Publications by authors named "Junde Zhu"
Article Synopsis
- Spinal cord injury (SCI) presents global treatment challenges, and repetitive trans-spinal magnetic stimulation (rTSMS) is a promising therapy, though its exact recovery mechanisms are not well understood.
- In a study using 8-week-old female mice with SCI models, researchers compared the effects of rTSMS, LY364947 (a drug), and a combination of both on functional recovery and tissue modulation.
- Results indicated that both treatments improved recovery, reduced scar formation and inflammation, and suggested that rTSMS works by inhibiting the TGFβ1/Smad2/3 signaling pathway, highlighting its potential as a clinical treatment strategy.
Purpose: To investigate the effect of neural stem cell-derived exosomes (NSC-Exos) on neural function after rat cerebral ischemia-reperfusion injury by regulating microglia-mediated inflammatory response.
Methods: SD rats were randomly divided into Sham group, IRI group, PBS group and NSC-Exos group. Each group was divided into 1d, 3d, 7d and 14d subgroups.
Esophageal squamous cell carcinoma (ESCC) is a common malignant gastrointestinal tumor threatening global human health. For patients diagnosed with ESCC, determining the prognosis is a huge challenge. Due to their important role in tumor progression, long non-coding RNAs (lncRNAs) may be putative molecular candidates in the survival prediction of ESCC patients.
View Article and Find Full Text PDFAs an inhibitor of the Notch signaling pathway, N-[N-(3,5-difluorohenacetyl)-l-alanyl]-S-phenylglycine tert-butyl ester (DAPT) may protect brain tissue from serious ischemic injury. This study aimed to explore neuroprotection by DAPT after cerebral ischemia/reperfusion (I/R) injury. DAPT was intraperitoneally injected 3 hours before the establishment of a focal cerebral I/R model in the right middle cerebral artery of obstructed mice.
View Article and Find Full Text PDFPanax ginseng is a slow-growing perennial plant. Panax ginseng extract has numerous biological activities, including antitumor, anti-inflammatory and antistress activities. Panax ginseng extract also has a cognition-enhancing effect in rats with alcohol-induced memory impairment.
View Article and Find Full Text PDFObjective: To investigate neuroprotection of noggin-transfected neural stem cells (NSCs) against focal cerebral ischemia reperfusion injury (IRI) in rats.
Methods: Eighty Wistar rats were randomly divided into the sham, IRI, NSCs, and noggin + NSCs groups. Noggin containing adenoviral vectors was transfected into rat NSCs.
Article Synopsis
- - High levels of arsenic in drinking water have been identified as a global health issue, known to disrupt spatial memory in animals, particularly in mice exposed to varying doses of arsenic over a 12-week period.
- - The study found that arsenic at higher doses (3 mg/kg and 10 mg/kg) negatively impacted long-term memory (LTM) related to object recognition and also resulted in decreased body weight and increased arsenic levels in the brain.
- - Swimming exercise was shown to mitigate the memory impairment caused by moderate arsenic exposure (3 mg/kg) by preventing decreases in brain-derived neurotrophic factor (BDNF) and phosphorylated CREB in critical brain regions, suggesting a protective mechanism against arsenic