cracking Behavior of TP 439 and 690 TT under Film-Forming Amine Environment.

Film-forming amines have been widely used in thermal power plants for maintenance after shutdown, and there are more and more applications and researches in nuclear power secondary circuits for this purpose. However, in the direction of stress corrosion cracking, there is not much research on the influence of film-forming amines on metal materials. This article uses the high temperature slow strain rate test (SSRT) method to evaluate the influence of a commercial film-forming amine on the stress corrosion cracking behavior of two conventional island materials for PWR nuclear power plants.

Removal of endocrine disrupting chemicals from aqueous phase using spherical microporous carbon prepared from waste polymeric exchanger.

A spherical microporous carbon adsorbent (CR-1), which was developed by carbonization and activation of the waste polysulfonated cation-exchanger, was used to remove Dimethyl phthalate (DMP) and 2, 4-dichlorophenol (2, 4-DCP) as the model compounds of EDCs from the aqueous solution. Four adsorption isotherm models, Langmuir, Freundlich, Toth and Polanyi-Dubinin-Manes equations were tested to correlate the experimental data, Toth and Polanyi-Dubinin-Manes isotherms models provided the best correlation. The Henry's law constants calculated from Toth equation were found to be 705.

Adsorption of naphthalene onto the carbon adsorbent from waste ion exchange resin: equilibrium and kinetic characteristics.

Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants that can result in serious health problems and genetic defects in humans. In this research, a spherical microporous carbon adsorbent (CR-1) had been obtained by carbonization and activation of the waste polysulfonated cation exchange resin. Naphthalene was adopted as a model compound to examine the adsorption effectiveness for removing PAHs from the aqueous solution by CR-1.

[Cooperative adsorption of 1-naphthol and 1-naphthylamine onto hyper-crosslinked polymeric adsorbents].

Cooperative simultaneous adsorptions of 1-naphthol and 1-naphthylamine from aqueous solutions on hyper-cross-linked polymeric adsorbents (NDA103 and NDA100) were investigated. The results indicate that at the higher equilibrium concentrations, the total uptake amounts of 1-naphthol and 1-naphthylamine in binary systems (1-naphthol: 1-naphthylamine = 3:1, 1:1, 1:3) are obvious larger than the pure uptake amounts in single systems, and a large excess was noted on the particle surface at saturation, which is presumably due to the cooperative effect primarily arisen from the hydrogen bonding or weak acid-base interaction between 1-naphthol and 1-naphthylamine. The adsorption isotherms for them in both single and binary systems can be well fitted by Langmuir equation.